ID A0A2I3MXK0_PAPAN Unreviewed; 2535 AA.
AC A0A2I3MXK0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Teneurin transmembrane protein 2 {ECO:0000313|Ensembl:ENSPANP00000040457.2};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSPANP00000040457.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000040457.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000040457.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000040457.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPANT00000057339.2; ENSPANP00000040457.2; ENSPANG00000009342.3.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000028761; Chromosome 5.
DR Bgee; ENSPANG00000009342; Expressed in visual cortex and 31 other cell types or tissues.
DR ExpressionAtlas; A0A2I3MXK0; baseline.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..184
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 404..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 470..503
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 574..609
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 45..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 493..502
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 578..588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 599..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2535 AA; 281465 MW; D009A86F14D85E82 CRC64;
MVSPPLLIIS VAGIIECKPD RLLWRPGSAS PQSVSFLHGK VVMESLGPPN HHSQSTLRPP
LPPPHNHTLS HHHSSANSLN RNSLTNRRSQ IHAPAPAPND LATTPESVQL QDSWVLNSNV
PLETRHFLFK TSSGSTPLFS SSSPGYPLTS GTVYTPPPRL LPRNTFSRKA FKLKKPSKYC
SWKCAALSAI AAALLLAILL AYFIVPWSLK NSSIDSGEAE VGRRVTQEVP PGVFWRSQIH
ISQPQFLKFN ISLGKDALFG VYIRRGLPPS HAQYDFMERL DGKEKWSVVE SPRERRSIQT
LVQNEAVFVQ YLDVGLWHLA FYNDGKDKEM VSFNTVVLDS VQDCPRNCHG NGECVSGVCH
CFPGFLGADC AKAACPVLCS GNGQYSKGTC QCYSGWKGAE CDVPMNQCID PSCGGHGSCI
DGNCVCSAGY KGEHCEEVDC LDPTCSSHGV CVNGECLCSP GWGGLNCELA RVQCPDQCSG
HGTYLPDTGL CSCDPNWMGP DCSVEVCSVD CGTHGVCIGG ACRCEEGWTG AACDQRVCHP
RCIEHGTCKD GKCECREGWN GEHCTIGRQT AGTETDGCPD LCNGNGRCTL GQNSWQCVCQ
TGWRGPGCNV AMETSCADNK DNEGDGLVDC LDPDCCLQSA CQNSLLCRGS RDPLDIIQQG
QTDWPAVKSF YDRIKLLAGK DSTHIIPGEN PFNSSLVSLI RGQVVTTDGT PLVGVNVSFV
KYPKYGYTIT RQDGTFDLIA NGGASLTLHF ERAPFMSQER TVWLPWNSFY AMDTLVMKTE
ENSIPSCDLS GFVRPDPIII SSPLSTFFSA APGQNPIVPE TQVLHEEIEL PGSTVKLRYL
SSRTAGYKSL LKITMTQSTV PLNLIRVHLM VAVEGHLFQK SFQASPNLAY TFIWDKTDAY
GQRVYGLSDA VVSVGFEYET CPSLILWEKR TALLQGFELD PSNLGGWSLD KHHILNVKSG
ILHKGTGENQ FLTQQPAIIT SIMGNGRRRS ISCPSCNGLA EGNKLLAPVA LAVGIDGSLY
VGDFNYIRRI FPSRNVTSIL ELRNNPAHKY YLAVDPVSGS LYVSDTNSRR IYRVKSLSGA
KDLAGNSEVV AGTGEQCLPF DEARCGDGGK AIDATLMSPR GIAVDKNGLM YFVDATMIRK
VDQNGIISTL LGSNDLTAVR PLSCDSSMDV AQVRLEWPTD LAVNPMDNSL YVLENNVILR
ITENHQVSII AGRPMHCQVP GIDYSLSKLA IHSALESASA IAISHTGVLY ITETDEKKIN
RLRQVTTNGE ICLLAGAASD CDCKNDVNCN CYSGDDAYAT DAILNSPSSL AVAPDGTIYI
ADLGNIRIRA VSKNKPVLNA FNQYEAASPG EQELYVFNAD GIHQYTVSLV TGEYLYNFTY
SADNDVTELI DNNGNSLKIR RDSSGMPRHL LMPDNQIITL TVGTNGGLKV VSTQNLELGL
MTYDGNTGLL ATKSDETGWT TFYDYDHEGR LTNVTRPTGV VTSLHREMEK SITIDIENSN
RDDDVTVITN LSSVEASYTV VQDQVRNSYQ LCNNGTLRVM YANGMGVSFH SEPHVLAGTI
TPTIGRCNIS LPMENGLNSI EWRLRKEQIK GKVTIFGRKL RVHGRNLLSI DYDRNIRTEK
IYDDHRKFTL RIIYDQVGRP FLWLPSSGLA AVNVSYFFNG RLAGLQRGAM SERTDIDKQG
RIVSRMFADG KVWSYSYLDK SMVLLLQSQR QYIFEYDSSD RLLAVTMPSV ARHSMSTHTS
IGYIRNIYNP PESNASVIFD YSDDGRILKT SFLGTGRQVF YKYGKLSKLS EIVYDSTAVT
FGYDETTGVL KMVNLQSGGF SCTIRYRKIG PLVDKQIYRF SEEGMVNARF DYTYHDNSFR
IASIKPVISE TPLPVDLYRY DEISGKVEHF GKFGVIYYDI NQIITTAVMT LSKHFDTHGR
IKEVQYEMFR SLMYWMTVQY DSMGRVIKRE LKLGPYANTT KYTYDYDGDG QLQSVAVNDR
PTWRYSYDLN GNLHLLNPGN SVRLMPLRYD LRDRITRLGD VQYKIDDDGY LCQRGSDIFE
YNSKGLLTRA YNKASGWSVQ YRYDGVGRRA SYKTNLGHHL QYFYSDLHNP TRITHVYNHS
NSEITSLYYD LQGHLFAMES SSGEEYYVAS DNTGTPLAVF SINGLMIKQL QYTAYGEIYY
DSNPDFQMVI GFHGGLYDPL TKLVHFTQRD YDVLAGRWTS PDYTMWKNVG KEPAPFNLYM
FKSNNPLSSE LDLKNYVTDV KSWLVMFGFQ LSNIIPGFPR AKMYFVPPPY ELSESQTSEN
GQLITGVQQT TERHNQAFMA LEGQVITKKL HASIREKAGH WFATTTPIIG KGIMFAIKEG
RVTTGVSSIA SEDSRKVASV LNNAYYLDKM HYSIEGKDTH YFVKIGSADG DLVTLGTTIG
RKVLESGVNV TVSQPTLLVN GRTRRFTNIE FQYSTLLLSI RYGLTPDTLD EEKARVLDQA
RQRALGTAWA KEQQKARDGR EGSRLWTEGE KQQLLSTGRV QGYEGYYVLP VEQYPELADS
SSNIQFLRQN EMGKR
//
