ID A0A2I3RFI8_PANTR Unreviewed; 1052 AA.
AC A0A2I3RFI8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Serine peptidase inhibitor Kazal type 5 {ECO:0000313|Ensembl:ENSPTRP00000063455.1};
GN Name=SPINK5 {ECO:0000313|Ensembl:ENSPTRP00000063455.1,
GN ECO:0000313|VGNC:VGNC:57616};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000063455.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000063455.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000063455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04059130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RFI8; -.
DR Ensembl; ENSPTRT00000101132.1; ENSPTRP00000063455.1; ENSPTRG00000043281.1.
DR VGNC; VGNC:57616; SPINK5.
DR GeneTree; ENSGT00510000048608; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000043281; Expressed in hindlimb stylopod muscle and 6 other cell types or tissues.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd01327; KAZAL_PSTI; 2.
DR Gene3D; 3.30.60.30; -; 15.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR47499; SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7; 1.
DR PANTHER; PTHR47499:SF2; SERINE PROTEASE INHIBITOR KAZAL-TYPE 9; 1.
DR Pfam; PF00050; Kazal_1; 10.
DR SMART; SM00280; KAZAL; 14.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 15.
DR PROSITE; PS00282; KAZAL_1; 2.
DR PROSITE; PS51465; KAZAL_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1052
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014138171"
FT DOMAIN 96..158
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 755..817
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 974..1035
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 738..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 119889 MW; CF5D4AB8BA0B0B5F CRC64;
MDYLFCLLNI LHFLNFGFYI FIPDAASKNE DQEICHEFQA FMKNGKLLCP QDKKFFQSLD
GIMFINKCAT CKMILEKEAK SQKRARHLAR AAKATAPTEL NCDDFKKGER DGDFICPDFY
EAVCGTDGKT YDNRCALCAE NAKTGSQIGV KSEGECKSSN PEQDVCSAFR PFVKDGRLGC
TRENDPVLGP DGKTHGNKCA MCAELFLKEA ENAKREGETR IRRNAEKDFC KEYEKQVRNG
RLFCTRESDP VRGPDGRMHG NKCALCAEIF KRRFSEENSK TDQNLGKAEE KTKVKREIVK
LCSQYQNQAK NGILFCTREN DPIRGPDGKM HGNLCSMCQA YFQAENEEKK KPEAQARNKR
ESGKATSYAE LCSEYRKLVR NGKLACTREN DPIQGPDGKV HGNTCSMCEV FFQAEEEEKK
KKEGESRNKR QSKSTASFEE LCSEYRKSRK NGRLFCTREN DPIQGPDGKM HGNTCSMCEA
FFQQEERARA KAKREAAKEI CSEFRDQVRN GTLICTREHN PVRGPDGKMH GNKCAMCASV
FKLEEEEKKN NKEEKGKVEA EKVKREAVQE LCSEYRHYVR NGRLPCTREN DPIEGLDGKI
HGNTCSMCEA FFQQEAKEKE RAEPRAKVKR EAEKETCDEF RSLLQNGKLF CTRENDPVRG
PDGKTHGNKC AMLHKENHYL IQGLFILLCF QDECAEYREQ MENGRLSCTR ESDPVRDADG
KSYNNQCTMC KAKLEREAER KNEYSRSRSN GTGSESGKDT CDEFRSQMKN GKLICTRESD
PVRGPDGKTH GNKCTMCKEK LEREAAEKKK KEDEDRSNTG ERSNTGERSN DKEDLCREFR
SMQRNGKLIC TRENNPVRGP YGKMHINKCA MCQSIFDREA NERKKKDEEK SSSKPSNNAK
DECSEFRNYI RNNELICPRE NDPVHGADGK FYTNKCYMCR AVFLTEALER AKLQEKPSHV
RASQEEDSPD SFSSLDSEMC KDYRVLPRIG YLCPKDLKPV CGDDGQTYNN PCMLCHENLI
RQTNTHIRSI GKCEESSTPG TTAASMPLSV ST
//
