ID A0A2I3RDJ2_PANTR Unreviewed; 349 AA.
AC A0A2I3RDJ2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin light chain kinase {ECO:0000313|Ensembl:ENSPTRP00000062707.1};
GN Name=MYLK {ECO:0000313|Ensembl:ENSPTRP00000062707.1,
GN ECO:0000313|VGNC:VGNC:2433};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000062707.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000062707.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000062707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; AACZ04048122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04048123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RDJ2; -.
DR Ensembl; ENSPTRT00000094061.1; ENSPTRP00000062707.1; ENSPTRG00000015307.7.
DR VGNC; VGNC:2433; MYLK.
DR GeneTree; ENSGT00940000157879; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015307; Expressed in colon and 21 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd05762; IgI_8_hMLCK_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR PANTHER; PTHR47633:SF9; MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE-RELATED; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 47..135
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 143..235
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 273..349
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 302
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 349 AA; 39270 MW; B78A633283A72E46 CRC64;
MQADPCSGED APASENTKAP EMKSRRPKSS LPPVLGTESE YSPTMPPQII QFPEDQKVRA
GESVELFGKV TGTQPITCTW MKFRKQIQES EHMKVENSEN GSKLTILAAR QEHCGCYTLL
VENKLGSRQA QVNLTVVDKP DPPAGTPCAS DIRSSSLTLS WYGSSYDGGS AVQSYSIEIW
DSANKTWKEL ATCRSTSFNV QDLLPDHEYK FRVRAINVYG TSEPSQESEL TTVGEKPEEP
KDEVEVSDDD EKEPEVDYRT VTINTEQKVS DFYDIEERLG SGKFGQVFRL VEKKTRKVWA
GKFFKAYSAK EKENIRQEIS IMNCLHHPKL VQCVDAFEEK ANIVMVLEM
//
