ID A0A2I3RER2_PANTR Unreviewed; 377 AA.
AC A0A2I3RER2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Nucleoredoxin {ECO:0000256|ARBA:ARBA00026178};
DE EC=1.8.1.8 {ECO:0000256|ARBA:ARBA00012612};
GN Name=NXN {ECO:0000313|Ensembl:ENSPTRP00000062877.1,
GN ECO:0000313|VGNC:VGNC:12578};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000062877.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000062877.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000062877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) +
CC NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000696};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) +
CC NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001346};
CC -!- SIMILARITY: Belongs to the nucleoredoxin family.
CC {ECO:0000256|ARBA:ARBA00025782}.
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DR EMBL; AACZ04062745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04062752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RER2; -.
DR Ensembl; ENSPTRT00000088876.1; ENSPTRP00000062877.1; ENSPTRG00000008513.6.
DR VGNC; VGNC:12578; NXN.
DR GeneTree; ENSGT00940000161894; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008513; Expressed in colon and 20 other cell types or tissues.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase (NADP) activity; IEA:InterPro.
DR CDD; cd03071; PDI_b'_NRX; 1.
DR CDD; cd03009; TryX_like_TryX_NRX; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR041861; NRX_PDI_b.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR045870; TryX_NRX_thioredoxin_dom.
DR PANTHER; PTHR46472; NUCLEOREDOXIN; 1.
DR PANTHER; PTHR46472:SF1; NUCLEOREDOXIN; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..377
FT /note="Nucleoredoxin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014121437"
FT DOMAIN 109..263
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 377 AA; 42371 MW; 9966D9515B98A64B CRC64;
LFPLLLPFSC LLGCDTSLPC SAQGRSLPAG TLKPPAGRLR AERPKQWGTL QLPCLCLFWR
NTLKLWNKYR ISNIPSLIFL DATTGKVVCR NGLLVIRDDP EGLEFPWGPK PFREVIAGPL
LRNNGQSLES SSLEGSHVGV YFSAHWCPPC RSLTRVLVES YRKIKEAGQN FEIIFVSADR
SEESFKQYFS EMPWLAVPYT DEARRSRLNR LYGIQGIPTL IMLDPQGEVI TRQGRVEVLN
DEDCREFPWH PKPVLELSDS NAAQLNEGPC LVLFVDSEDD GESEAAKQLI QPIAEKIIAK
YKAKEEEAPL LFFVAGEDDM TDSLRDYTNL PEAAPLLTIL DMSARAKYVM DVEEITPAIV
EAFVNDFLAE KLKPEPI
//
