ID A0A2I3MGB3_PAPAN Unreviewed; 1377 AA.
AC A0A2I3MGB3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSPANP00000034625.2};
GN Name=ARAP3 {ECO:0000313|Ensembl:ENSPANP00000034625.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000034625.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000034625.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000034625.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSPANT00000047077.2; ENSPANP00000034625.2; ENSPANG00000024671.4.
DR GeneTree; ENSGT00940000158869; -.
DR Proteomes; UP000028761; Chromosome 5.
DR Bgee; ENSPANG00000024671; Expressed in lung and 64 other cell types or tissues.
DR ExpressionAtlas; A0A2I3MGB3; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17902; ArfGap_ARAP3; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 209..301
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 316..405
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 402..533
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 736..921
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 950..1043
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1056..1158
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1377
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 151413 MW; 588ADE3313AF0F54 CRC64;
MEPSSSPAPQ IQPPKPVPKP RTVFGGLSGP ATTQRPGLSP VLGEPGVSRS PEPSPRPPPL
PTSSTEQSSA LNTVEMMPNS IYFGLDLRGR AQAAQEKAPD SSQTTAPTPA LRPTAGTVHI
MDPGCLYYGV QPVGTPGAPD RREGRGVCQD RAEHRLSRQD LEAREDAGYA SLELPGDSTL
SSPTLETEET SDDLISPYAS FSFTADRPTP LLSGWLDKLS PQGNYVFQRR FVQFNGRSLM
YFGSDKDPFP KGVIPLTAIE MTRSSKDNKF QVITGQRVFV FRTESEAQRD TWCSTLQSCL
KEQRLLGHPR PPQPPRPLRT GMLELRGHKA KVFAALSPGE LALYKSEQAF SLGIGICFIE
LQGCSVRETK SRSFDLLTPH RCFSFTAESG GARQSWAAAL QEAVTETLSD YEVAEKIWSN
RANRHCADCG SSRPDWAAVN LGVVICKQCA GQHRALGSGI SKVQSLKLDT SVWSNEIVQL
FIVLGNDRAN RFWAGTLPPG EGLHPDATPG LRGEFISRKY RLGLFRKPHP QYPDHSQLLQ
ALCAAVAGPN LLKNMTQLLC VEAFEDPSPG VYNEVVVPAT YSGFLYCGPV TNKAGPSPPR
RGRDAPPRLW CVLGAALEMF ASENSPEPLS LIQPQDIVCL GVSPPPTDPG DLDRFPFSFE
LILTGGRIQH FGTDGADSLE AWTSAVGKWF SPLSCHQLLG PGLLRLGRLW LRSPSHTAPA
PGVWLSGFGL LRGDHLFLCS APGPGPPAPE DMVHLRRLQE ISVVSAADTP DKKEYLVLVE
TGRTLYLQGE GRLDFTAWNT AIGGAAGGGG TGLQEQQMSR GDIPIIVDAC ISFVTQHELP
QKNQRLQKYK DVIGCLPRVN RRTLATLIGH LYRVQKCAAL NQMCTRNLAL LFAPSVFQTD
GRGEHEVRVL QELIDGYISV FDIDSDQVAQ IDLEVSLITT WKDVQLSQAG DLIMEVYIEQ
QLPDNCVTLK VSPTLTAEEL TNQVLEMRGT AAGMDLWVTF EIREHGELER PLHPKEKVLE
QALQWCQLPE PCSASLLLKK VPLAQAGCLF TGIRRESPRV GLLRCREEPP RLLGSRFQER
FFLLRGRCLL LLKEKKSSKP EREWPLEGAK VFLGIRKKLK PPTPWGFTLI LEKMHLYLSC
TDEDEMWDWT TSILKAQHDD QQPVVLRRRS SSDLARQKFG TMPLLPIRGD DSGATLLSAN
QTLRQLHNRR TLSMFFPMKS SQGSVEEQEE LEEPVYEEPV YEEVGAFPEL TQDTSTSFST
TREWTVKPEN PLTSQKSLDQ PFLSKSSTLG QEERLPEPPP GPLSKSSPQA RGSLEEQLLQ
ELSSLILRKG ETTAGLGSPS QPSSPQSPSP TGLPTQTPGF PTQPPCTSSP PSSHPLT
//