ID A0A2I3MSB8_PAPAN Unreviewed; 2823 AA.
AC A0A2I3MSB8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSPANP00000038644.2};
GN Name=TENM4 {ECO:0000313|Ensembl:ENSPANP00000038644.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000038644.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000038644.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000038644.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPANT00000039528.2; ENSPANP00000038644.2; ENSPANG00000004552.3.
DR GeneTree; ENSGT01030000234566; -.
DR OMA; HWTQSAP; -.
DR Proteomes; UP000028761; Chromosome 12.
DR Bgee; ENSPANG00000004552; Expressed in postnatal subventricular zone and 29 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0060912; P:cardiac cell fate specification; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0032289; P:central nervous system myelin formation; IEA:Ensembl.
DR GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:2000543; P:positive regulation of gastrulation; IEA:Ensembl.
DR GO; GO:0031643; P:positive regulation of myelination; IEA:Ensembl.
DR GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011048; Haem_d1_sf.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 2.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF51004; C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 411..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..411
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 696..728
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 857..892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 718..727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 861..871
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 882..891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2823 AA; 312907 MW; E00340F63AA86E75 CRC64;
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKTPQKSYS SSETLKAYDQ DARLAYGSRV
KDMVPQEAEE FCRTGANFTL RELGLGEVTS PHGTLYRTDI GLPHCGYSMG ASSDADMEAD
TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETGAPLHC SSASSTPIEQ
SPSPPPSPPA NESQRRLLGN GVAQPTPDSD SEEEFVPNSF LVKSGSASLG VAANDHPGGL
QNHARLRTPP PPLSHTHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPASGAQ
EPAHAQDNWL LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY GDGHFLFKPG
GTSPLFCTTS PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS
ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD
RKGKGTAEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL
GKAALVGIYG RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGA VPPSSHETGF
IQYLDSGIWH LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP
DCGRASCPVL CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CIMGTCICNP
GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT
GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC
RDGKCECSPG WNGEHCTIEG CPGLCNGNGR CTLDLNGWHC VCQLGWRGAG CDTSMETACG
DSKDNDGDGL VDCMDPDCCL QPLCHVNPLC LGSPDPLDII QETQVPVSQQ NLHSFYDRIK
FLVGRDSTHI IPGENPFDGG HACVIRGQVM TSDGTPLVGV NISFVNNPIF GYTISRQDGS
FDLVTNGGIS IILRFERAPF ITQEHTLWLP WDRFFVMETI IMRHEENEIP SCDLSNFARP
NPVVSPSPLT SFASSCAEKG PIVPEIQALQ EEISIAGCKM RLSYLSSRTP GYKSVLRISL
THPTIPFNLM KVHLMVAVEG RLFRKWFAAA PDLSYYFIWD KTDVYNQKVF GLSEAFVSVG
YEYESCPDLI LWEKRTAVLQ GYEIDASKLG GWSLDKHHAL NIQSGILHKG NGENQFVSQQ
PPVIGSIMGN GRRRSISCPS CNGLADGNKL LAPVALTCGS DGSLYVGDFN YIRRIFPSGN
VTNILELSHS PAHKYYLTTD PMSGAVFLSD TNSRRVFKIK STVVVKDLVK NSEVVAGTGD
QCLPFDDTRC GDGGKATEAT LTNPRGITVD KFGLIYFVDG TMIRRIDQNG IISTLLGSND
LTSARPLSCD SVMDISQVRL EWPTDLAINP MDNSLYVLDN NVVLQISENH QVRIVAGRPM
HCQVPGIDHF LLSKVAIHAT LESATALAVS HNGVLYIAET DEKKINRIRQ VTTSGEISLV
AGAPSGCDCK NDANCDCFSG DDGYAKDAKL NTPSSLAVCA DGELYVADLG NIRIRFIRKN
KPFLNTQNMY ELSSPIDQEL YLFDTTGKHL YTQSLPTGDY LYNFTYTGDG DVTLITDNNG
NMVNVRRDST GMPLWLVVPD GQVYWVTMGT NSALKSVTTQ GHELAMMTYH GNSGLLATKS
NENGWTTFYE YDSFGRLTNV TFPTGQVSSF RSDTDSSVHV QVETSSKDDV TITTNLSASG
AFYTLLQDQV RNSYYIGADG SLRLLLANGM EVALQTEPHL LAGTVNPTVG KRNVTLPIDN
GLNLVEWRQR KEQARGQVTV FGRRLRVHNR NLLSLDFDRV TRTEKIYDDH RKFTLRILYD
QAGRPSLWSP SSRLNGVNVT YSPGGHIAGI QRGIMSERME YDQAGRIISR IFADGKTWSY
TYLEKSMVLL LHSQRQYIFE FDKNDRLSSV TMPNVARQTL ETIRSVGYYR NIYQPPEGNA
SVIQDFTEDG HLLHTFYLGT GRRVIYKYGK LSKLAETLYD TTKVSFTYDE TAGMLKTINL
QNEGFTCTIR YRQIGPLIDR QIFRFTEEGM VNARFDYNYD NSFRVTSMQA VINETPLPID
LYRYDDVSGK TEQFGKFGVI YYDINQIITT AVMTHTKHFD AYGRMKEVQY EIFRSLMYWM
TVQYDNMGRV VKKELKVGPY ANTTRYSYEY DADGQLQTVS INDKPLWRYS YDLNGNLHLL
SPGNSARLTP LRYDLRDRIT RLGDVQYKMD EDGFLRQRGG DIFEYNSAGL LIKAYNRAGG
WSVRYRYDGL GRRVSSKSSH SHHLQFFYAD LTNPTKVTHL YNHSSSEITS LYYDLQGHLF
AMELSSGDEF YIACDNIGTP LAVFSGTGLM IKQILYTAYG EIYMDTNPNF QIIIGYHGGL
YDPLTKLVHM GRRDYDVLAG RWTSPDHELW QHLSSSNIMP FNLYMFKNNN PISNSQDIKC
FMTDVNSWLL TFGFQLHNVI PGYPKPDMDA MEPSYELIHT QMKTQEWDNS KSILGVQCEV
QKQLKAFVTL ERFDQLYGST ITSCQQAPKT KKFASSGSIF GKGVKFALKD GRVTTDIISV
ANEDGRRVAA ILNNAHYLEN LHFTIDGVDT HYFVKPGPSE GDLAILGLSG GRRTLENGIN
VTVSQINTVL NGRTRRYTDI QLQYGALCLN TRYGTTLDEE KARVLELARQ RAVRQAWARE
QQRLREGEEG LRAWTEGEKQ QVLSTGRVQG YDGFFVISVE QYPELSDSAN NIHFMRQSEM
GRR
//
