ID A0A2I3RSV8_PANTR Unreviewed; 1393 AA.
AC A0A2I3RSV8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSPTRP00000067793.1};
GN Name=TRPM2 {ECO:0000313|Ensembl:ENSPTRP00000067793.1,
GN ECO:0000313|VGNC:VGNC:7467};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000067793.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000067793.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000067793.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136134; DOI=10.1038/nature04101;
RA Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T., Rozen S.,
RA Wilson R.K., Page D.C.;
RT "Conservation of Y-linked genes during human evolution revealed by
RT comparative sequencing in chimpanzee.";
RL Nature 437:100-103(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000067793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}.
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DR EMBL; AACZ04005777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04005782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04066634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL954247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000104806.1; ENSPTRP00000067793.1; ENSPTRG00000013977.6.
DR VGNC; VGNC:7467; TRPM2.
DR GeneTree; ENSGT00940000156404; -.
DR InParanoid; A0A2I3RSV8; -.
DR Proteomes; UP000002277; Chromosome 21.
DR Bgee; ENSPTRG00000013977; Expressed in Brodmann (1909) area 10 and 16 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0072571; F:mono-ADP-D-ribose binding; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071415; P:cellular response to purine-containing compound; IEA:Ensembl.
DR GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
DR GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IEA:Ensembl.
DR CDD; cd03670; ADPRase_NUDT9; 1.
DR Gene3D; 3.40.50.450; -; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF2; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 707..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1244..1388
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 1099..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 158088 MW; 0C5069B1DE8F7887 CRC64;
MEPSALRKAG SEQEGFEGLP RRVTDLGMVS NLRRSNSSLF KSWRLQCPFG NNDKQESLSS
WIPENIKKKE CVYFVESSKL SDAGKVVCQC GYTHEQHLEE ATKPHTFQGT QWDPKKHVQE
MPTDAFGDIV FTGLSQKVKK YVRVSQDTPS SVIYHLMTQH WGLEVPNLLI SVTGGAKNFN
MKPRLKSIFR RGLVKVAQTT GAWIITGGSH AGVMKQVGEA VRDFSLSSSY KEGELITIGV
ATWGTVHRRE GLIHPTGSFP AEYILDEDGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL
RTRLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NATTNGTPCV VVEGSGRVAD
VIAQVANLPV SDITISLIQQ KLSVFFQEMF ETFTESRIVE WTKKIQDIVR RRQLLTVFRE
GKDGQQDVDV AILQALLKAS RSQDHFGHEN WDHQLKLAVA WNRVDIARSE IFTDEWQWKP
SDLHPTMTAA LISNKPEFVK LFLENGVQLK EFVTWDTLLY LYENLDPSCL FHSKLQKVLA
EEPECPACAP AAPRLQMHHV AQVLRELLGD FTQPLYPRPP HNGRPRLLLP VPHVKLNVQG
VSLWSLYKRS SGHVTFTMDP IRDLLIWAIV QNRRELAGII WAQSQDCIAA ALACSKILKE
LSKEEEDTDS SEEMLALAEE YEHRAILFYD PDECGLMKKA ALYFSDFWNK LDVGAILLFV
AGLTCRLIPV TLYPGRVILS LDFILFCLRL MHIFTISKTL GPKIIIVKRM MKDVFFFLFL
LAVWVVSFGV AKQAILIHNE RRVDWLFRGA VYHSYLTIFG QIPGYIDGVN FNPEHCSPNG
TDPYKPKCPE SDATQQRPAF PEWLTVLLLC LYLLFTNILL LNLLIAMFNY TFQQVQEHTD
QIWKFQRHDL IEEYHGRPAA PPPFILLSHL QLFIKRVVLK TPAKRHKQLK NKLEKNEEAA
LLSWEIYLKE NYLQNRQFQQ KQRPEQKIED ISNKAGMELW GSRTSSVCKS RQFLHLTVVE
SRGSEKAPVT TLACLQGCLG KHGRVDAMVD LLDLDPLKRM GSMEQRLASL EEQVAQTARA
LHWIVRTLRA SGFSSEADVP TLASQKAVEE PDAEPGGRKK TEEPGDSYHV NARHLLYPNC
PVTRFPVPNE KVPWETEFLI YDPPFYTAER KDAAAMDPVG DTLEPLFTIQ YNVVDGLRDR
RSFHGPYTVQ AGLPLNPMGR TGLRGRGSLS CFGPNHTLYP MVTRWRRNED GAICRKSIKK
MLEVLVVKLP LSEHWALPGG SREPGETLPR KLKRILRQEH WPSFENLLKC GMEVYKGYMD
DPRNTDNAWI ETVAVSVHFQ DQNDVELNRL NSNLHACDSG ASIRWQVVDR RIPLHANHKT
LLQKAAAEFG AHY
//
