GenomeNet

Database: UniProt
Entry: A0A2I3M0B0_PAPAN
LinkDB: A0A2I3M0B0_PAPAN
Original site: A0A2I3M0B0_PAPAN 
ID   A0A2I3M0B0_PAPAN        Unreviewed;      4870 AA.
AC   A0A2I3M0B0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 7.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPANP00000029168};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPANP00000029168};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000029168, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000029168, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000029168}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02030730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000049498; ENSPANP00000029168; ENSPANG00000019876.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000028761; Chromosome 7.
DR   ExpressionAtlas; A0A2I3M0B0; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4187   4211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4411   4431       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4479   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4610   4628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4671   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4774       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3919   3954       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3219   3239       {ECO:0000256|SAM:Coils}.
FT   COILED     4333   4360       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4870 AA;  552202 MW;  0512276577409303 CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSLSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK ADTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID
     GTMDSPPCLK VTHKTFGTQH SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ESERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRAGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVATGEEHQ
     KQSPEIPLES LRTKALSMLT EAVQWSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSA ETEEGTEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED
     TSWTGKLRAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDAELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISHAS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGEIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLSTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALGLEEPDLE
     KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTE ADEEEEEIVH
     MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP
     SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
     TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTDHCTS LIDSTLQTIY RLSKGRSLTK
     AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL
     PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT
     RITATLEKQI SVDADGNFDP KPINTVNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY
     GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
     NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG
     GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGVIVSR GMKDMELDAS SMEKRFAYKF
     LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHRLYFLS
     SPLKPLSSSG YASHKEKEMV ASLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT
     VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI
     LTSIFEHVAQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECVASLAA
     AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGIPDTVEDM CPDIPQLEGL MKEINDLAES
     GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGQC CTKVTSEHLS LILGNILKII
     NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLRADG
     KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI
     LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER KKTKRRGDLY
     SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYGHR DTDEEVREHL RNNLHLQEKS
     DDPAVKWQLN LYKDVLKSEE PFNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS
     KQRKRAVVAC FRMAPLYNLP RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE
     EEEEETKKQP DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK
     EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN
     AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE
     RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES
     ISDFYWYYSG KDIIDESGQH NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV
     VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV
     ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS KREFQKAMEG QKQYTQSEID
     FLLSCAEADE NDMFNYIDFV DRFHEPAKDI GFNVAVLLTN LSEHMPNDSR LKCLLDPAES
     VLNYFEPYLG RIEIMGGAKK IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE
     KMELFVNFCE DTIFEMQLAS QISESDSADR PEEEEEDEDS SYVLEIAGEE EEDGSFEPAS
     AFAMACASVK RNVADFLKRA TLKNLRKQYR NVKKMTAKEL VKVLCSFFWM LFLGLFQMLF
     TILGGIFQIL WSTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDTMEA ERAEVMEPGI
     TTELVHFIKG EKGDTDIMSD LFGLHPKKEG SLKHGPEVGL GDLSEIIGKD EPPTLESTVQ
     KKRKAQAAEM KAANEAEGKV ESEKADMEDG EKEDKDKEEE QAEHLWTEVT KKKKRRCGQK
     AEKPEAFTAN FFKGLDIYQT KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE
     ETEDVANLWN SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV
     PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN
     KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW LSSIDMKYHI WKLGVVFTDN
     SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
     PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY
     FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC
     FRKQYEDQLG
//
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