ID A0A2I3LH34_PAPAN Unreviewed; 1003 AA.
AC A0A2I3LH34;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Sorting nexin 25 {ECO:0000313|Ensembl:ENSPANP00000022728.2};
GN Name=SNX25 {ECO:0000313|Ensembl:ENSPANP00000022728.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000022728.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000022728.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000022728.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_003899467.2; XM_003899418.3.
DR AlphaFoldDB; A0A2I3LH34; -.
DR Ensembl; ENSPANT00000052445.2; ENSPANP00000022728.2; ENSPANG00000006290.3.
DR GeneID; 100999317; -.
DR KEGG; panu:100999317; -.
DR CTD; 83891; -.
DR GeneTree; ENSGT00950000182856; -.
DR OMA; LYALMGE; -.
DR Proteomes; UP000028761; Chromosome 3.
DR Bgee; ENSPANG00000006290; Expressed in pigmented layer of retina and 64 other cell types or tissues.
DR ExpressionAtlas; A0A2I3LH34; baseline.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06878; PX_SNX25; 1.
DR CDD; cd08720; RGS_SNX25; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037899; SNX25_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..327
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 450..564
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 671..791
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 114320 MW; 97CF46999F63E1AE CRC64;
MHPDATDSGG AGLSPARAAG AGGRPAPGFR DERRPESPGD AEAAAAVPGG PGGRSWWGPV
AVAALAAVAL SFLGPGGGEA AGAVGLSSVL LRLSLYLSCA AAAFLLGTLF ALVCRSPRAP
PPDFAAAWSR LAATSAARRP PWSPVYGNWH ESAQSRRVVI SHNMDKALKE VFDYSYRDYI
LSWYGNLSRD EGQLYHLLLE DFWEIARQLH HRLSHVDVVK VVCNDVVRTL LTHFCDLKAA
NARHEEQPRP FVLHACLRNS DDEVRFLQTC SRVLVFCLLP SKDVQSLSLR IMLAEILTTK
VLKPVVELLS NPDYINQMLL AQLEYREQVN EHHKRAYTYA PSYEDFIKLI NSNSDVEFLK
QLRYQIVVEI IQATTISSFP QLKRHKGKET AAMKADLLRA RNMKRYINQL TVAKKQCEKR
IRILGGPAYD QQEDGALEEG EGPQSQKILQ FEDILANTFY REHFGMYMER MDKRALISFW
ESVEHLKNAN KNEIPQLVGE IYQNFFVESK EISVEKSLYK EIQQCLVGNK GIEVFYKIQG
DVYEILKDRY YPSFIVSDLY EKLLIKEEEK HASQMISNKD ETGPRDEAGE EAADDSTNRI
NEQASFAVNK LRELNEKLEY KRQALNSIQN APKPDKKIVS KLRDEIILIE KERTDLQLHM
ARTDWWCENL GMWKASITSG EVTEENGEQL PCYFVTVSLQ EVGGVETKNW TVPRRLSEFQ
NLHRKLSECV PSLKKVQLPS LSKLPFKSID QKFMEKSKNQ LNKFLQNLLS DERLCQSEAL
YAFLSPSPDY LKVIDVQGKK NSFSLSSFLE RLPRDFFSHQ EEETEEDSDL SDYGDDVDGR
KDALAEPCFM LIGEIFELRG MFKWVRRTLI ALVQVTFGRT INKQIRDTVN WIFSEQMLVY
YINIFRDAFW PHGKLAPPTT IRSEEQSQET KQRAQQKLLE NIPDTLQSLV GQQNARHGII
KIFNALQEAR ANKHLLYVLM ELLLIELCPE LRTHLDQFKA GQV
//
