GenomeNet

Database: UniProt
Entry: A0A2I3LVM7_PAPAN
LinkDB: A0A2I3LVM7_PAPAN
Original site: A0A2I3LVM7_PAPAN 
ID   A0A2I3LVM7_PAPAN        Unreviewed;      4921 AA.
AC   A0A2I3LVM7;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPANP00000027519};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPANP00000027519};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000027519, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000027519, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000027519}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02017986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02017987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000037471; ENSPANP00000027519; ENSPANG00000024680.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000028761; Chromosome 1.
DR   ExpressionAtlas; A0A2I3LVM7; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4243   4262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4463   4483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4537   4556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4664   4685       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4722   4743       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4798   4821       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       91    146       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      153    198       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      206    261       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      267    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      332    389       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    790       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1006   1203       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1318   1543       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3986   4021       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      453    473       {ECO:0000256|SAM:Coils}.
FT   COILED     3037   3057       {ECO:0000256|SAM:Coils}.
FT   COILED     3304   3324       {ECO:0000256|SAM:Coils}.
FT   COILED     4375   4408       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4921 AA;  558857 MW;  1467702C77716B4F CRC64;
     EAEAGESLED DEVVLQCTAT IHKEQQKLCL AAEGFGNRLC FLESTSNSKN VPPDLSICTF
     VLEQSLSVRA LQEMLANTVE KSEGTAQGGG HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS
     TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE RYLHLSYGNG
     SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEEQRRT
     VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKNLLLMDK
     EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS VCYIQHVDTG LWLTYQSVDV
     KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK
     AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL
     ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI
     SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS LLDKHGRNHK VLDVLCSLCV
     CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI FLGVSEGSAQ YKKWYYELMV
     DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG DDLFSYGFDG LHLWSGCIAR
     TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK
     VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE YKQERTYTRD LLGPTVSLTQ
     AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV
     EFSKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED KVKKMKLPKN YQLTSGYKPA
     PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG IQQDVKNRRN PRLVPYTLLD
     DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS GTGERFRIFR AEKTYAVKAG
     RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG FKAQRWHQGN EHYGRSWQAG
     DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK
     DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL QVPSNHEHIE VTRIDGTIDS
     SPCLKVTQKS FGSQNSHTDI MFYRLSMPIE CAEVFSKTVA GGLPGAGLFG PKNDLEDYDA
     DSDFEVLMKT AHGHLVPDRV DKDKEATKPE FNNHKDYAQE KPSRLKQRFL LRRTKPDYST
     SHSARLTEDV LADDRDDYDF LMQTSTYYYS VRIFPGQEPA NVWVGWITSD FHQYDTGFDL
     DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGESMSPGQG RNNNGLEIGC VVDAASGLLT
     FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR IKNVMPLSAG LFKSEHKNPV
     PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV QCLDPLQFMS LHIPEENRSV
