ID A0A2I3RVZ3_PANTR Unreviewed; 1916 AA.
AC A0A2I3RVZ3; A0A2J8NRA6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSPTRP00000068893.1};
GN Name=DENND4A {ECO:0000313|Ensembl:ENSPTRP00000068893.1,
GN ECO:0000313|VGNC:VGNC:6461};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000068893.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000068893.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000068893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AACZ04064624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009427667.1; XM_009429392.2.
DR RefSeq; XP_009427668.1; XM_009429393.2.
DR RefSeq; XP_009427670.1; XM_009429395.2.
DR RefSeq; XP_016783872.1; XM_016928383.1.
DR RefSeq; XP_016783873.1; XM_016928384.1.
DR STRING; 9598.ENSPTRP00000068893; -.
DR Ensembl; ENSPTRT00000081500.1; ENSPTRP00000068893.1; ENSPTRG00000007186.6.
DR GeneID; 467708; -.
DR KEGG; ptr:467708; -.
DR CTD; 10260; -.
DR VGNC; VGNC:6461; DENND4A.
DR GeneTree; ENSGT00940000155836; -.
DR InParanoid; A0A2I3RVZ3; -.
DR OrthoDB; 1079051at2759; -.
DR Proteomes; UP000002277; Chromosome 15.
DR Bgee; ENSPTRG00000007186; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 42..200
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 192..641
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 809..843
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 939..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1916 AA; 214913 MW; 022BD26AA6D993B1 CRC64;
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV IIKSLGEEVP
QDYICIDVTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL TDLGVLYDWK ERLKQGCEII
QSTPYGRPAN ISGSTSSQRI YITYRRASEN MTQNTLAVTD ICIIIPSKGE SPPHTFCKVD
KNLNNSMWGS AVYLCYKKSV AKTNTISYKA GLICRYPQED YESFSLPESV PLFCLPMGAT
IECWPSNSKY PLPVFSTFVL TGASAEKVYG AAIQFYEPYS EENLTEKQRL LLGLTSADGK
SDSSKTIHTN KCICLLSHWP FFDAFRKFLT FLYRYSISGP HVLPIEKHIS HFMHKVPFPS
PQRPRILVQL SPHDNLILSQ PVSSPLPLSG GKFSTLLQNL GPENAVTLLV FAVTEHKILI
HSLRPSVLTS VTEALVSMIF PFHWPCPYVP LCPLALADVL SAPCPFIVGI DSRYFDLYDP
PPDVSCVDVD TNTISQIGDK KNVAWKILPK KPCKNLMNTL NNLHQQLAKL QQRPRDDGLM
DLAMNDYDFN SGKRLHMIDL EIQEAFLFFM ASILKGYRSY LRPITQAPSE TATDAASLFA
LQAFLRSRDR SHQKFYNMMT KTQMFIRFIE ECSFVSDKDA SLAFFDDCVD KVDMDKSGEV
RLIELDESFK SEHTVFVTPP EIPHLPNGEE PPLQYSYNGF PVLRNNLFER PEGFLQAKKN
KLPSKSSSPN SPLPMFRRTK QEIKSAHKIA KRYSSIPQMW SRCLLRHCYG LWFICLPAYV
KVCHSKVRAL KTAYDVLKKM QSKKMDPPDE VCYRILMQLC GQYDQPVLAV RVLFEMQKAG
IDPNAITYGY YNKAVLESTW PSRSRSGYFL WTKVRNVVLG VTQFKRALKK HAHLSQTTLS
ADGSDLDAVS HGSMDSGHGT HTVEQAPFNT GLIKVYATDD RSSTGGQSDL GYNSLSKDEV
RRGDTSTEDI QEEKDKKGSD CSSLSESEST KGSADCLPKL SYQNSSSIVR LTGTSNNSAD
KISGESMEST PELLLISSLE DTNETRNIQS RCFRKRHKSD NETNLQQQVV WGNRNRNLSG
GVLMGFMLNR INQEATPGDI VERLGADAKI LSNVISKSTR PNTLDIGKPP LRSKRDSLEK
ESSDDDTPFD GSNYLADKVD SPVIFDLEDL DSETDGSKAG CVATQNPKRI QRMNSSFSVK
PFEKTDVATG FDPLSLLVAE TEQQQKEEEE EDEDDSKSIS TPSARRDLAE EIVMYMNNMS
SPLTSRTPSI DLQRACDDKL NKKSPPLVKA CRRSSLPPNS PKPVRLTKSK SYTKSEEKPR
DRLWSSPAFS PTCPFREESQ DTLTHSSPSF NLDTLLVPKL DVLRNSMFTA GKGVAEKASK
WYSRFTMYTT SSKDQSSDRT SLSSVGAQDS ESTSLTDEDV CHELEGPISS QETSATSGTK
RIDLSRISLE SSASLEGSLS KFALPGKSEV TSSFNASNTN IFQNYAMEVL ISSCSRCRTC
DCLVHDEEIM AGWTADDSNL NTTCPFCGNI FLPFLNIEIR DLRRPGRYFL KSSPSTENMH
FPSSISSQTR QSCISTSASG LDTSALSVQG NFDLNSKSKL QENFCTRSIQ IPANRSKTAM
SKCPIFPMAR SISTSGPLDK EDTGRQKLIS TGSLPATLQG ATDSLGLEWH LPSPDPVTVP
YLSPLVVWKE LESLLENEGD HAITVADFVD HHPIVFWNLV WYFRRLDLPS NLPGLILSSE
HCNKYSKIPR HCMSEDSKYV LIQMLWDNMK LHQDPGQPLY ILWNAHSQSR TLLFETQKYP
MVHLLQKSDN SFNQELLKSM VKSIKMNDVY GPMSQILETL NKCPHFKRQR SLYREILFLS
LVALGRENID IDAFDKEYKM AYDRLTPSQV KSTHNCDRPP STGVMECRKT FGEPYL
//