GenomeNet

Database: UniProt
Entry: A0A2I3MSI8_PAPAN
LinkDB: A0A2I3MSI8_PAPAN
Original site: A0A2I3MSI8_PAPAN 
ID   A0A2I3MSI8_PAPAN        Unreviewed;      4833 AA.
AC   A0A2I3MSI8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 7.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPANP00000038714};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPANP00000038714};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000038714, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000038714, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000038714}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02030730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02030735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000052591; ENSPANP00000038714; ENSPANG00000019876.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000028761; Chromosome 7.
DR   ExpressionAtlas; A0A2I3MSI8; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4158   4182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4382   4402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4450   4469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4581   4599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4642   4663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4722   4745       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      586    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1255   1467       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3890   3925       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      460    480       {ECO:0000256|SAM:Coils}.
FT   COILED     3206   3226       {ECO:0000256|SAM:Coils}.
FT   COILED     4304   4331       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4833 AA;  547966 MW;  762FDB54C94DAF88 CRC64;
     GLAQQFPILM FGSLFSPQED EVVLQCIATI HKEQRKFCLA AEGLGNRLCF LEPTSEAKYI
     PPDLCVCNFV LEQSLSVRAL QEMLANTGEN GGEGAAQGGG HRTLLYGHAI LLRHSFSGMY
     LTCLTTSRSQ TDKLAFDVGL REHATGEACW WTIHPASKQR SEGEKVRIGD DLILVSVSSE
     RYLHLSLSNG NIQVDASFMQ TLWNVHPTCS GSSIEEGYLL GGHVVRLFHG HDECLTIPST
     DQNDSQHRRI FYEAGGAGTR ARSLWRVEPL RISWSGSNIR WGQAFRLRHL TTGHYLALTE
     DQGLILQDRA KADTKSTAFS FRASKELKEK LDSSHKRDIE GMGVPEIKYG DSVCFVQHIA
     SGLWVTYKAQ DAKTSRLGPL KRKVILHQEG HMDDGLTLQR CQREESQAAR IIRNTTALFS
     QFVSGNNRTA APITLPIEEV LQTLQDLIAY FQPPEEEMRH EDKQNKLRSL KNRQNLFKEE
     GMLALVLNCI DRLNIYNSVA HFAGIAREES GMAWKEILNL LYKLLAALIR GNRNNCAQFS
     NNLDWLISKL DRLESSSGIL EVLHCILTES PEALNLIAEG HIKSIISLLD KHGRNHKVLD
     ILCSLCLCNG VAVRANQNLI CDNLLPRRNL LLQTRLINDV TSIRPNIFLG VAEGSAQYKK
     WYFELIIDQV DPFLTAEPTH LRVGWASSSG YAPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WSGRIPRAVA SINQHLLRSD DVVSCCLDLG VPSISFRING QPVQGMFENF NTDGLFFPVM
     SFSAGVKVRF LMGGRHGEFK FLPPSGYAPC YEALLPKEKM RLEPVKEYKR DADGVRDLLG
     TTQFLSQASF IPCPIDTSQV VLPPHLEKIR DRLAENIHEL WGMNKIELGW TFGKIRDDNK
     RQHPCLVEFS KLPETEKNYN LQMSTETLKT LLALGCHIAH VNPAAEEDLK KVKLPKNYMM
     SNGYKPAPLD LSDVKLLPPQ EILVDKLAEN AHNVWAKDRI KQGWTYGIQQ DLKNKRNPRL
     VPYALLDERT KKSNRDSLRE AVRTFVGYGY NIEPSDQELA DSAVEKVSID KIRFFRVERS
     YAVRSGKWYF EFEVVTGGDM RVGWARPGCR PDVELGADDQ AFVFEGSRGQ RWHQGSGYFG
     RTWQPGDVVG CMINLDDASM IFTLNGELLI TNKGSELAFA DYEIENGFVP ICCLGLSQIG
     RMNLGTDAST FKFYTMCGLQ EGFEPFAVNM NRDVAMWFSK RLPTFVNVPK DHPHIEVMRI
     DGTMDSPPCL KVTHKTFGTQ HSNADMIYCR LSMPVECHSS FSHSPCLDSE AFQKRKQMQE
     ILSHTTTQCY YAIRIFAGQD PSCVWVGWVT PDYHLYSEKF DLNKNCTVTV TLGDERGRVH
     ESVKRSNCYM VWGGDIVASS QRSNRSNVDL EIGCLVDLAM GMLSFSANGK ELGTCYQVEP
     NTKVFPAVFL QPTSTSLFQF ELGKLKNAMP LSAAIFKSEE KNPVPQCPPR LDVQTIQPVL
     WSRMPNSFLK VESERVSERH GWVVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMRFHY
     HTLRLYSAVC ALGNSRVAYA LCSHVDLSQL FYAIDNKYLP GLLRAGFYDL LISIHLANAK
     ERKLMMKNEY IIPITSTTRN IRLFPDESKR HGLPGVGLRT CLKPGFRFST PCFVATGEEH
