ID A0A2I3LXY7_PAPAN Unreviewed; 1415 AA.
AC A0A2I3LXY7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Peroxidasin {ECO:0000313|Ensembl:ENSPANP00000028326.2};
GN Name=PXDN {ECO:0000313|Ensembl:ENSPANP00000028326.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000028326.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000028326.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000028326.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9555.ENSPANP00000028326; -.
DR Ensembl; ENSPANT00000034426.2; ENSPANP00000028326.2; ENSPANG00000011093.3.
DR GeneTree; ENSGT00940000157666; -.
DR OrthoDB; 4560at2759; -.
DR Proteomes; UP000028761; Chromosome 14.
DR Bgee; ENSPANG00000011093; Expressed in aorta and 42 other cell types or tissues.
DR ExpressionAtlas; A0A2I3LXY7; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0140825; F:lactoperoxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd05745; Ig3_Peroxidasin; 1.
DR CDD; cd05746; Ig4_Peroxidasin; 1.
DR CDD; cd09826; peroxidasin_like; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR047018; Peroxidasin_Ig-like3.
DR InterPro; IPR034828; Peroxidasin_Ig-like4.
DR InterPro; IPR034824; Peroxidasin_peroxidase.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF75; PEROXIDASIN HOMOLOG; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR619791-2};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 182..268
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 278..364
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 369..456
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 457..546
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1349..1407
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1278..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1325..1352
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1278..1297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1010
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1415 AA; 158486 MW; 9B520B03E2522F88 CRC64;
MLTDLRFNRI REIQPGAFRR LRNLNTLLLN NNQIKRIPSG AFEDLENLKY LYLYKNEIQS
IDRQAFKGLA SLEQLYLHFN QIETLDPESF QHLPKLERLF LHNNRITHLV PGTFNHLESM
KRLRLDSNTL HCDCEILWLA DLLKTYAESG NAQAAATCEY PRRIQGRSVA AVTPEELNCE
RPRITSEPRD ADVTSGNTVY FTCRAEGNPK PEIIWLRNNN ELSMKTDSRL NLLDDGTLMI
QNTQETDQGI YQCMAKNVAG EVKTQEVTLR YFGSPARPTF VIQPQNTEVL VGESVTLECS
ATGHPPPRIS WTRGDRTPLP VDPRVNITPS GGLYIQNVVQ EDSGEYACSA TNSIDSVHAT
AFIIVQALPQ FTVTPQDRVV IEGQTVDFQC EAKGNPPPVI AWTKGGSQLS VDRRHLVLSS
GTLRISGVAL HDQGQYECQA VNIIGSQKVV AHLTVQPRVT PVFASIPSDT TVEVGANVQL
PCSSQGEPEP AITWNKDGVQ VTESGKFHIS PEGFLTINDV GPADAGRYEC VARNTIGSAS
VSMVLSVNVP DVSRNGDPFV ATSIVEAIAT VDRAINSTRT HLFDSRPRSP NDLLALFRYP
RDPYTVEQAR AGEIFERTLQ LIQEHVQHGL MVDLNGTSYH YNDLVSPQYL NLIANLSGCT
AHRRVNNCSD MCFHQKYRTH DGTCNNLQHP MWGASLTAFE RLLKSVYENG FNTPRGINPH
RLYNGHALPM PRLVSTTLIG TETVTPDEQF THMLMQWGQF LDHDLDSTVV ALSQARFSDG
QHCSSVCSND PPCFSVMIPP NDSRARSGAR CMFFVRSSPV CGSGMTSLLM NSVYPREQIN
QLTSYIDASN VYGSTEHEAR SIRDLASHRG LLRQGIVQRS GKPLLPFAAG PPTECMRDEN
ESPIPCFLAG DHRANEQLGL TSMHTLWFRE HNRVAAELLK LNPHWDGDTI YYETRKIVGA
EIQHITYQHW LPKILGEVGM RTLGEYQGYD PGINAGIFNA FATAAFRFGH TLVNPLLYRL
DENFQPLAQG HLPLHKAFFS PFRIVNEGGI DPLLRGLFGV AGKMRVPSQL LNTELTERLF
SMAHTVALDL AAINIQRGRD HGIPPYHDYR VYCNLSAAHT FEDLKNEIKN PEIREKLKRL
YGSTLNIDLF PALMVEDLVP GSRLGPTLMC LLSTQFKRLR DGDRLWYENP GVFSPAQLTQ
IKQTSLARIL CDNADNITRV QSDVFRVAEF PHGYGSCDEI PRVDLRVWQD CCEDCRTRGQ
FNAFSYHFRG RRSLEFSYQE DQPTKKTRPR KIPSVGRHGE HLSNSTSAFS TRSDTPGTND
FREFVLEMQK TITDLRTQIK KLESRLSTTE CVDAGGESYA NNTKWKKDAC TICECKDGQV
TCFVEACPPA TCAVPTNIPG ACCPVCLQRR SEEKP
//
