ID A0A2I3RRX5_PANTR Unreviewed; 703 AA.
AC A0A2I3RRX5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=G2/M-phase specific E3 ubiquitin protein ligase {ECO:0000313|Ensembl:ENSPTRP00000067408.1};
GN Name=G2E3 {ECO:0000313|Ensembl:ENSPTRP00000067408.1,
GN ECO:0000313|VGNC:VGNC:48960};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000067408.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000067408.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000067408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04059444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RRX5; -.
DR Ensembl; ENSPTRT00000103828.1; ENSPTRP00000067408.1; ENSPTRG00000006234.5.
DR VGNC; VGNC:48960; G2E3.
DR GeneTree; ENSGT00950000182865; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006234; Expressed in thymus and 22 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd15669; ePHD_PHF7_G2E3_like; 1.
DR CDD; cd15496; PHD_PHF7_G2E3_like; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042013; PHF7/G2E3_ePHD.
DR InterPro; IPR042012; PHF7/G2E3_PHD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12420:SF37; G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR12420; PHD FINGER PROTEIN; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 8..125
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 526..689
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 663
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 703 AA; 80106 MW; 4A4CF2AC5E28F794 CRC64;
LNQSEGGQST CVFCRKNDDC PNKYGEKKTK EKWNLTVHYY CLLMSSGIWQ RGKEEEGVYG
FLIEDIRKEV NRASKLKCCV CKKNGASIGC VAPRCKRSYH FPCGLQRECI FQFTGNFASF
CWDHRPVQII TSNNYRESLP CTICLEFIEP IPSYNVLRSP CCKNAWFHRD CLQVQAINAG
VFFFRCTICN NSDIFQKEML RMGIHIPEKD ASWELEENAY QELLQHYERC DVRRCRCKEG
RDYNAPDSKW EIKRCHCCGS SGTHLACSSL RSWEQNWECL ECRGIIYNSG EFQKAKKHVL
PNSNNVGITD CLLEESSPKL PRQSPGSQSK DLLRQGSKFR RNVSTLLIEL GFQIKKKTKR
LYINKANIWN SALDAFRNRN FNPSYAIEVA YVIENDNFGS EHPGSKQEFL SLLMQHLENS
SLFEGSLSKN LSLNSQALKE NLYYEAGKML AISLVHGGPS PGFFSKTLFN CLVYGPENTQ
PILDDVSDFD VAQIIIRINT ATTVADLKSI INECYNYLEL IGCLRLITTL SDKYMLVKDI
LGYHVIQRVH TPFESFKQGL KTLGVLEKIQ AYPEAFCSIL CHKPESLSAK ILSELFTVHT
LPDVKALGFW NSYLQAVEDG KSTTTMEDIL IFATGCSSIP PAGFKPTPSI ECLHVDFPVG
NKCNNCLAIP ITNTYKEFQE NMDFTIRNTL RLEKEESSHY IGH
//
