ID A0A2I3LKA4_PAPAN Unreviewed; 1089 AA.
AC A0A2I3LKA4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000256|ARBA:ARBA00044203};
DE AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000256|ARBA:ARBA00044293};
GN Name=NOD2 {ECO:0000313|Ensembl:ENSPANP00000023860.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000023860.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000023860.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000023860.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A2I3LKA4; -.
DR Ensembl; ENSPANT00000042467.2; ENSPANP00000023860.2; ENSPANG00000019150.3.
DR GeneTree; ENSGT00940000160934; -.
DR Proteomes; UP000028761; Chromosome 18.
DR Bgee; ENSPANG00000019150; Expressed in zone of skin and 34 other cell types or tissues.
DR ExpressionAtlas; A0A2I3LKA4; baseline.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08788; CARD_NOD2_2_CARD15; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF64; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00619; CARD; 2.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 2.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 103..186
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 211..295
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 370..506
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1089 AA; 120718 MW; 6074C1FBE24E80E6 CRC64;
MVSRMHKALC QNCLELPSSG RLVGQLWPLA FPLGISLEGG VGRQIQAHQF CATGLLVFCT
RPTHRCHACS PSLMGFDGGR GGGPVSPDEE ERASVLLGHF LGCEMCSQEA FQAQRSQLVE
LLVSGSLEGF ESVLDWLLSW EVLSWEDYEG IHLLGQPLSH LARRLLDTVW NKGTWACQKL
VAAAQEAQAD SQSPKLHGCW DPHSLHPARD LQSHRPAIVR RLHSHVEGVL DLARERGFVS
QYECDEIRLP IFTPSQRARR LLDLATVKAN GLAAFLLQHV QELPVPLALP LEAATCRKYM
AKLRTTVSAQ ARFLSTYDGA ETLCLEDIYT ENGLEVWADA GMAGPPQKSP ATLGLEELFS
TRSHLNDDAD TVLVVGEAGS GKSTLLQRLH LLWAAGRDFQ EFLFVFPFSC RQLQCVAKPL
SVRTLLFEHC CWPDVDQEDI FQFLLDHPDR VLLTFDGFDE FKFRFTDHER HCSPTDPTSV
QTLLFNLLQG NLLKNARKVV TSRPAAVSAF LRKYIRTEFY LKGFSEQGIE LYLRKRHREP
GVADRLIRLL QATSALHGLC HLPVFSWMVS KCHQELLLQE GVSPKTTTDM YLLILQHFLL
HATSPDSASQ GLGPSLLRGR LPTLLHLGRL ALWGLGMCCY VFSAQQLQAA QVSPDDISLG
FLVRAKGVMP GSTAPLEFLH ITFQCFFAAF YLAFSADVSP ALLRHLFNCG RPGNSPMARL
LPTLCIQGSE GKDGSVAALL QKAEPHNLQI TAAFLAGLLS REHWDLLAEC QASEKALLRR
QACARWCLAR SLRKHFHSIP PAAPGEAKSM HAMPGFIWLI RSLYEMQEER LARKAARGLN
VGHLKLTFCS VGPAECAALA FVLRHLRQPV ALQLDYNSVG DIGVEQLLPC LGVCKALYLR
DNNISDRGIC KLIECALHCE QLQKLALFNN KLTDGCAHSM AKLLACRQNF LALRLGNNHI
TAAGARVLAE GLRGNASLQF LGFWGNRVGD EGAQALAEAL GDHQSLRWLS LEENHLQDEG
VCCLAEGLKR NSSLKILKLS NNCITYLGAE ALLQALEKND TILEVWLRGN IFSLEEADKL
GCRDTRLLL
//
