ID A0A2I3RJV4_PANTR Unreviewed; 852 AA.
AC A0A2I3RJV4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Notch receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000064948.1};
GN Name=NOTCH2 {ECO:0000313|Ensembl:ENSPTRP00000064948.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000064948.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000064948.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000064948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AACZ04034398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC185244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RJV4; -.
DR Ensembl; ENSPTRT00000106136.1; ENSPTRP00000064948.1; ENSPTRG00000048364.1.
DR GeneTree; ENSGT00940000155030; -.
DR OMA; FTGQTCG; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000048364; Expressed in lymph node and 21 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24033:SF226; DELTA-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 12.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 5.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 14.
DR PROSITE; PS00022; EGF_1; 18.
DR PROSITE; PS01186; EGF_2; 15.
DR PROSITE; PS50026; EGF_3; 20.
DR PROSITE; PS01187; EGF_CA; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 14..52
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 55..93
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 94..130
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 132..169
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 171..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 210..246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 248..286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 288..324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 365..404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 520..555
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 557..593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 595..630
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 632..668
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 670..705
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 707..743
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 745..778
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 23..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 42..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 83..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 120..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 159..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 236..245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 276..285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 314..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 334..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 353..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 394..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 470..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 524..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 545..554
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 583..592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 599..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 620..629
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 658..667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 674..684
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 695..704
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 733..742
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 852 AA; 91403 MW; 9F26F7837D2D30C7 CRC64;
TVCPEGFLGE YCQHRDPCEK NRCQNGGTCV AQAMLGKAMC RCASGFTGED CQYSTSHPCF
VSRPCLNGGT CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HPCANGSTCT TVANQFSCKC
LTGFTGQKCE TDVNECDIPG HCQHGGTCLN LPGSYQCQCP QGFTGQYCDS LYVPCAPSPC
VNGGTCRQTG DFTFECNCLP GFEGSTCERN IDDCPNHRCQ NGGVCVDGVN TYNCRCPPQW
TGQFCTEDVD ECLLQPNACQ NGGTCANRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG
STCIDRVASF SCMCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI CTCPQGYKGA
DCTEDVDECS MANSNPCEHA GKCVNTDGAF HCECLKGYAG PRCEMDINEC HSDPCQNDAT
CLDKIGGFTC LCMPGFKGVH CELEINECQS NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ
IDIDDCSSTP CLNGAKCIDH PNGYECQCAT GFTGVLCEEN IDNCDPDPCH HGQCQDGIDS
YTCICNPGYM GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGV NCEINFDDCA
SNPCIHGNCM DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKGATCING VNGFRCICPE
GPHHPSCYSQ VNECLSNPCI HGNCTGGLSG YKCLCDAGWV GINCEVDKNE CLSNPCQNGG
TCDNLVNGYR CTCKKGFKGY NCQVNIDECA SNPCLNQGTC FDDISGYTCH CVLPYTGGSW
RYQQGPEGIL DLALSVPESQ CPGLWGCNAP PRAHSSVVLP AFTDWILSFE ETLWHPKMQV
VDSHLPTLYF SI
//
