ID A0A2I3LK83_PAPAN Unreviewed; 1140 AA.
AC A0A2I3LK83;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Glutamate receptor interacting protein 2 {ECO:0000313|Ensembl:ENSPANP00000023857.2};
GN Name=GRIP2 {ECO:0000313|Ensembl:ENSPANP00000023857.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000023857.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000023857.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000023857.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2I3LK83; -.
DR STRING; 9555.ENSPANP00000023857; -.
DR Ensembl; ENSPANT00000048000.2; ENSPANP00000023857.2; ENSPANG00000010990.3.
DR GeneTree; ENSGT00940000155615; -.
DR OMA; QLYPGYE; -.
DR Proteomes; UP000028761; Chromosome 2.
DR Bgee; ENSPANG00000010990; Expressed in ventromedial nucleus of hypothalamus and 32 other cell types or tissues.
DR ExpressionAtlas; A0A2I3LK83; baseline.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0098887; P:neurotransmitter receptor transport, endosome to postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0099003; P:vesicle-mediated transport in synapse; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 7.
DR Gene3D; 2.30.42.10; -; 7.
DR InterPro; IPR043545; GRIP1/2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46227:SF4; GLUTAMATE RECEPTOR-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR46227; GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 7.
DR SUPFAM; SSF50156; PDZ domain-like; 7.
DR PROSITE; PS50106; PDZ; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 145..228
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 245..331
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 345..429
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 553..628
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 654..738
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 753..835
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1039..1121
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 60..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..953
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 122586 MW; A3EE5BE94FA40927 CRC64;
TCLSSLNEEA IDGGNGGEWG EGLLEQFTCT PSCLVEAKTA PKWPLCPGEG QGLHGKPLSD
HCQGTGDHID PSLGREGRAE QRGSRGSWWA AGETIANMLC GLSRETPGEA DDGPYSKGGK
DAGGADVSLA CRRQSIPEEF RGITVVELIK KEGSTLGLTI SGGTDKDGKP RVSNLRPGGL
AARSDLLNVG DYIRSVNGIH LTRLRHDEII TLLKNVGERV VLEVEYELPP PAPENNPRII
SKTVDVSLYK EGNSFGFVLR GGAHEDGHKS RPLVLTYVRP GGPADREGSL KVGDRLLSVD
GIPLHGASHA TALATLRQCS HEALFQVEYD VATPDTVANA SGPLIVEIVK TPGSALGISL
TTTSLRNKSV ITIDRIKPAS VVDRSGALHP GDHILSIDGT STEHCSLLEA TKLLASVSEK
VRLEILPVPQ SQRPLRPSEA VKVQRSEQLH RWDPCVPSCH SPRPGHCRMP TWATPAGQDQ
SRSLSSTPFS SPTLNHAFSC NNPSTLPRGS QPMSPRTTMG RRRQRRREHK SSLSLASSTV
GPGGQIVHTE TTEVVLCGDP LSGFGLQLQG GIFATETLSS PPLVCFIEPD SPAERCGLLQ
IGDRVLSING IATEDGTMEE ANQLLRDAAL AHKVVLEVEF DVAESVIPSS GTFHVKLPKK
HGVELGIVIS SASRKRGEPL IISDIKKGSV AHRTGTLEPG DKLLAIDNIR LDNCPMEDAV
QILRQCEDLV KLKIRKDEDN SDELETTGAV SYTVELKRYG GPLGITISGT EEPFDPIVIS
GLTKRGLAER TGAIHVGDRI LAINSVSLKG RPLSEAIHLL QVAGETVTLK IKKQLDRPLL
PRKSGSLSET SDADEDPAEA LKGGLPTARF SPAVPSVDSA VESWDSSATE GGFGGPGSYT
PQAAARGVTP QEWRPGRLRS SPPTTEPRRT SYTPTPADES FPEEEEEEED WEPPTSPAPG
PAREEGFWRV FGEALEDLES CGQSELLREL EASIMTGTVQ RAALEGRPGH RPWQRGREVR
ASPAEMEELL LPTPLEMHKV TLHKDPMRND FGFSVSDGLL EKGVYVHTVR PDGPAHRGGL
RPFDRVLQVN HVRTRDFDCC LAVPLLAEAG DVLELVISRN PLAHSSRAPR APGPSSPRML
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