ID A0A2I3RFX4_PANTR Unreviewed; 234 AA.
AC A0A2I3RFX4; A0A2J8LNG2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Synaptogyrin {ECO:0000256|PIRNR:PIRNR011282};
GN Name=SYNGR1 {ECO:0000313|Ensembl:ENSPTRP00000063596.1,
GN ECO:0000313|VGNC:VGNC:12929};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000063596.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000063596.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paabo S., Reinhardt R., Zheng H.-J., Zhang X.-L., Zhu G.-F.,
RA Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E.,
RA Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G.,
RA Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S., Wang S.-Y.,
RA Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000063596.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000063596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|PIRNR:PIRNR011282}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|PIRNR:PIRNR011282}.
CC -!- SIMILARITY: Belongs to the synaptogyrin family.
CC {ECO:0000256|ARBA:ARBA00010252, ECO:0000256|PIRNR:PIRNR011282}.
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DR EMBL; AACZ04068034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009436587.2; XM_009438312.2.
DR AlphaFoldDB; A0A2I3RFX4; -.
DR STRING; 9598.ENSPTRP00000063596; -.
DR PaxDb; 9598-ENSPTRP00000024797; -.
DR Ensembl; ENSPTRT00000109939.1; ENSPTRP00000063596.1; ENSPTRG00000041182.2.
DR GeneID; 100192454; -.
DR CTD; 9145; -.
DR VGNC; VGNC:12929; SYNGR1.
DR GeneTree; ENSGT00950000182935; -.
DR InParanoid; A0A2I3RFX4; -.
DR OMA; FYLWSQW; -.
DR OrthoDB; 4177492at2759; -.
DR Proteomes; UP000002277; Chromosome 22.
DR Bgee; ENSPTRG00000041182; Expressed in dorsolateral prefrontal cortex and 20 other cell types or tissues.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR016579; Synaptogyrin.
DR PANTHER; PTHR10838; SYNAPTOGYRIN; 1.
DR PANTHER; PTHR10838:SF7; SYNAPTOGYRIN-1; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PIRSF; PIRSF011282; Synaptogyrin; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR011282, ECO:0000256|PROSITE-
KW ProRule:PRU00581}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR011282, ECO:0000256|PROSITE-
KW ProRule:PRU00581}; Transmembrane helix {ECO:0000256|PIRNR:PIRNR011282}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 69..92
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 104..128
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT DOMAIN 20..173
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT REGION 195..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 234 AA; 25540 MW; 8B015CBEBD561F12 CRC64;
MEGGAYGAGK AGGAFDPYTL VRQPHTILRV VSWLFSIVVF GSIVNEGYLN SASEGEEFCI
YNRNPNACSY GVAVGVLAFL TCLLYLALDV YFPQISSVKD RKKAVLSDIG VSAFWAFLWF
VGFCYLANQW QVSKPKDNPL NEGTDAARAA IAFSFFSIFT WAGQAVLAFQ RYQIGADSAL
FSQDYMDPSQ DSSMPYAPYV EPNTGPDPAG MGGTYQQPAN AFDTEPQGYQ SQGY
//
