ID A0A2I3MTU7_PAPAN Unreviewed; 961 AA.
AC A0A2I3MTU7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Nuclear factor of activated T cells 4 {ECO:0000313|Ensembl:ENSPANP00000039184.2};
GN Name=NFATC4 {ECO:0000313|Ensembl:ENSPANP00000039184.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000039184.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000039184.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000039184.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2I3MTU7; -.
DR STRING; 9555.ENSPANP00000039184; -.
DR Ensembl; ENSPANT00000040765.2; ENSPANP00000039184.2; ENSPANG00000020004.3.
DR GeneTree; ENSGT00940000160923; -.
DR OMA; NMTAIDC; -.
DR Proteomes; UP000028761; Chromosome 7.
DR Bgee; ENSPANG00000020004; Expressed in aorta and 42 other cell types or tissues.
DR ExpressionAtlas; A0A2I3MTU7; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0031547; P:brain-derived neurotrophic factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0045333; P:cellular respiration; IEA:Ensembl.
DR GO; GO:0071285; P:cellular response to lithium ion; IEA:Ensembl.
DR GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0050774; P:negative regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:1902894; P:negative regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:2000297; P:negative regulation of synapse maturation; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0097084; P:vascular associated smooth muscle cell development; IEA:Ensembl.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF11; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 462..643
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 27..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..292
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..370
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..884
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 101433 MW; 78C2ECF2A6C0D287 CRC64;
MITTLPSLLP TSLASISHRV TNLNSLSHNP GLSKPDFPGN SSPGLPSSSS PGRDLGAPAG
SMGAASCEDE ELEFKLVFGE EKEAPPLGAG GLGEELDSED APPCCRLALG EPPPYGAAPI
GIPRPPPPRP GMHSPPPRPA PSPGTWESQP ARSVRLGGPG GGAGGAGGGR VLECPSIRIT
SISPTPEPPA ALEDNPDTWG DGSPRDYPPP EGFGGYREAG GQGGGAFFSP SPGSSSLSSW
SFFSDASDEA ALYAACDEVE SELNEAASRF GLGSPLPSPR ASPRPWTPED PWSLYGPSPG
GRGPEDNWLL LSAPGPTPAS PRPASPCGKR RYSSSGTPSS ASPALSRRGS LGEEGSEPPP
PPPLPLARDP GSPGPFDYVG APPAESIPQK TRRTSSEQAV ALPRSEEPAP CNGKLPLGAE
ESVAPPGGPR KEVAGMDYLA VPSPLAWSKA RIGGHSPIFR TSALPPLDWP LPSQYEQLEL
RIEVQPRAHH RAHYETEGSR GAVKAAPGGH PVVKLLGYSE KPLTLQMFIG TADERNLRPH
AFYQVHRITG KMVATASYEA VVSGTKVLEM TLLPENNMAA NIDCAGILKL RNSDIELRKG
ETDIGRKNTR VRLVFRVHVP QGGGKVVSVQ AASVPIECSQ RSAQELPQVE AYSPSACSVR
GGEELVLTGS NFLPDSKVVF IERGPDGKLQ WEEEATVNRL QSNEVTLTLT VPEYSNKRVS
RPVQVYFYVS NGRRKRSPTQ SFKFLPVICK EEPLPDSSLR GFPSASAPPF GTDMDFSPPR
PPYPSFPHED PAYETPYLSE GFGYGMPPLY PQTGPPPSYR PGLRMFPETR GTTGCAQPPP
VSFLPRPFPS DPYGGRGSSF PLGLPFSPPA PFRPPLPASP PLEGPFPSQS DVHPLPAEGY
NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE GGCGTGGCEY ECVQEIAVHV
C
//
