GenomeNet

Database: UniProt
Entry: A0A2I3LI76_PAPAN
LinkDB: A0A2I3LI76_PAPAN
Original site: A0A2I3LI76_PAPAN 
ID   A0A2I3LI76_PAPAN        Unreviewed;       878 AA.
AC   A0A2I3LI76;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPANP00000023136};
GN   Name=VAV2 {ECO:0000313|Ensembl:ENSPANP00000023136};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000023136, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000023136, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000023136}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; AHZZ02007948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02007949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02007950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02007951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02007952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02007953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003911175.1; XM_003911126.3.
DR   Ensembl; ENSPANT00000041661; ENSPANP00000023136; ENSPANG00000026098.
DR   GeneID; 101015074; -.
DR   CTD; 7410; -.
DR   GeneTree; ENSGT00940000159718; -.
DR   OrthoDB; 710582at2759; -.
DR   Proteomes; UP000028761; Chromosome 15.
DR   ExpressionAtlas; A0A2I3LI76; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR   GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
DR   GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR   GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd00014; CH; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10406; SH2_Vav2; 1.
DR   CDD; cd11980; SH3_VAV2_1; 1.
DR   CDD; cd11977; SH3_VAV2_2; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035880; VAV2_SH2.
DR   InterPro; IPR035733; VAV2_SH3_1.
DR   InterPro; IPR035732; VAV2_SH3_2.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07653; SH3_2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    120       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      198    376       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      405    512       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      523    572       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      586    652       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      673    767       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      816    877       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      290    310       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   878 AA;  101329 MW;  D6C7B6EEB5E89070 CRC64;
     MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI
     NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI
     AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV
     QQPMIRYMQK MSMTEDDKRN CCLLEIQETE AKYYHTLEDI EKNYMSPLRL VLSPADMAAV
     FINLEDLIKV HHSFLRAIDV SMMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL
     LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK
     EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH
     TKQDRYLFLF DKVVIVCKRK GYNYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY
     LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC
     KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN
     PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR
     PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI
     KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR
     SPASCASYNF SFLGPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG
     DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ
//
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