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Database: UniProt
Entry: A0A2I3N619_PAPAN
LinkDB: A0A2I3N619_PAPAN
Original site: A0A2I3N619_PAPAN 
ID   A0A2I3N619_PAPAN        Unreviewed;      4933 AA.
AC   A0A2I3N619;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPANP00000043439};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPANP00000043439};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000043439, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000043439, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000043439}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AHZZ02017986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ02017987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000036285; ENSPANP00000043439; ENSPANG00000024680.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000028761; Chromosome 1.
DR   ExpressionAtlas; A0A2I3N619; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4255   4274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4475   4495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4549   4568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4676   4697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4734   4755       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4810   4833       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      589    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1015   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1327   1552       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3998   4033       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      462    482       {ECO:0000256|SAM:Coils}.
FT   COILED     3046   3066       {ECO:0000256|SAM:Coils}.
FT   COILED     3313   3333       {ECO:0000256|SAM:Coils}.
FT   COILED     4387   4420       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4933 AA;  560429 MW;  DCA46D940ABD9A8A CRC64;
     MLSDHSDSGE EDDEVVLQCT ATIHKEQQKL CLAAEGFGNR LCFLESTSNS KNVPPDLSIC
     TFVLEQSLSV RALQEMLANT VEKSEGQVDV EKWTAQGGGH RTLLYGHAIL LRHSYSGMYL
     CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER
     YLHLSYGNGS LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG
     EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV TTGKYLSLME
     DKNLLLMDKE KADVKSTAFT FRSSKEKLDV GVRKEVDGMG TSEIKYGDSV CYIQHVDTGL
     WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD DGISLSRSQH EESRTARVIR STVFLFNRFI
     RGLDALSKKA KASTVDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ
     EEGMINLVLE CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ
     FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL LDKHGRNHKV
     LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF LGVSEGSAQY
     KKWYYELMVD HTEPFVTAEA THLRVGWAST EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL
     HLWSGCIART VSSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP
     VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL
     LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL GWQYGPVRDD
     NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV GISDEHAEDK VKKMKLPKNY
     QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI QQDVKNRRNP
     RLVPYTLLDD RTKKSNKDSL REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA
     EKTYAVKAGR WYFEFETVTA GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE
     HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG FIPVCSLGVA
     QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW LSKRLPQFLQ VPSNHEHIEV
     TRIDGTIDSS PCLKVTQKSF GSQNSHTDIM FYRLSMPIEC AEVFSKTVAG GLPGAGLFGP
     KNDLEDYDAD SDFEVLMKTA HGHLVPDRVD KDKEATKPEF NNHKDYAQEK PSRLKQRFLL
     RRTKPDYSTS HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF
     HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR NNNGLEIGCV
     VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL
     FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL
     HIPEENRSVD ILELTEQEEL LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE
     NKYMPGLLRA GYYDLLIDIH LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG
     IGLSTSLRPR MQFSSPSFVS VSNECYQYSP EFPLDILKAK TIQMLTEAVK EGSLHARDPV
     GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK HILQLIEPSV FKEAATPEEE SDTLEKELSV
     DDAKLQGAGE EEAKGGKRPK EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD
     DFVAKLQDNQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE
     EIRDQLLDFH EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES
     DSKKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING
     VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET
     VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA
     SPAMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCQLL VSKGYPDIGW
     NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA
     IKIAEDPSRD GPSPNSGSSK TLDTEEEEDD TIHMGNAIMT FYAALIDLLG RCAPEMHLIH
     AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGN VVEPDMSAGF CPDHKAAMVL
     FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA SLDTVALSAT DMALALNRYL CTAVLPLLTR
     CAPLFAGTEH HASLIDSLLH TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR
     RLVFDVPLLN EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD
     ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN FNPQPVDTSN
     ITIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS SKVQPLMKPY KLLSEKEKEI
     YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQVSVDAAHG YSPRAIDMSN
     VTLSRDLHAM AEMMAENYHN IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ
     DILKFLQING YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK
     GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE KEMNIEKFSG
     QFIRHFVSSS GNDATSIVNC LHILGQTLDA RTVMKTGLES VKSALRAFLD NAAEDLEKTM
     ENLKQGQFTH TRNQPKGVTQ IINYTTVALL PMLSSLFEHI GQHQFGEDLI LEDVQVSCYR
     ILTSLYALGT SKSIYVERRR SQLKACQILL SFEVQNAIVA CGNLPYHLST FFEYNPFFMC
     TSPALSLPTN VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW
     EHGPENNPER AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV
     KPQLLKTHFL PLMEKLKKKA AMVVSEEDHL KAEARGDMSE AELLILDEFT TLARDLYAFY
     PLLIRFVDYN RAKWLKEPNP EAEELFRMVA EVFIYWSKSH NFKREEQNFV VQNEINNMSF
     LITDTKSKMS KAAVSDQERK KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA
     LAKNRFSLKD TEDEVRDIIR SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD TSDPEKTVER
     VLDIANVLFH LEQKSKRVGR RHYCLGSTVE HPQRSKKAVW HKLLSKQRKR AVVACFRMAP
     LYNLPRHRAV NLFLQGYEKS WIETEEHYFE DKLIEDLAKP GADPPEEDEG TKRVDPLHQL
     ILLFSRTALT EKCCHDEEDD DGEEEVKSFE EKEMEKQKLL YQQARLHDRG AAEMVLQTIS
     ASKGETGPMV AATLKLGIAI LNGGNSTVQQ KMLDYLKEKK DVGFFQSLAG LMQSCSVLDL
     NAFERQNKAE GLGMVTEEGS GEKVLQDDEF TCDLFRFLQL LCEGHNSDFQ NYLRTQTGNN
     TTVNIIISTV DYLLRVQESI SDFYWYYSGK DVIDEQGQRN FSKAIQVAKQ VFNTLTEYIQ
     GPCTGNQQSL AHSRLWDAVV GFLHVFAHMQ MKLSQDSSQI ELLKELMDLQ KDMVVMLLSM
     LEGNVVNGTI GKQMVDMLVE SSNNVEMILK FFDMFLKLKD LTSSDTFKEY DPDGKGVISK
     RDFHKAMESH KHYTQSETEF LLSCAETDEN ETLDYEEFVK RFHEPAKDIG FNVAVLLTNL
     SEHMPNDTRL QTFLELAESV LNYFQPFLGR IEIMGSAKRI ERVYFEISES SRTQWEKPQV
     KESKRQFIFD VVNEGGEKEK MELFVNFCED TIFEMQLAAQ ISESDLNERS ANKEDSEKER
     PEEQGPRMAF FSILTVKSAL FALRYNILTL MRMLSLKSLK KQMKKVKKMT VKDMVTAFFS
     SYWSIFMTLL HFVASVFRGF FRIICSLLLG GSLVEGAKKI KVAELLANMP DPTQDEVRGD
     GEEGERKTLE AALPSEDLTD LKELTEESDL LSDIFGLDLK REGGQYKLIP HNPNAGLSDL
     MSNPVPMPEV QEKFQEQKAK EEEKEEKEET KSEPEKAEGE DGEKEEKAKE DKGKQKLRQL
     HTHRYGEPEV PESAFWKKII AYQQKLLNYF ARNFYNMRML ALFVAFAINF ILLFYKVSTS
     SVVEGKELPT RSSSENAKVT SLDSGSHRII AVHYVLEESS GYMEPTLRIL AILHTVISFF
     CIIGYYCLKV PLVIFKREKE VARKLEFDGL YITEQPSEDD IKGQWDRLPT KCFFSYPKVM
     DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF
     TDNSFLYLAW YMTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL
     AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP
     AGDEYEIYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG
     NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA
     GDCFRKQYED QLN
//
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