     QKQSPEIPLE SLRTKALSML TEAVQWSGAH IRDPVGGSVE FQFVPVLKLI GTLLVMGVFD
     DDDVRQILLL IDPSVFGEHS AETEEGTEKE EVTQVEEKAV EAGEKAGKEA PVKGLLQTRL
     PESVKLQMCE LLSYLCDCEL QHRVEAIVAF GDIYVSKLQA NQKFRYNELM QALNMSAALT
     ARKTKEFRSP PQEQINMLLN FQLGENCPCP EEIREELYDF HEDLLLHCGV PLEEEEEEEE
     DTSWTGKLRA LVYKIKGPPK PEKEQPTEEE ERCPTTLKEL ISQTMICWAQ EDQIQDAELV
     RMMFNLLRRQ YDSIGELLQA LRKTYTISHA SVSDTINLLA ALGQIRSLLS VRMGKEEELL
     MINGLGEIMN NKVFYQHPNL MRVLGMHETV MEVMVNVLST EKSQIAFPKM VASCCRFLCY
     FCRISRQNQK AMFEHLSYLL ENSSVGLASP SMRGSTPLDV AASSVMDNNE LALGLEEPDL
     EKVVTYLAGC GLQSCPMLLA KGYPDVGWNP IEGERYLSFL RFAVFVNSES VEENASVVVK
     LLIRRPECFG PALRGEGGNG LLAAMQGAIK ISENPALDLP SQGYKREVTE ADEEEEEIVH
     MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP
     SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
     TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTDHCTS LIDSTLQTIY RLSKGRSLTK
     AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL
     PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT
     RITATLEKQI SVDADGNFDP KPINTVNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY
     GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
     NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQVKPNVTS HLTDPGGGSH PLLVPYDTLT
     AKEKFKDREK AQDLFKFLQV NGVIVSRGMK DMELDASSME KRFAYKFLKK ILKYVDSAQE
     FIAHLEAIVS SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN HRLYFLSSPL KPLSSSGYAS
     HKEKEMVASL FCKLAALVRH RISLFGSDST TMVSCLHILA QTLDTRTVMK SGSELVKAGL
     RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT TVALLPILTS IFEHVAQHQF
     GMDLLLGDVQ ISCYHILCSL YSLGTGKNIY VERQRPALGE CVASLAAAIP VAFLEPTLNR
     YNPLSVFNTK TPRERSILGI PDTVEDMCPD IPQLEGLMKE INDLAESGAR YTEMPHVIEV
     ILPMLCNYLS YWWERGPENL PPSTGQCCTK VTSEHLSLIL GNILKIINNN LGIDEASWMK
     RIAVYAQPII SKARPDLLRS HFIPTLEKLK KKAVKTVQEE EQLRADGKGD TQEAELLILD
     EFAVLCRDLY AFYPMLIRYV DNNRSNWLKS PDADSDQLFR MVAEVFILWC KSHNFKREEQ
     NFVIQNEINN LAFLTGDSKS KMSKSGGQDQ ERKKTKRRGD LYSIQTSLIV AALKKMLPIG
     LNMCTPGDQE LISLAKSRYG HRDTDEEVRE HLRNNLHLQE KSDDPAVKWQ LNLYKDVLKS
     EEPFNPEKTV ERVQRISAAV FHLEQVEQPL RSKKAVWHKL LSKQRKRAVV ACFRMAPLYN
     LPRHRSINLF LHGYQRFWIE TEEYSFEEKL VQDLAKSPKV EEEEEEETKK QPDPLHQIIL
     YFSRNALTER RSEPPDHLCQ SGEDEEEDED KEKTFEEKEM EKQKTLYQQA RLHERGAAEM
     VLQMISASKG EMSPMVVETL KLGIAILNGG NAGVQQKMLD YLKEKKDAGF FQSLSGLMQS
     CSVLDLNAFE RQNKAEGLGM VTEEGTLIVR ERGKFQFLND EFTRDLFRFL QLLCEGHNSD
     FQNFLRTQMG NTTTVNVIIS TVDYLLRLQE SISDFYWYYS GKDIIDESGQ HNFSKALAVT
     KQIFNSLTEY IQGPCIGNQQ SLAHSRLWDA VVGFLHVFAN MQMKLSQDSS QIELLKELLD
     LLQDMVVMLL SLLEGNVVNG TIGKQMVDTL VESSTNVEMI LKFFDMFLKL KDLTSSDTFK
     EYDPDGKGII SKREFQKAME GQKQYTQSEI DFLLSCAEAD ENDMFNYIDF VDRFHEPAKD
     IGFNVAVLLT NLSEHMPNDS RLKCLLDPAE SVLNYFEPYL GRIEIMGGAK KIERVYFEIS
     ESSRTQWEKP QVKESKRQFI FDVVNEGGEQ EKMELFVNFC EDTIFEMQLA SQISESDSAD
     RPEEEEEDED SSYVLEIAGE EEEDGSFEPA SAFAMACASV KRNVADFLKR ATLKNLRKQY
     RNVKKMTAKE LVKVLCSFFW MLFLGLFQML FTILGGIFQI LWSTVFGGGL VEGAKNIRVT
     KILGDMPDPT QFGIHDDTME AERAEVMEPG ITTELVHFIK GEKGDTDIMS DLFGLHPKKE
     GSLKHGPEVG LGDLSEIIGK DEPPTLESTV QKKRKAQAAE MKAANEAEGK VESEKADMED
     GEKEDKDKEE EQAEHLWTEV TKKKKRRCGQ KAEKPEAFTA NFFKGLDIYQ TKLLHYLARN
     FYNLRFLALF VAFAINFILL FYKVTEEPLE EETEDVANLW NSFNDEEEEE AMVFFVLQES
     TGYMAPTLRA LAIIHTIISL VCVVGYYCLK VPLVVFKREK EIARKLEFDG LYITEQPSED
     DIKGQWDRLV INTPSFPNNY WDKFVKRKVI NKYGDLYGAE RIAELLGLDK NALDFSPVEE
     TKAEAASLVS WLSSIDMKYH IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN FFFAAHLLDI
     AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDDDEPDMKC
     DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DPYEMYRIVF DITFFFFVIV ILLAIIQGLI
     IDAFGELRDQ QEQVREDMET KCFICGIGND YFDTTPHGFE THTLQEHNLA NYLNKHPLFP
     FQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
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