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Database: UniProt
Entry: A0A2I3MSM3_PAPAN
LinkDB: A0A2I3MSM3_PAPAN
Original site: A0A2I3MSM3_PAPAN 
ID   A0A2I3MSM3_PAPAN        Unreviewed;      2715 AA.
AC   A0A2I3MSM3;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 7.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSPANP00000038749};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSPANP00000038749};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000038749, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000038749, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000038749}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; AHZZ02019869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02019870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02019871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02019872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02019873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000035121; ENSPANP00000038749; ENSPANG00000016086.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000028761; Chromosome 2.
DR   ExpressionAtlas; A0A2I3MSM3; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2240   2262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2274   2292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2361   2386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2406   2428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2536   2559       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    142       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      149    199       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      207    263       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    349       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      355    411       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1570   1590       {ECO:0000256|SAM:Coils}.
FT   COILED     2653   2694       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2715 AA;  309684 MW;  3933AD68F12F0524 CRC64;
     RRGFIMLTRL VLNSCPQVIY LNVCLFALLL DCLFKLCPMN RYSAQKQFWK AAKPGANSTT
     DAVLLNKLHH AADLEKKQNE TENRKLLGTV IQYGNVIQLL HLKSNKYLTV NKRLPALLEK
     NAMRVTLDEA GNEGSWFYIQ PFYKLRSIGD SVVIGDKVVL NPVNAGQPLH ASSHQLVDNP
     GCNEVNSVNC NTSWKIVLFM KWSDNKDDIL KGGDVVRLFH AEQEKFLTCD EHRKKQHVFL
     RTTGRQSATS ATSSKALWEV EVVQHDPCRG GAGYWNSLFR FKHLATGHYL AAEVDPDFEE
     ECLEFQPSVD PDQDASRSRL RNAQEKMVYS LVSVPEGNDI SSIFELDPTT LRGGDSLVPR
     NSYVRLRHLC TNTWVHSTNI PIDKEEEKPV MLKIGTSPVK EDKEAFAIVP VSPAEVRDLD
     FANDASKVLG SIAGKLEKGT ITQNERRSVT KLLEDLVYFV TGGTNSGQDV LEVVFSKPNR
     ERQKLMREQN ILKQIFKLLQ APFTDCGDGP MLRLEELGDQ RHAPFRHICR LCYRVLRHSQ
     QDYRKNQEYI AKQFGFMQKQ IGYDVLAEDT ITALLHNNRK LLEKHITAAE IDTFVSLVRK
     NREPRFLDYL SDLCVSMNKS IPVTQELICK AVLNPTNADI LIETKLVLSR FEFEGVSSTG
     ENALEAGEDE EEVWLFWRDS NKEIRSKSVR ELAQDAKEGQ KEDRDVLSYY RYQLNLFARM
     CLDRQYLAIN EISGQLDVDL ILRCMSDENL PYDLRASFCR LMLHMHVDRD PQEQVTPVKY
     ARLWSEIPSE IAIDDYDSSG ASKDEIKERF AQTMEFVEEY LRDVVCQRFP FSDKEKNKLT
     FEVVNLARNL IYFGFYNFSD LLRLTKILLA ILDCVHVTTI FPISKMAKGE ENKGSNVMRS
     IHGVGELMTQ VVLRGGGFLP MTPMAAAPEG NVKQAEPEKE DIMVMDTKLK IIEILQFILN
     VRLDYRISCL LCIFKREFDE SNSQTSETSS GNSSQEGPSN VPGALDFEHI EEQAEGIFGG
     RKENTPLDLD DHGGRTFLRV LLHLTMHDYP PLVSGALQLL FRHFSQRQEV LQAFKQVQLL
     VTSQDVDNYK QIKQDLDQLR SIVEKSELWV YKGQGPDETM DGASGENGHK KTEEGNNKSQ
     KHESTSSYNY RVVKEILIRL SKLCVQESAS VRKSRKQQQR LLRNMGAHAV VLELLQIPYE
     KAEDTKMQEI MRLAHEFLQN FCAGNQQNQA LLHKHINLFL NPGILEAVTM QHIFMNNFQL
     CSEINERVVQ HFVHCIETHG RNVQYIKFLQ TIVKAEGKFI KKCQDMVMAE LVNSGEDVLV
     FYNDRASFQT LIQMMRSERD RMDENSPLMY HIHLVELLAV CTEGKNVYTE IKCNSLLPLD
     DIVRVVTHED CIPEVKIAYI NFLNHCYVDT EVEMKEIYTS NHMWKLFENF LVDICRACNN
     TSDRKHADSI LEKYVTEIVM SIVTTFFSSP FSDQSTTLQT RQPVFVQLLQ GVFRVYHCNW
     LMPSQKASVE SCIRVLSDVA KSRAIAIPVD LDSQVNNLFL KSHNIVQKTA MNWRLSARNA
     ARRDSVLAAS RDYRNIIERL QDIVSALEDR LRPLVQAELS VLVDVLHRPE LLFPENTDAR
     RKCESGGFIC KLIKHTKQLL EENEEKLCIK VLQTLREMMT KDRGYGEKVL HFIFMVKPGF
     QELEPSPPLR QLEDHKRGEA LRQILVNRYY GNIRPSGRRE SLTSFGNGPL SPGGPSKPGG
     GGGGSGSSSM SRGEMSLAEV QCHLDKEGAS NLVIDLIMNA SSDRVFHESI LLAIALLEGG
     NTTIQHSFFC RLTEDKKSEK FFKVFYDRMK VAQQEIKATV TVNTSDLGNK KKDDEVDRDA
     PSRKKAKEPT TQITEEVRDQ LLEASAATRK AFTTFRREAD PDDHYQPGEG TQATADKTKD
     DLEMSAVITI MQPILRFLQL LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ FLDCICGSTT
     GGLGLLGLYI NEKNVALINQ TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN
     PLGKKRMDLV LELKNNASKL LLAIMESRHD SENAERILYN MRPKELVEVI KKAYMQGEVE
     FEDGENGEDG AASPRNVGHN IYILAHQLAR HNKELQSMLK PGGQVDGDEA LEFYAKHTAQ
     IEIVRLDRTM EQIVFPVPSI CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN
     WQKKLRAQPV LYWCARNMSF WSSISFNLAV LMNLLVAFFY PFKGVRGGTL EPHWSGLLWT
     AMLISLAIVI ALPKPHGIRA LIASTILRLI FSVGLQPTLF LLGAFNVCNK IIFLMSFVGN
     CGTFTRGYRA MVLDVEFLYH LLYLVICAMG LFVHEFFYSL LLFDLVYREE TLLNVIKSVT
     RNGRSIILTA VLALILVYLF SIVGYLFFKD DFILEVDRLP NETAVPETGE SLASEFLFSD
     VCRVESGENC SSPAPKEELV PAEETEQDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK
     PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG
     LERDKFDNKT VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIKERNLDWF
     PRMRAMSLVS SDSEGEQNEL RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL
     LGHPPHMNVN PQQPA
//
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