ID   A0A2I3RRN5_PANTR        Unreviewed;       189 AA.
AC   A0A2I3RRN5;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Polypyrimidine tract binding protein 1 {ECO:0000313|Ensembl:ENSPTRP00000067361.1};
GN   Name=PTBP1 {ECO:0000313|Ensembl:ENSPTRP00000067361.1,
GN   ECO:0000313|VGNC:VGNC:2267};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000067361.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000067361.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000067361.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AACZ04000718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3RRN5; -.
DR   Ensembl; ENSPTRT00000110149.1; ENSPTRP00000067361.1; ENSPTRG00000010165.6.
DR   VGNC; VGNC:2267; PTBP1.
DR   GeneTree; ENSGT01050000244924; -.
DR   Proteomes; UP000002277; Chromosome 19.
DR   Bgee; ENSPTRG00000010165; Expressed in cortex of kidney and 20 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0043484; P:regulation of RNA splicing; IEA:UniProt.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR006536; HnRNP-L/PTB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR   PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR   PANTHER; PTHR15592:SF19; POLYPYRIMIDINE TRACT-BINDING PROTEIN 1; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF13893; RRM_5; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          1..69
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          112..187
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   189 AA;  21046 MW;  875FE49B772F66ED CRC64;
     MDGILLESAF QAVLFPGVYG DVQRVKILFN KKENALVQMA DGNQAQLAMS HLNGHKLHGK
     PIRITLSKHQ NVQLPREGQE DQGLTKDYGN SPLHRFKKPG SKNFQNIFPP SATLHLSNIP
     PSVSEEDLKV LFSSNGGVVK GFKFFQKDRK MALIQMGSVE EAVQALIDLH NHDLGENHHL
     RVSFSKSTI
//