ID A0A2I3RF69_PANTR Unreviewed; 485 AA.
AC A0A2I3RF69; A0A2J8J0Y2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Polynucleotide kinase 3'-phosphatase {ECO:0000313|Ensembl:ENSPTRP00000063283.1};
GN Name=PNKP {ECO:0000313|Ensembl:ENSPTRP00000063283.1,
GN ECO:0000313|VGNC:VGNC:2440};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000063283.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000063283.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000063283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04055865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RF69; -.
DR Ensembl; ENSPTRT00000081459.1; ENSPTRP00000063283.1; ENSPTRG00000011323.5.
DR VGNC; VGNC:2440; PNKP.
DR GeneTree; ENSGT00940000159302; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000011323; Expressed in lymph node and 20 other cell types or tissues.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd22736; FHA_PNKP; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041388; FHA_2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013954; PNK3P.
DR InterPro; IPR006550; PNKP.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF17913; FHA_2; 1.
DR Pfam; PF08645; PNK3P; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 11..80
FT /note="PNK FHA"
FT /evidence="ECO:0000259|Pfam:PF17913"
FT REGION 109..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53074 MW; FD4145D199F343AC CRC64;
MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP
GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR
SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKVLVATHAG LYRKPVTGMW DHLQEQANDG
APISIGDSIF VGDAAGRPAN WAPGRKKKDF SCADRLFALN LGLPFATPEE FFLKWPAAGF
ELPAFDPRTV SRSGPLCLPE SRALLSASPE VVVAVGFPGA GKSTFLKKHL VSAGYVHVNR
DTLGSWQRCV TTCETALKQG KRVAIDNTNP DAASRARYVQ CARAAGVPCR CFLFTATLEQ
ARHNNRFREM TDSSHIPVSD MVMYGYRKQF EAPTPAEGFS AILEIPFRLW VEPRLGRLYC
QFSEG
//
