ID A0A2I3RA22_PANTR Unreviewed; 1294 AA.
AC A0A2I3RA22;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSPTRP00000061472.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSPTRP00000061472.1,
GN ECO:0000313|VGNC:VGNC:7728};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000061472.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000061472.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000061472.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AACZ04043747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04043748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04043749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC192137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000110052.1; ENSPTRP00000061472.1; ENSPTRG00000015875.6.
DR VGNC; VGNC:7728; EVC2.
DR GeneTree; ENSGT00940000154127; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000015875; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 35..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 449..476
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 993..1027
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1294 AA; 146482 MW; A4B1B39ADD190291 CRC64;
MDPSGSRGRP TWVLAGGLLA VALALGGRGC LGASSRPRWR PLGAQPPRDP QVAPRSGPGL
RTPPGRSGAG PESSTQDLPC MIWPKVECCH FKTAVEAPLG MKLDKKMEVF IPLSTSAASS
GPWAHSLFAF IPSWPKKNLF KRESPITYRL FNTLTQIPEV SESSEAQTAR IWLLVNNTKT
TSSANLSELL LLDSIAGLTI WDSIGNRTSE GFQAFSKKFL QVGDAFAVSY AATLQAGDLG
NGESLKLPAQ LTFQSSSRNR TQLKALFSIT AEENITVLPH HGLHAAGFFI AFLLSLVLTW
AALFLMVRYQ CLKGNMLTRH RVWQYESKLE PLPFTSADGV NEDLSLNDQM IDILSSEDPG
SMLQALEELE IATLNRADAD LEACRTQISK DIIALLLKSL TSSGHLSPQV ERKMSAVFKK
QFLLLESEIQ EEYDRKMVAL TAECDLETRK KMENQYQREM MAMEEAEELL KRASERSAVE
CSNLLRTLHG LEQEHLRKSL ALQQEEDFAK AHRQLAVFQR NELHSIFFTQ IKSAIFKGEL
KPEAAKTLLQ NYSKIQENVE ELMDFFQASK RYHLSKRFGH REYLVQNLQS SETRVQGLLS
TAAAQLTHLI QKHERAGYLD EDQMEVLLER AQTEVFSIKQ KLDNDLKQEK KKLHQKLITK
RRRELLQKHR EQRREQVSVS EAFRAVEDAG QYLHQRRSLM EEHGAALEEL QERLDQAALD
DLRTLTLSLF EKATDELRRL QNSAMTQELL KRGVPWLFLQ QILEEHGKEM AARAEQLEGE
ERDRDQEGVQ SVRQRLKDDA PEAVTEEQAE LRRWEHLIFM KLSSSVFSLS EEELLRMRQE
VHGCFAQMDR SLALPKIRSR VLLQQFQTAW REAEFVKLDQ AMAAPELQQQ SKVRKSRSKS
KSKGELLKKC IEDKIHLCEE QASEDLVEKV RGELLRERVQ RMEAQEGGFA QSLVALQFQK
ASRVTETLSA YTALLSIQDL LLEELSASEM LTKSACTQIL ESHSRELQEL ERKLEDQLVQ
QEAAQQQQAL ASWQQWVADG PGILNEPGEV DSERQVSTVL QQALSKSQTL LEQHQQCLRE
EQQNSVVLED LLENMEADTF ATLCSQELRL ASYLARMAMV PGATLRRLLS VVLPTASQPQ
LLALLDSATE RHADHAAESD GGAEQADVGR RRKHQSWWQA LDGKLRGDLI SRGLEKMLWA
RKRKQSILKK TCLPLRERMI FSGKGSWPHL SLEPIGELAP VPIVGAETID LLNTGEKLLI
FRNPKEPEIS LHVPPRKKKN FLNAKKAMRA LGMD
//