ID   A0A2I3RN98_PANTR        Unreviewed;       584 AA.
AC   A0A2I3RN98;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Glucosamine (N-acetyl)-6-sulfatase {ECO:0000313|Ensembl:ENSPTRP00000066176.1};
GN   Name=GNS {ECO:0000313|Ensembl:ENSPTRP00000066176.1,
GN   ECO:0000313|VGNC:VGNC:13094};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000066176.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000066176.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000066176.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- PTM: The conversion to 3-oxoalanine (also known as C-formylglycine,
CC       FGly), of a serine or cysteine residue in prokaryotes and of a cysteine
CC       residue in eukaryotes, is critical for catalytic activity.
CC       {ECO:0000256|PIRSR:PIRSR036666-50}.
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACZ04013035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003952183.1; XM_003952134.3.
DR   AlphaFoldDB; A0A2I3RN98; -.
DR   Ensembl; ENSPTRT00000086822.1; ENSPTRP00000066176.1; ENSPTRG00000005176.5.
DR   GeneID; 467054; -.
DR   KEGG; ptr:467054; -.
DR   CTD; 2799; -.
DR   VGNC; VGNC:13094; GNS.
DR   GeneTree; ENSGT00940000158420; -.
DR   InParanoid; A0A2I3RN98; -.
DR   OrthoDB; 1365192at2759; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000005176; Expressed in adult mammalian kidney and 21 other cell types or tissues.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0005539; F:glycosaminoglycan binding; IBA:GO_Central.
DR   GO; GO:0008449; F:N-acetylglucosamine-6-sulfatase activity; IBA:GO_Central.
DR   GO; GO:0030203; P:glycosaminoglycan metabolic process; IEA:InterPro.
DR   CDD; cd16147; G6S; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR012251; GlcNAc_6-SO4ase.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43108:SF5; N-ACETYLGLUCOSAMINE-6-SULFATASE; 1.
DR   PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF036666; G6S; 2.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          79..416
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   MOD_RES         123
FT                   /note="3-oxoalanine (Cys)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036666-50"
SQ   SEQUENCE   584 AA;  65751 MW;  218896164706B12C CRC64;
     MRLLPLAPGR LRRGSPRHLP SCSPALLLLV LGGCLGVFGV AAGTRRPNVV LLLTDDQDEV
     LGGMAFSEYS TTNCQTGLQG EELRQEHLRT YLAPSRTPLK KTKALIGEMG MTFSSAYVPS
     ALCCPSRASI LTGKYPHNHH VVNNTLEGNC SSKSWQKIQE PNTFPAILRS MCGYQTFFAG
     KYLNEYGAPD AGGLEHVPLG WSYWYALEKN SKYYNYTLSI NGKARKHGEN YSVDYLTDVL
     ANVSLDFLDY KSNFEPFFMM IATPAPHSPW TAAPQYQKAF QNVFAPRNKN FNIHGTNKHW
     LIRQAKTPMT NSSIQFLDNA FRKRWQTLLS VDDLVEKLVK RLEFTGELNN TYIFYTSDNG
     YHTGQFSLPI DKRQLYEFDI KVPLLVRGPG IKPNQTSKML VANIDLGPTI LDIAGYDLNK
     TQMDGMSLLP ILRGASNLTW RSDVLVEYQG EGRNVTDPTC PSLSPGVSQC FPDCVCEDAY
     NNTYACVRTM SALWNLQYCE FDDQEVFVEV YNLTADPDQI TNIAKTIDPE LLGKMNYRLM
     MLQSCSGPTC RTPGVFDPGY RFDPRLMFSN RGSVRTRRFS KHLL
//