ID A0A2I3RKW8_PANTR Unreviewed; 2054 AA.
AC A0A2I3RKW8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Fer-1 like family member 4 {ECO:0000313|Ensembl:ENSPTRP00000065303.1};
GN Name=FER1L4 {ECO:0000313|Ensembl:ENSPTRP00000065303.1,
GN ECO:0000313|VGNC:VGNC:108862};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000065303.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000065303.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000065303.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR EMBL; AC160565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC161626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000089531.1; ENSPTRP00000065303.1; ENSPTRG00000049349.1.
DR VGNC; VGNC:108862; FER1L4.
DR GeneTree; ENSGT00940000160586; -.
DR InParanoid; A0A2I3RKW8; -.
DR OMA; GFTHKTR; -.
DR Proteomes; UP000002277; Chromosome 20.
DR Bgee; ENSPTRG00000049349; Expressed in primary visual cortex and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007009; P:plasma membrane organization; IBA:GO_Central.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF36; FER-1-LIKE PROTEIN 4; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR PROSITE; PS50004; C2; 5.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2016..2040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 210..329
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 398..531
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 999..1126
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1495..1614
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1735..1884
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1921..1946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2054 AA; 230005 MW; 9494BCFF8E45E6D6 CRC64;
TRATTNRADR HPRPTSEAHL SSSEQALPRK QEKFTVVQKQ ISVRSLFRWP HYGAPLAGEC
LSVQVVNCSR VFSPRPLGTL VISLQQLQNA GHLVLREALV DENLRVSPIE VELDLKYQPP
EGATGAWSEE DFGAPIQDSF ELIIPNMGFQ ELEPGEAQLE RRAVALGRRL ARSLGQQDNE
ENELELELEQ DLDDEPDVEL SGVMFSPLKS RARALAHGDP FQVSRAQDFQ VGVTVLEAQK
LVGVNINPYV AVQVGGQRRV TATQRGTSCP FYNEYFLFEF HDTRLHLQDL LLEITVSGVG
VTSVLQRRGD EKAAGLTPPS PQAFHSQTLP FMATRIGTFR MDLGIILDQP DGQFYQRWAP
LHDPRDTRAG TKGFVKVTLS VRARGDLPPP MLPPAPGHCS DIEKNLLLPR GVPAERPWAR
LRVRLYRAEG LPALRPGLLG SLARALHDQR VLVEPYVRVS FLGQEGETSV RAEAAAPEWN
EQLSFVELFP PLTRSLRLQL RDDAPLVDAA LATHVLDLRR ISHPGRAAGF NPTFGPAWVP
LYGSPPGAGL RDSLQGLNEG VGQGIWFRGR LLLAVSMQVL EGRAEPEPPQ AQQGSTLSRL
TRKKKKKARR DQTPKAVPQH LDASPGAEGP EIPRAMEVEV EELLPLPENV LAPCEDFLLF
GVLFEATMID PAVASQPISF EISIGNPGRG VDFHLAPTDP CCSGAGRSRA GEGTEGAAVE
AQPLLGPRPE EEKEEEEPGT PAQRPEPMDG SGPYFCLPLR HCKPCMHVWS CWEDHTWRLQ
SSNCVRKVAE RLDQGLQEVE RLQRRPGPGA CAQLKQALEV LVAGSRQFCR GAERRTMTRP
NALDRCRGKL LVHSLNLLAK QGLRLLRGLR RNNVQKKVAL AKKLLAKLRF LAEELFAYLP
LALVIHPQPQ PPLPDVLVWM LSGQRHVAWA RIPAQDVLFS VVEEERGRDC GKIQSLMLTA
PGAAPGEVCA KLELFLWLGL GKQAKACTSE LPPDLLPEPS AGLPSSLHRD DFSYFQLRAH
LYQARGVLAA DDSGLSDPFA RVLISTQCQT TRVLEQTLSP LWNELLVFEQ LIVDGRREHL
QEEPPLVIIN VFDHNKFGPP VFLGRALAAP RVKLMEDPYQ RPELQFFPLR KGPRAAGELI
AAFELIELDY SGRLEPSVPS DVEPQDLAPL VEPHSGRLSL PPNVCPVLRE FRVEVLFWGL
RGLGRVHLFE VEQPQVVLEV AGQRVESEVL ASYRERPNFT ELVRHLTVVF KDTAPLFHPQ
DLPEQPYLQP PLSILVIERR AFGRTVLVGS HIVPHMLRFT FRGHEDPPEE EGEMEETGDM
MPKGPQGQKS LDPFLAEAGI SRQLLKMGKR LAVLGMVLGP GLEEDIPDPE ELDWWSKYYA
SLQELQGQHN LDEDEMDDPG DSDGVNLISM VGEIQDQGEA EVKGTVSPKK AVATLKIYNR
SLEEEFNHFE DWLNVFPLSR GQGGQDGGGE EEGSGHLVGK FKGSFLIYPE SEAVSFSEPQ
ISRGIPQNRP IKLLVRVYIV KATNLAPADP NGKADPYVVV SAGRERQDTK ERYIPKQLNP
IFGEILELSI SLPAETELTV AVFDHDLVGS DDLIGETHID LENRFYSHHR ANCGLASQYE
VWVQQGPQED GYNAWRDAFR PSQILAGLCQ RCGLPAPEYR AGAVKVGSKV FLTPPETLPP
EAQALLVLRR WQEMPGFGIQ LVPEHVETRP LYHPHSPGLL QGSLHMWIDI FPQDVPAPPP
VDIKPRQPIS YELRVVIWNT EDVVLDDENP LTGEMSSDIY VKSWVKGLEH DKQETDVHFN
SLTGEGNFNW RFVFRFDYLP TEREVSVRRR SGPFALEEAE FRQPAVLVLQ VWDYDRISAN
DFLGSLELQL PDMVRGARGP ELCSVRLARD GAGSRCNLFR CRRLRGWWPV VKLKEAEDVE
REAQEAQAGK KKRKQRRRKG RPEDLEFTDT GGNVYILTGK VEAEFELLTV EEAEKRPVGK
GRKQPEPLEK PSRPKTSFNW FVNPLKTFVF FIWRRYWRIL VLLLLLVLLT VFLLLVFYTI
PGQISQVIFR PLHK
//
