ID A0A2I3REY3_PANTR Unreviewed; 2400 AA.
AC A0A2I3REY3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Neuron navigator 2 {ECO:0000313|Ensembl:ENSPTRP00000063240.1};
GN Name=NAV2 {ECO:0000313|Ensembl:ENSPTRP00000063240.1,
GN ECO:0000313|VGNC:VGNC:3097};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000063240.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000063240.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000063240.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR EMBL; AACZ04016556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000101827.1; ENSPTRP00000063240.1; ENSPTRG00000003436.6.
DR VGNC; VGNC:3097; NAV2.
DR GeneTree; ENSGT00940000155663; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003436; Expressed in colon and 21 other cell types or tissues.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR CDD; cd21285; CH_NAV2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF6; NEURON NAVIGATOR 2; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 77..184
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 186..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1546..1601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2400 AA; 258691 MW; E7E44D46A65465CB CRC64;
SQSQTEYLKW EVFAPGVVHQ PVICESQHFA SPRPGLGGRI LCSMSSTSLG SRAESRLYQG
EEGEEGEGIN NELVACLLFL QIYTDWANHY LAKSGHKRLI KDLQQDVTDG VLLAQIIQVV
ANEKIEDING CPKNRSQMIE NIDACLNFLA AKGINIQGLS AEEIRNGNLK AILGLFFSLS
RFKQQQQQPQ KQHLSSPLPP AVSQVAGAPS QCQAGTPQQQ VPVTPQAPCQ PHQPAPHQQS
KAQAEMQSRL PGPTARVSAA GSEAKTRGGS TTANNRRSQS FNNYDKSKPV TSPPPPPSSH
EKEPLASSAS SHPGMSDNAP ASLESGSSST PTNCSTSSAI PQPGAATKPW RSKSLSVKHS
ATVSMLSVKP PGPEAPRPTP EAMKPAPNNQ KSMLEKLKLF NSKGGSKAGE GPGSRDTSCE
RLETLPSFEE SEELEAASRM LTTVGPASSS PKIALKGIAQ RTFSRALTNK KSSLKGNEKE
KEKQQREKDK EKSKDLAKRA SVTERLDLKE EPKEDPSGAA VPEMPKKSSK IASFIPKGGK
LNSAKKEPMA PSHSGIPKPG MKSMPGKSPS APAPSKEGER SRSGKLSSGL PQQKPQLDGR
HSSSSSSLAS SEGKGPGGTT LNHSISSQTV SGSVGTTQTT GSNTVSVQLP QPQQQYNHPN
TATVAPFLYR SQTDTEGNVT AESSSTGVSM EPSHFTKTGQ PALEELTGED PEARRLRTVK
NIADLRQNLE ETMSSLRGTQ VTHSTLETTF DTNVTTEMSG RSILSLTGRP TPLSWRLGQS
SPRLQAGDAP SMGNGYPPRA NASRFINTES GRYVYSAPLR RQLASRGSSV CHVDVSDKAG
DEMDLEGISL DAPGYMSDGD VLSKNIRTDD ITSGYMTDGG LGLYTRRLNR LPDGMAVVRE
TLQRNTSLDA EVIPGCSVSS GISDTIDNLS TDDINTSSSI SSYANTPASS RKNLDVQTDA
EKHSQVERNS LWSGDDVKKS DGGSDSGIKM EPGSKWRRNP SDVSDESDKS TSGKKNPVIS
QTGSWRRGMT AQVGITMPRT KPSAPAGALK TPGTGKTDDA KVSEKGRLSP KASQVKRSPS
DAGRSSGDES KKPLPSSSRT PTANANSFGF KKQSGSAAGL AMITASGVTV TSRSATLGKI
PKSSALVSRS AGRKSSMDGA QNQDDGYLAL SSRTNLQYRS LPRPSKSNSR NGAGNRSSTS
SIDSNISSKS AGLPVPKLRE PSKTALGSSL PGLVNQTDKE KGISSDNESV ASCNSVKVNP
AAQPVSSPAQ TSLQPGAKYP DVASPTLRRL FGGKPTKQVP IATAENMKNS VVISNPHATM
TQQGNLDSPS GSGVLSSGSS SPLYSKNVDL NQSPLASSPS SAHSAPSNSL TWGTNASSSS
AVSKDGLGFQ SISSLHTSCE SIDISLSSGG VPSHNSSTGL IASSKDDSLT PFVRTNSVKT
TLSESPLSSP AASPKFCRST LPRKQDRPGT NRASRYTPTS QLRTQEDAKE WLRSHSAGGL
QDTAANSPFS SGSSVTSPSG TRFNFSQLAS PTTVTQMSLS NPTMLRTHSL SNADGQYDPY
TDSRFRNSSM SLDEKSRTMS RSGSFRDGFE EGKEGKEEEE KCQSEIRKLR RELDASQEKV
SALTTQLTAN AHLVAAFEQS LGNMTIRLQS LTMTAEQKDS ELNELRKTIE LLKKQNAAAQ
AAINGVINTP ELNCKGNGTA QSADLRIRRQ HSSDSVSSIN SATSHSSVGS NIESDSKKKK
RKNWVSLRSS FKQAFGKKKS PKSASSHSDI EEMTDSSLPS SPKLPHNGST GSTPLLRNSH
SNSLISECMD SEAETVMQLR NELRDKEMKL TDIRLEALSS AHQLDQLREA MNRMQSEIEK
LKAENDRLKS ESQGSGCSRA PSQVSISASP RQSMGLSQHS LNLTESTSLD MLLDDTGECS
ARKEGGRHVK IVVSFQEEMK WKEDSRPHLF LIGCIGVSGK TKWDVLDGVV RRLFKEYIIH
VDPVSQLGLN SDSVLGYSIG EIKRSNTSET PELLPCGYLV GENTTISVTV KGLAENSLDS
LVFESLIPKP ILQRYVSLLI EHRRIILSGP SGTGKTYLAN RLSEYIVLRE GRELTDGVIA
TFNVDHKSSK ELRQYLSNLA DQCNSENNAV DMPLVIILDN LHHVSSLGEI FNGLLNCKYH
KCPYIIGTMN QATSSTPNLQ LHHNFRWVLC ANHTEPVKGF LGRFLRRKLM ETEISGRVRN
MELVKIIDWI PKVWHHLNRF LEAHSSSDVT IGPRLFLSCP IDVDGSRVWF TDLWNYSIIP
YLLEAVREGL QLYGRRAPWE DPAKWVMDTY PWAASPQQHE WPPLLQLRPE DVGFDGYSMP
REGSTSKQMP PSDAEGDPLM NMLMRLQEAA NYSSPQSYDS DSNSNSHHDD ILDSSLESTL
//
