ID A0A2I3RVR1_PANTR Unreviewed; 587 AA.
AC A0A2I3RVR1; A0A2J8P7T3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Ankyrin repeat and SOCS box containing 14 {ECO:0000313|Ensembl:ENSPTRP00000068816.1};
GN Name=ASB14 {ECO:0000313|Ensembl:ENSPTRP00000068816.1,
GN ECO:0000313|VGNC:VGNC:11325};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000068816.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000068816.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000068816.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04000347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009443963.1; XM_009445688.2.
DR AlphaFoldDB; A0A2I3RVR1; -.
DR STRING; 9598.ENSPTRP00000068816; -.
DR PaxDb; 9598-ENSPTRP00000025988; -.
DR Ensembl; ENSPTRT00000104125.1; ENSPTRP00000068816.1; ENSPTRG00000015046.5.
DR GeneID; 470829; -.
DR KEGG; ptr:470829; -.
DR CTD; 142686; -.
DR VGNC; VGNC:11325; ASB14.
DR GeneTree; ENSGT00940000156550; -.
DR InParanoid; A0A2I3RVR1; -.
DR OMA; QGWLPVH; -.
DR OrthoDB; 5479200at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015046; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03730; SOCS_ASB14; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT REPEAT 116..148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 149..181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 182..214
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 215..247
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 248..280
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 313..345
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 385..417
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 529..576
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 587 AA; 65240 MW; 204EFFDA03FE025A CRC64;
MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SFHSFLSADY KKIVETIEKG
KEDALSHLTK YHSAFGEADE IGRIPLHKAA VQLNRKILEI TLSASDPSLW EQTTHNGETP
LFLAVSSCLL ENATFLLLNG CNPNAKNFEG NSPLLTAVLR DCYDMAALLI NYGADVNLRC
ANERTALHEA AKLGREDMVK LMLVSGAHPD PQSTYGFTPL ALAAQSGHTE IMEMLLRKGA
NAHGQASDSS SILLEAASGG NPDAVALLLE YGADANIPKN SGHLPIHVAA DRGHLLALKI
LIPVTDLAAI KQSGISPVHC AAAGAHPQCL ELLIQAGFDV NFMLDQRINK HYDDHRKSAL
YFAVSNSDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LISLLLRHGA NVNYFCRVNP
LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGDKVH PSYTVEGWTS TVIKDTKFCE
VITLSWLQHL SGKVVRVMLD YVDQVRICSK LKAVLQKQGI WSEIHFILTN PRSLKHLCRL
KIRKCMGRLH LRCPVFMSFL PLPNRLKAYV LYKEYDLYGQ GIFTGTW
//
