ID A0A2I3RM12_PANTR Unreviewed; 516 AA.
AC A0A2I3RM12;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 08-NOV-2023, entry version 20.
DE RecName: Full=RACGAP1 {ECO:0008006|Google:ProtNLM};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000065728.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000065728.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000065728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AACZ04012847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RM12; -.
DR Ensembl; ENSPTRT00000104793.1; ENSPTRP00000065728.1; ENSPTRG00000052454.1.
DR GeneTree; ENSGT00940000154610; -.
DR InParanoid; A0A2I3RM12; -.
DR OMA; QFTINTD; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000052454; Expressed in fibroblast.
DR GO; GO:0097149; C:centralspindlin complex; IBA:GO_Central.
DR GO; GO:0032154; C:cleavage furrow; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR GO; GO:0051256; P:mitotic spindle midzone assembly; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46199:SF1; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 183..232
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 246..430
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 516 AA; 57437 MW; 57FDD3D0C76418CB CRC64;
MDTTMLNMRN LFEQLVRGAE IISEGNELQF IQLVKDFEDF FKKWERTDYE LGKYKDLLIK
AETDDESGSI LSGISFDKTD EPLDCDSSLV KTFKLKQREK RCSSSRQFVD GPSGPVKKTR
SIVAKTTVTV PNDGGPIKAV STIETVPYWT RSQRKTGTLQ PWNSDPTLNN NVGTPQSNRG
MCLHDFVSKT VIKPEFYVPC GKQIKFGKLS LKCQDCCVIS PPECRDHCPL PCIPTLIGTP
VKIGEGMLAD FVSQTFPMIP PIVVHCVNEI EQRGLTETGL YRISGCDGTK FLRVKTVPLV
SKVDDIHAIC SFLKDFLRNF KEPLLTFRLN KAFMEAAAIT DEDNSISAMY QAVGELPQAN
RDTLAFLMIH LQRVAQSPYT KMNVANLAEV FGSTIVAHAV PNPDPVTMLQ DIKCQPKVVE
HLLSLPLEYW SQFTINTDPL HVTENSNAFS TPDIKVSLLG PVNTPEHWLL KTPSSSSLSQ
RVCSTLTKNA PRFGSKSKSA TNLGRQGNLF ASSMLK
//