ID A0A2I3M7V0_PAPAN Unreviewed; 1928 AA.
AC A0A2I3M7V0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Tenascin C {ECO:0000313|Ensembl:ENSPANP00000031805.2};
GN Name=TNC {ECO:0000313|Ensembl:ENSPANP00000031805.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000031805.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000031805.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000031805.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPANT00000052026.2; ENSPANP00000031805.2; ENSPANG00000025804.3.
DR GeneTree; ENSGT00940000155188; -.
DR OrthoDB; 5489847at2759; -.
DR Proteomes; UP000028761; Chromosome 13.
DR Bgee; ENSPANG00000025804; Expressed in adrenal cortex and 62 other cell types or tissues.
DR ExpressionAtlas; A0A2I3M7V0; baseline.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00063; FN3; 11.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR Pfam; PF07974; EGF_2; 4.
DR Pfam; PF18720; EGF_Tenascin; 9.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 12.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 12.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 11.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1928
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035225341"
FT DOMAIN 280..311
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 625..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 805..894
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 895..990
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 991..1075
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1076..1165
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1167..1257
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1258..1347
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1349..1438
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1439..1528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1529..1615
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1616..1704
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1702..1917
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 284..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 301..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 377..387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 394..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1928 AA; 211173 MW; FF1FDB4467A90848 CRC64;
MGAMTRLWAG VLLALLALLT EGGVLKKVIR HKRQSGVNIT LPEENQPVVF NHVYNIKLPV
GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK
ELLSRLEELE NLVSSLREQC AAGAGCCLQS AIGRVDTRPF CSGRGNFSTE GCGCVCEPGW
KGPNCSEPEC PGNCNLRGQC IDGQCICDEG FTGEDCSQLA CPGDCNDQGK CVNGVCICFE
GYAGADCSQE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKLTCPHAC HGQGRCEEGQ
CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG QCECDDGFTG ADCGELKCPN GCSGHGRCVN
GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV QGKCVCEQGF KGYDCSDMSC PNDCHQHGRC
VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGR CVDGQCICED GFTGPDCAEL SCPNDCHGRG
RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCMDGQCIC HEGFTGLDCG QRSCPSDCSN
LGQCVSGRCI CNEGYAGEDC SEVSPPKDLI VTEVTEETVN LAWDNEMRVT EYLVVYTPTH
EGGLEMQFRV PGDQTSTIIR ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF
KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE
ISLHIVKNNT RGPGLKRVTT TRLDAPSQME VKDVTDTTAL ITWFKPLAEI DGIELTYGIK
DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR
RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE
YGIGVSAVKE DKESNPATIN AATELDTPKD LRVSETAETS LTLFWKTPLA KFDRYRLNYS
LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TEQAPELENL
TVTEVGWDGL RLNWTAADQA YEHFVIQVQE ANKVEAAQNL TVPGNLRAVD IPGLKAATPY
TVSIYGVIQG YRTPVLSAEA STGETPNLGE VMVAEVGWDA LKLNWTVPEG AYEYFFIQVQ
EADTVEAAQN HTVPGGLRST DLPGLKAATR YTITIRGVTQ DFSTTPLSVE VLTAKEPEIG
NLNVSDITPE SFSLSWTATD GIFETFTIEI IDSNRLLEIV EYNISGAERT AHISGLPPST
DFIVYLSGLA PSIRTKTISA TATTEAEPEV DNLLVSDATP DGFRLSWTAD EGVFDNFVLK
IRDTKKQSEP LEITLLAPER TRDITGLREA TEYEIELYGI SKGKRSQPVS AIATTAMGSP
REVIFSDITE NSATVSWRAP TAQVESFRIT YVPITGGTPS MVTVDGTKTQ TRLVKLVPGV
EYLVNIIAMK GFEESEPVSG SFTTALDGPS GLVTANITDS EALARWQPAI ATVDSYVISY
TGEKVPEITR TVSGNTVEYA LTDLEPATEY TLRIFAEKGP QKSSTVTAKF TTDLDSPRDL
TATEVQSETA LLTWRPPRAS VTGYLLVYES VDGTVKEVIV GPDTTSYSLV DLSPSSHYTA
KIQALNGPLR SNMIQTIFTT IGLLYPFPKD CSQAMLNGDT TSGLYTIYLN GDKAQALEVF
CDMTSDGGGW IVFLRRKNGH ENFYQNWKAY AAGFGDRREE FWLGLDNLNK ITAQGQYELR
VDLRDHGETA FAVYDKFSVG DAKTRYKLKV EGYSGTAGDS MAYHNGRSFS TFDKDTDSAI
TNCALSYKGA FWYRNCHRVN LMGRYGDNNH SQGVNWFHWK GHEHSIQFAE MKLRPSNFRN
LEGRRKRA
//
