ID A0A2I3RI42_PANTR Unreviewed; 323 AA.
AC A0A2I3RI42; A0A2J8MYX9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN Name=GPN3 {ECO:0000313|Ensembl:ENSPTRP00000064347.1,
GN ECO:0000313|VGNC:VGNC:5406};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000064347.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000064347.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000064347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|ARBA:ARBA00002411}.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; AACZ04070355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_509364.2; XM_509364.5.
DR AlphaFoldDB; A0A2I3RI42; -.
DR STRING; 9598.ENSPTRP00000064347; -.
DR Ensembl; ENSPTRT00000091478.1; ENSPTRP00000064347.1; ENSPTRG00000005440.4.
DR GeneID; 452233; -.
DR CTD; 51184; -.
DR VGNC; VGNC:5406; GPN3.
DR GeneTree; ENSGT00950000183172; -.
DR InParanoid; A0A2I3RI42; -.
DR OrthoDB; 168004at2759; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000005440; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 37461 MW; CD2B3862A5A82897 CRC64;
MLPKTRGAFH FSIPDPQHIR KSRGSPYRSN VCTQTTDRST RRKDAELYLL SVITQSTYCA
TMVQHCEALN RSVQVVNLDP AAEHFNYSVM ADIRELIEVD DVMEDDSLRF GPNGGLVFCM
EYFANNFDWL ENCLGHVEDD YILFDCPGQI ELYTHLPVMK QLVQQLEQWE FRVCGVFLVD
SQFMVESFKF ISGILAALSA MISLEIPQVN IMTKMDLLSK KAKKEIEKFL DPDMYSLLED
STSDLRSKKF KKLTKAICGL IDDYSMVRFL PYDQSDEESM NIVLQHIDFA IQYGEDLEFK
EPKEREDESS SMFDEYFQEC QDE
//
