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Database: UniProt
Entry: A0A2I3RN19_PANTR
LinkDB: A0A2I3RN19_PANTR
Original site: A0A2I3RN19_PANTR 
ID   A0A2I3RN19_PANTR        Unreviewed;       622 AA.
AC   A0A2I3RN19;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A3 {ECO:0000313|Ensembl:ENSPTRP00000066057.1,
GN   ECO:0000313|VGNC:VGNC:8759};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000066057.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000066057.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000066057.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; AACZ04028340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC190236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3RN19; -.
DR   Ensembl; ENSPTRT00000098338.1; ENSPTRP00000066057.1; ENSPTRG00000022537.5.
DR   VGNC; VGNC:8759; SLC26A3.
DR   GeneTree; ENSGT01070000253775; -.
DR   OMA; ALYWIPK; -.
DR   Proteomes; UP000002277; Chromosome 7.
DR   Bgee; ENSPTRG00000022537; Expressed in skeletal muscle tissue and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        37..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        68..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        222..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        251..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        338..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        375..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        433..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          475..575
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   622 AA;  68713 MW;  78474FCC325BB430 CRC64;
     MLLRKIIKRQ KDIIRHFWII SKCVVASWLP AYRLKEWLLS DIVSGISTGI VAVLQGLAFA
     LLVDIPPVYG LYASFFPAII YLFLGTSKHI SVGPFPILSM MVGLAVSGAV SKAVPDRNAT
     TLGLSNNSNN SSLLDDKRVT VAASVTVLSG IIQLAFGILR IGFVVIYLSE SLISGFTTAA
     AVHVLVSQLK FIFQLTVPSH NDPLSIFKVL VSVFSQIEKT NIADLVTALI VLLVVSIVKE
     INQRFKDKLP VPIPIEFIMT VIAAGVSYGC DFKNRFKVAV VGDMNPGFQP PITPDVQAFQ
     NTIGDCFGIA MVAFAVAFSV ASVYSLKYDY PLDGNQELIA LGLGNIVCGV FRGFAGSTAL
     SRSAVQESTG GKTQIAGLIG AIIVLIVLLA IGFLLAPLQK SVLAALALGN LKGMLMQFAE
     IGRLWRKDKY DCLIWIMTFI FTIVLGLGLG LAASVAFQLL TIEKKCHWLR EQCPSPIYFA
     NIGFFRQKLI DAVGFSPLRI LRKRNKALRK IRKLQKQGLL QVTPILQEFI RIKVDVYIVG
     TDDDFIEKLN RYEFFDGEVK NSIFFLTIHD AVLHILMKKD YSTSKFNPSQ EKDGKIDFTI
     NTNGGLRNRV YEVRFFNRFI FT
//
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