ID A0A2I3REG2_PANTR Unreviewed; 1077 AA.
AC A0A2I3REG2; A0A2J8NXU2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN Name=BAG6 {ECO:0000313|Ensembl:ENSPTRP00000063021.1,
GN ECO:0000313|VGNC:VGNC:58877};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000063021.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000063021.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000063021.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC natural killer/NK cells receptor NCR3 and stimulates NK cells
CC cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC neighboring tumor cells and immature myeloid dendritic cells (DC).
CC {ECO:0000256|ARBA:ARBA00002067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04022799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016810646.1; XM_016955157.1.
DR RefSeq; XP_016810647.1; XM_016955158.1.
DR AlphaFoldDB; A0A2I3REG2; -.
DR Ensembl; ENSPTRT00000109697.1; ENSPTRP00000063021.1; ENSPTRG00000051839.1.
DR GeneID; 462560; -.
DR CTD; 7917; -.
DR VGNC; VGNC:58877; BAG6.
DR GeneTree; ENSGT00390000016199; -.
DR OMA; NRITVAM; -.
DR OrthoDB; 3177594at2759; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000051839; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 17..77
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 87..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..205
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..677
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 113420 MW; 4A417E0EA49A5E33 CRC64;
MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI
YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGPPPGTRGP
GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL
SRMECRGGPQ PQHSQPPPQP PAVTPEPVAL SSQTSEPVES EAPPREPMEA EEVEERAPAQ
NPELTPGPAP AGPTPAPETN APNHPSPAEY VEVLQELQRL ESRLQPFLQR YYEVLGAAAT
TDYNNNHEGR EEDQRLINLV GESLRLLGNT FVALSDLRCN LACTPPRHLH VVRPMSHYTT
PMVLQQAAIP IQINVGTTVT MTGNGTRPPP TPNAEAPPPG PGQASSVAPS STNVESSAEG
APPPGPAPPP ATSHPRVIRI SHQSVEPVVM MHMNIQDSGT QPGGVPSAPT GPLGPPGHGQ
TLGQQVPGFP TAPTRVVIAR PTPPQARPSH PGGPPVSGTL QGAGLGTNAS LAQMVSGLVG
QLLMQPVLVA QGTPGMAPPA APATASASAG TTNTATTAGP APGGPAQPPP APQPSTADLQ
FSQLLGNLLG PAGPGAGGPG VASPTITVAM PGVPAFLQGM TDFLQATQTA PPPPPPPPPP
PPAPEQQTMP PPGSPSGGAG SPGGLGLESL SPEFFTSVVQ GVLSSLLGSL GARAGSSESI
AAFIQRLSGS SNIFEPGTDG ALGFFGALLS LLCQNFSMVD VVMLLHGHFQ PLQRLQPQLR
SFFHQHYLGG QEPTPSNIRM ATHTLITGLE EYVRESFSLV QVQPGVDIIR TNLEFLQEQF
NSIAAHVLHC TDSGFGARLL ELCNQGLFEC LALNLHCLGG QQMELAAVIN GRIRRMSRGV
NPSLVSWLTT MMGLRLQVVL EHMPVGPDAI LRYVRRVGDP PQPLPEEPME VQGAERASPE
PQRENASPAP GTTAEEAMSR GPPPAPEGGS RDEQDGASAE TEPWAAAVPP EWVPIIQQDI
QSQRKVKPQP PLSDAYLSGM PAKRRKLRSD IQKRLQEDPN YSPQRFPNAQ RAFADDP
//
