ID A0A2I3N4I4_PAPAN Unreviewed; 1912 AA.
AC A0A2I3N4I4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Protocadherin related 15 {ECO:0000313|Ensembl:ENSPANP00000042790.2};
GN Name=PCDH15 {ECO:0000313|Ensembl:ENSPANP00000042790.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000042790.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000042790.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000042790.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPANT00000032389.2; ENSPANP00000042790.2; ENSPANG00000022002.3.
DR GeneTree; ENSGT00940000156675; -.
DR Proteomes; UP000028761; Chromosome 11.
DR Bgee; ENSPANG00000022002; Expressed in retina and 38 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 9.
DR Gene3D; 2.60.40.3430; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR041149; EC_dom.
DR InterPro; IPR030718; EC_dom_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 7.
DR Pfam; PF18432; ECD; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 10.
DR SUPFAM; SSF49313; Cadherin-like; 10.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 9.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1912
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035216697"
FT TRANSMEM 1339..1362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 473..579
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 580..680
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 682..782
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 783..889
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 890..998
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1000..1107
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1108..1222
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1559..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1886..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1912 AA; 210825 MW; 8B126123FC7C3AD1 CRC64;
MFRQFYLWTC LASGIILGFL VEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM
LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC
INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID
DGPNGQIEYV IQYNPDDPDR AQNLNERRTT TTTLTVDVLD GDDLGPMFLP CVLVPNTRDC
RPLTYQAAIP ELRTPEELNP IVVTPPIQAI DQDRNIQPPS DRPGILYSIL VGTPEDYPRF
FHMHPRTAEL SLLEPVNRDF HQKFDLVIKA EQDNGHPLPA FASLHIEILD ENNQSPYFTM
PSYQGYILES APVGATIADS LNLTSPLRIV ALDKDIEDTK DPELHLFLND YTSVFTVTQT
GITRYLTLLQ PVDREEQQTY TFSITAFDGV QESEPVIVNI QVMDANDNTP TFPEISYDVY
VYTDMRPGDS VIQLTAVDAD EGSNGEITYE ILVGAQGDFI INKTTGLITI APGVEMIVGR
TYALTVQAAD NALPAERRHS ICTVYIEVLP PNNQSPPRFP QLMYSLEISE AMRVGAVLLN
LQATDREGDP ITYAIENGDP QRVFNLSETT GILTLGKALD RESTDRYILI ITASDGRPDG
TSTATVNVVV TDVNDNAPVF DPYLPRNLSV VEEEANAFVG QVKATDPDAG INGQVHYSLG
NFNNLFRITS NGSIYTAVKL NREVRDYYEL VVVATDGAVH PRHSTVTLAI KVLDIDDNSP
VFTNSTYTVL VEENLPAGTT ILQIEAKDVD LGANVSYRIR SPEVKHFFAL HPFTGELSLL
RSLDYEAFPD QEASITFLVE AFDIYGTMPP GIATVTVIVK DMNDYPPVFS KRIYKGMVAP
DAVKGTPITT VYAEDADPPG LPASRVRYRV DDVQFPYPAS IFDVEEDSGR VVTRVNLNEE
PTTIFKLVVV AFDDGEPVMS SSATVKILVL HPGEIPRFTQ EEYRPPPVSE LATKGTMVGV
ISAAAINQSI VYSIVSGNEE DTFGINNITG VIYVNGPLDY ETRTSYVLRV QADSLEVVLA
NLRVPSKSNT AKVYIEIQDE NNHPPVFQKK FYIGGVSEDA RMFTSVLRVK ATDKDTGNYS
VMAYRLIIPP IKEGKEGFVV ETYTGLIKTA MLFHNMRRSY FKFQVIATDD YGKGLSGKAD
VLVSVVNQLD MQVIVSNVPP TLVEKKIEDL TEILDRYVQE QIPGAKVVVE SIGARRHGDA
FSLEDYTKCD LTVYAIDPQT NRAIDRNELF KFLDGKLLDI NKDFQPYYGE GGRILEIRTP
EAVTSIKKRG ESLGYTEGAL LALAFIIILC CIPAILVVLV SYRQRQAECT KTARIQAALP
AAKPAAPAPA PVAAPPPPPP PPPGAHLYEE LGDSSILFLL CHFQQSRGNH SVSEDSKHQV
VMPFSSNTIE AHKAAHVDGS LKSNKPKSAR TFTFLSDEDA LSAHNPLYQE NISQVSTNSD
ISLRTDFVDP FLPKIQAKSK SLRGPREKIQ RLWSQSVSLP RRLMRKVPNR PEIIDLQQWQ
GPRQKAENEN TGICPNKRGS SSPLLTTEEA NLTEKEEIRQ GETLIIKGTE QLKSLSSDSS
FCFPRPHFSF STLPTVSRTV ELKSEPNVIT SPAECSLELS PSRPCVLNSS LSRRETPICM
LTVETERNIF ENFAHPPNIS PSACPPPPPP ISPPSPPPAP APLAPPPDIS PFSLFCPPPS
PPSIPLPLPP STFFPLSIST SGPPTPPLLP PFPTLPPPPP SIPCPPPPSA SFLSTECVCI
TGVKCTTNMM PAEEIKSSMT QLSATTVCKT DPRREPKGIL KHVKNLAELE KSVANMYSQI
EKNYLRTNVS ELQTMCPSEV TNMEITSEPN KENLNNIVEE TEKQSHSQST SL
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