     DILELTEQEE LLKFHYHTLR LYSAVCALGN HRVAHALCSH VDEPQLLYAI ENKYMPGLLR
     AGYYDLLIDI HLSSYATARL MMNNEYIVPM TEETKSITLF PDENKKHGLP GIGLSTSLRP
     RMQFSSPSFV SVSNECYQYS PEFPLDILKA KTIQMLTEAV KEGSLHARDP VGGTTEFLFV
     PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAATPEE ESDTLEKELS VDDAKLQGAG
     EEEAKGGKRP KEGLLQMKLP EPVKLQMCLL LQYLCDCQVR HRIEAIVAFS DDFVAKLQDN
     QRFRYNEVMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF KDDKSECPCP EEIRDQLLDF
     HEDLMTHCGI ELDEDGSLDG NSDLTIRGRL LSLVEKVTYL KKKQAEKPVE SDSKKSSTLQ
     QLISETMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGLV RALPKTYTIN GVSVEDTINL
     LASLGQIRSL LSVRMGKEEE KLMIRGLGDI MNNKVFYQHP NLMRALGMHE TVMEVMVNVL
     GGGESKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS YLLENSSVGL ASPAMRGSTP
     LDVAAASVMD NNELALALRE PDLEKVVRYL AGCGLQSCQL LVSKGYPDIG WNPVEGERYL
     DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG GNGLLAAMEE AIKIAEDPSR
     DGPSPNSGSS KTLDTEEEED DTIHMGNAIM TFYAALIDLL GRCAPEMHLI HAGKGEAIRI
     RSILRSLIPL GDLVGVISIA FQMPTIAKDG NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE
     VQDFLLHLLE VGFLPDLRAA ASLDTVALSA TDMALALNRY LCTAVLPLLT RCAPLFAGTE
     HHASLIDSLL HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ LRPSMMQHLL RRLVFDVPLL
     NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH LSRKLFWGIF DALSQKKYEQ
     ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG NFNPQPVDTS NITIPEKLEY
     FINKYAEHSH DKWSMDKLAN GWIYGEIYSD SSKVQPLMKP YKLLSEKEKE IYRWPIKESL
     KTMLAWGWRI ERTREGDSMA LYNRTRRISQ TSQVSVDAAH GYSPRAIDMS NVTLSRDLHA
     MAEMMAENYH NIWAKKKKME LESKGGGNHP LLVPYDTLTA KEKAKDREKA QDILKFLQIN
     GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY ILEFDGGSRG KGEHFPYEQE
     IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK EKEMNIEKFS GQFIRHFVSS
     SGNDATSIVN CLHILGQTLD ARTVMKTGLE SVKSALRAFL DNAAEDLEKT MENLKQGQFT
     HTRNQPKGVT QIINYTTVAL LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG
     TSKSIYVERR RSQLKACQIL LSFEVQNAIV ACGNLPYHLS TFFEYNPFFM CTSPALSLPT
     NVEDVCPNIP SLEKLMEEIV ELAESGIRYT QMPHVMEVIL PMLCSYMSRW WEHGPENNPE
     RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL AVFSQPIINK VKPQLLKTHF
     LPLMEKLKKK AAMVVSEEDH LKAEARGDMS EAELLILDEF TTLARDLYAF YPLLIRFVDY
     NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF VVQNEINNMS FLITDTKSKM
     SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI ALAKNRFSLK
     DTEDEVRDII RSNIHLQGKL EDPAIRWQMA LYKDLPNRTD DTSDPEKTVE RVLDIANVLF
     HLEQVRLCVN SVIFALVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRAVNL
     FLQGYEKSWI ETEEHYFEDK LIEDLAKPGA DPPEEDEGTK RVDPLHQLIL LFSRTALTEK
     CCHDEEDDDG EEEVKSFEEK EMEKQKLLYQ QARLHDRGAA EMVLQTISAS KGETGPMVAA
     TLKLGIAILN GGNSTVQQKM LDYLKEKKDV GFFQSLAGLM QSCSVLDLNA FERQNKAEGL
     GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT VNIIISTVDY
     LLRVQESISD FYWYYSGKDV IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH
     SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL LKELMDLQKD MVVMLLSMLE GNVVNGTIGK
     QMVDMLVESS NNVEMILKFF DMFLKLKDLT SSDTFKEYDP DGKGVISKRD FHKAMESHKH
     YTQSETEFLL SCAETDENET LDYEEFVKRF HEPAKDIGFN VAVLLTNLSE HMPNDTRLQT
     FLELAESVLN YFQPFLGRIE IMGSAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV
     NEGGEKEKME LFVNFCEDTI FEMQLAAQIS ESDLNERSAN KEDSEKERPE EQGPRMAFFS
     ILTVKSALFA LRYNILTLMR MLSLKSLKKQ MKKVKKMTVK DMVTAFFSSY WSIFMTLLHF
     VASVFRGFFR IICSLLLGGS LVEGAKKIKV AELLANMPDP TQDEVRGDGE EGERKTLEAA
     LPSEDLTDLK ELTEESDLLS DIFGLDLKRE GGQYKLIPHN PNAGLSDLMS NPVPMPEVQE
     KFQEQKAKEE EKEEKEETKS EPEKAEGEDG EKEEKAKEDK GKQKLRQLHT HRYGEPEVPE
     SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL FVAFAINFIL LFYKVSTSSV VEGKELPTRS
     SSENAKVTSL DSGSHRIIAV HYVLEESSGY MEPTLRILAI LHTVISFFCI IGYYCLKVPL
     VIFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLPTKC FFSYPKVMDK YGEFYGRDRI
     SELLGMDKAA LDFSDAREKK KPKKDSSLSA VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM
     TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF
     NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF
     DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET KCFICGIGND YFDTVPHGFE
     THTLQEHNLA NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL
     N
//
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