ID A0A2I3M229_PAPAN Unreviewed; 685 AA.
AC A0A2I3M229;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Actinin alpha 2 {ECO:0000313|Ensembl:ENSPANP00000029765.2};
GN Name=ACTN2 {ECO:0000313|Ensembl:ENSPANP00000029765.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000029765.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000029765.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000029765.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2I3M229; -.
DR Ensembl; ENSPANT00000051376.2; ENSPANP00000029765.2; ENSPANG00000019888.3.
DR GeneTree; ENSGT00940000153968; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000019888; Expressed in gastrocnemius and 51 other cell types or tissues.
DR ExpressionAtlas; A0A2I3M229; baseline.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF429; ALPHA-ACTININ-2; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 544..579
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 580..615
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 63..90
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 228..311
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 462..496
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 685 AA; 79664 MW; 7A08058F1972DEB7 CRC64;
MTYVSCFYHA FAGAEQVRQS LKAHSALWKD PPESSTYSYQ EMRRSSVHSS AMAETAANRI
CKVLAVNQEN ERLMEEYERL ASELLEWIRR TIPWLENRTP EKTMKAMQKK LEDFRDYRRK
HKPPKVQEKC QLEINFNTLQ TKLRISNRPA FMPSEGKMVS DIAGAWQRLE QAEKGYEEWL
LNEIRRLERL EHLAEKFRQK ASTHETWAYG KEQILLQKDY ESASLTEVRA LLRKHEAFES
DLAAHQDRVE QIAAIAQELN ELDYHDAVNV NDRCQKICDQ WDRLGTLTQK RREALERMEK
LLETIDQLHL EFAKRAAPFN NWMEGAMEDL QDMFIVHSIE EIQSLITAHE QFKATLPEAD
GERQSIMAIQ NEVEKVIQSY SIRISSSNPY STVTMDELRT KWDKVKQLVP IRDQSLQEEL
ARQHANERLR RQFAAQANAI GPWIQNKMEE IARSSIQITG ALEDQMNQLK QYEHNIINYK
NNIDKLEGDH QLIQEALVFD NKHTNYTMEH IRVGWELLLT TIARTINEVE TQILTRDAKG
ITQEQMNEFR ASFNHFDRRK NGLMDHEDFR ACLISMGYDL GEAEFARIMT LVDPNGQGTV
TFQSFIDFMT RETADTDTAE QVIASFRILA SDKPYILAEE LRRELPPDQA QYCIKRMPAY
SGPGSVPGAL DYTAFSSALY GESDL
//
