ID A0A2I3MHC5_PAPAN Unreviewed; 1272 AA.
AC A0A2I3MHC5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSPANP00000035138.2};
GN Name=ARHGEF10L {ECO:0000313|Ensembl:ENSPANP00000035138.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000035138.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000035138.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000035138.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2I3MHC5; -.
DR Ensembl; ENSPANT00000038709.2; ENSPANP00000035138.2; ENSPANG00000011205.3.
DR GeneTree; ENSGT00940000153798; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000011205; Expressed in aorta and 65 other cell types or tissues.
DR ExpressionAtlas; A0A2I3MHC5; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 314..501
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..514
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..46
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1272 AA; 139678 MW; 3120BB017F33C14E CRC64;
MASSNPPPQP AIGDQLVPGA PGPSSEVEDD PGEAFEFDDS DDEEDTSAAL GVPSLAPERD
TDTPLIHFDP IPVTDPDPAA APPSTEVPAW VSNGDAADAA FSGARHSSWK RKSSRRIDRF
TFPALEEDVI YDDVPCESPD AHQPGAERNL LYEDAHRAGA PRQAEDLGWS SSEFESYSED
SGEEAKPEVE PTKHRVSFQP KLSPDLTRLK ERYARTKRDI LALRVGGRDM QELKHKYDCK
MTQLMKAAKS GTKDGLEKTR MAVMRKVSFL HRKDVLGDSE EEDMGLLEVS VSDIKPPAPE
LGPMPEGLSP QQVVRRHILG SIVQSEGSYV ESLKRILQDY RNPLMEMEPK ALSARKCQVV
FFRVKEILHC HSMFQIALSS RVAEWDSTEK IGDLFVASFS KSMVLDVYSD YVNNFTSAMS
IIKKACLTKP AFLEFLKRRQ VCSPDRVTLY GLMVKPIQRF PQFILLLQDM LKNTPRGHPD
RLSLQLALTE LETLAEKLNE QKRLADQVAE IQQLTKSVSD RSSLNKLLTS GQRQLLLCET
LTETVYGDRG QLIKSKERRV FLLNDMLVCA NINFKGQLEI SSLVPLGPKY VVKWNTALPQ
VQVVEVGQDG GTYDKDNVLI QHAGAKKAST SGQAQNKVYL GPPRLFQELQ DLQKDLAVVE
QITLLISTLH GTYQNLNMTV AQDWCLALQR LMRVKEEEIH SANKCRLRLL LPGKPDKSGR
PISFMVVFIT PNPLSKISWV NRLHLAKIGL REENQPGWLC PDEDKKSKAP FWCPILACCI
PAFSSRALSL QLGALVHSPV NCPLLGFSAV STSLPQGYLW VGGGQEGAGG QVEIFSLNRP
SPRTVKSFPL AAPVLCMEYI PELEEEAESR DDSRTAADPS ATVHPTICLG LQDGSILLYG
SVDTGTQCLA TCRSPGLQPV LCLRHSPFHL LAGLQDGTLA AYPRTSGGVL WDLESPPVCL
TVGPGPVRTL LSLEDAVWAS CGPRVSVLEA TTLQPQQSFE AHQDEAVSVT HMVKAGSGVW
MAFSSGTSIR LFHTETLEHL QEINIATRTT FLLPGQKHLC VTSLLICQGL LWVGTDQGVI
VLLPVPRLEG IPKITGKGMV SLNGHCGPVA FLAVATSILA PDILRSDQEE AEGPRAEEDK
PDGQAHEPVP DSHVGRELTR KKGILLQYRL RSTAHLPGPL LSMREPAPAD GAALEHSEED
GSIYEMADDP DVWVRSRPCA RDAHRKEICS VAIISGGQGY RNFGSPLGSS GRPAPCGETD
STLLIWQVPL ML
//
