ID A0A2I3RN66_PANTR Unreviewed; 1692 AA.
AC A0A2I3RN66; A0A2J8KLN4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tight junction protein 1 {ECO:0000313|Ensembl:ENSPTRP00000066146.1};
GN Name=TJP1 {ECO:0000313|Ensembl:ENSPTRP00000066146.1,
GN ECO:0000313|VGNC:VGNC:13429};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000066146.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000066146.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000066146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AACZ04060766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04060767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016783331.1; XM_016927842.1.
DR Ensembl; ENSPTRT00000086853.1; ENSPTRP00000066146.1; ENSPTRG00000006846.7.
DR GeneID; 453253; -.
DR CTD; 7082; -.
DR VGNC; VGNC:13429; TJP1.
DR GeneTree; ENSGT00940000155164; -.
DR OrthoDB; 2904077at2759; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000006846; Expressed in lung and 21 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12026; SH3_ZO-1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005418; ZO-1.
DR InterPro; IPR035597; ZO-1_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF25; TIGHT JUNCTION PROTEIN ZO-1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01598; ZONOCCLUDNS1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 27..114
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 190..268
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 425..506
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 520..588
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 694..795
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 1558..1692
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 106..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..868
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1692 AA; 189716 MW; 89E9F6E7062C9D32 CRC64;
MERNTFSMDC HSKSTAMEET AIWEQHTVTL HRAPGFGFGI AISGGRDNPH FQSGETSIVI
SDVLKGGPAE GQLQENDRVA MVNGVSMDNV EHAFAVQQLR KSGKNAKITI RRKKKVQIPV
SRPDPEPVSD NEEDSYDEEI HDPRSGRSGV VNRRSEKIWP RDRSASRERS LSPRSDRRSV
ASSQPAKPTK VTLVKSRKNE EYGLRLASHI FVKEISQDSL AARDGNIQEG DVVLKINGTV
TENMSLTDAK TLIERSKGKL KMVVQRDERA TLLNVPDLSD SIHSANASER DDISEIQSLA
SDHSGRSHDR PPRRSRSRSP DQRSEPSDHS RHSPQQPSNG SLRSRDEERI SKPGAVSTPV
KHADDHTPKT VEEVTVERNE KQTPSLPEPK PVYAQVGQPD VDLPVSPSDG VLPNSTHEDG
ILRPSMKLVK FRKGDSVGLR LAGGNDVGIF VAGVLEDSPA AKEGLEEGDQ ILRVNNVDFT
NIIREEAVLF LLDLPKGEEV TILAQKKKDV YRRIVESDVG DSFYIRTHFE YEKESPYGLS
FNKGEVFRVV DTLYNGKLGS WLAIRIGKNH KEVERGIIPN KNRAEQLASV QYTLPKTAGG
DRADFWRFRG LRSSKRNLRK SREDLSAQPV QTKFPAYERV VLREAGFLRP VTIFGPIADV
AREKLAREEP DIYQIAKSEP RDAGTDQRSS GIIRLHTIKQ IIDQDKHALL DVTPNAVDRL
NYAQWYPIVV FLNPDSKQGV KTMRMRLCPE SRKSARKLYE RSHKLRKNNH HLFTTTINLN
SMNDGWYGAL KEAIQQQQNQ LVWVSEGKAD GATSDDLDLH DDRLSYLSAP GSEYSMYSTD
SRHTSDYEDT DTEGGAYTDQ ELDETLNDEV GTPPESAITR SSEPVREDSS GMHHENQTYP
PYSPQAQPQP IHRIDSPGFK PASQQVYRKD PYPEEMMRQN HVLKQPAVSH PGHRPDKEPN
LTYEPQLPYV EKQASRDLEQ PTYRYESSSY TDQFSRNYEH RLRYEDRVPM YEEQWSYYDD
KQPYPSRPPF DNQHSQDLDS RQHPEESSER GYFPRFEEPA PLSYDSRPRY EQAPRASALR
HEEQPAPGYD THGRLRPEAQ PHPSAGPKPA ESKQYFEQYS RSYEQVPPQG FTSRAGHFEP
LHGAAAVPPL IPSSQHKPEA LPSNTKPLPP PPTQTEEEED PAMKPQSVLT RVKMFENKRS
ASLETKKDVN DTGSFKPPEV ASKPSGAPII GPKPTSQNQF SEHDKTLYRI PEPQKPQLKP
PEDIVRSNHY DPEEDEEYYR KQLSYFDRRS FENKPPAHIA ASHLSEPAKP AHSQNQSNFS
SYSSKGKPPE ADGVDRSFGE KRYEPIQATP PPPPLPSQYA QPSQPVTSAS LHIHSKGAHG
EGNSVSLDFQ NSLVSKPDPP PSQNKPATFR PPNREDTAQP AFYPQKSFPD KAPVNGTEQT
QKTVTPAYNR FTPKPYTSSA RPFERKFESP KFNHNLLPSE TAHKPELSSK TPTSPKTLVK
SHSLAQPPEF DSGVETFSIH AEKPKYQINN ISTVPKAIPV SPSAVEEDED EDGHTVVATA
RGIFNSNGGV LSSIETGVSI IIPQGAIPEG VEQEIYFKVC RDNSILPPLD KEKGETLLSP
LVMCGPHGLK FLKPVELRLP HCASMTPDGW SFALKSSDSS SGDPKTWQNK CLPGDPNYLV
GANCVSVLID HF
//
