ID A0A2I3RKH6_PANTR Unreviewed; 306 AA.
AC A0A2I3RKH6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Citramalyl-CoA lyase {ECO:0000313|Ensembl:ENSPTRP00000065189.1};
GN Name=CLYBL {ECO:0000313|Ensembl:ENSPTRP00000065189.1,
GN ECO:0000313|VGNC:VGNC:13073};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000065189.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000065189.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000065189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AACZ04072699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04072700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RKH6; -.
DR Ensembl; ENSPTRT00000087917.1; ENSPTRP00000065189.1; ENSPTRG00000005998.6.
DR VGNC; VGNC:13073; CLYBL.
DR GeneTree; ENSGT00390000017163; -.
DR Proteomes; UP000002277; Chromosome 13.
DR Bgee; ENSPTRG00000005998; Expressed in liver and 20 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 2.
DR InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR InterPro; IPR040186; Citramalyl-CoA_lyase.
DR InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF03328; HpcH_HpaI; 2.
DR PIRSF; PIRSF015582; Cit_lyase_B; 2.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 46..147
FT /note="HpcH/HpaI aldolase/citrate lyase"
FT /evidence="ECO:0000259|Pfam:PF03328"
FT DOMAIN 163..240
FT /note="HpcH/HpaI aldolase/citrate lyase"
FT /evidence="ECO:0000259|Pfam:PF03328"
FT BINDING 172
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
SQ SEQUENCE 306 AA; 33429 MW; 4D1D74D6F425C6C0 CRC64;
MALRLLRRAA RGAAAAALLR LKASLAADIP RLGYSSSSHH KYIPRRAVLY VPGNDEKKIK
KIPSLNVDCA VLDCEDGVAA NKKNEARLRI VKTLEDFDLG PTEKCVRVNS VSSGLAEEDL
ETLLQSRVLP SSLMLPKVES PEEIQWAVCE ETLKVGPQVG LFLDAVVFGG EDFRASIGAT
SSKETLDILY ARQKIVVIAK AFGLQAIDLV YIDFRDGAGL LRQSREGAAM GFTGKQVIHP
NQIAVVQEQF SPSPEKVKWA EELIAAFKEH QQLGKGAFTF QGSMIDMPLL KQAQNTVTLA
TSIKEK
//
