ID A0A2I3RWP5_PANTR Unreviewed; 868 AA.
AC A0A2I3RWP5; A0A2J8Q6C3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=BCAR1 scaffold protein, Cas family member {ECO:0000313|Ensembl:ENSPTRP00000069143.1};
GN Name=BCAR1 {ECO:0000313|Ensembl:ENSPTRP00000069143.1,
GN ECO:0000313|VGNC:VGNC:10129};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000069143.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000069143.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000069143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; AACZ04039444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016785677.1; XM_016930188.1.
DR AlphaFoldDB; A0A2I3RWP5; -.
DR Ensembl; ENSPTRT00000088550.1; ENSPTRP00000069143.1; ENSPTRG00000008357.6.
DR GeneID; 454246; -.
DR CTD; 9564; -.
DR VGNC; VGNC:10129; BCAR1.
DR GeneTree; ENSGT00950000183008; -.
DR OrthoDB; 2902504at2759; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000008357; Expressed in cortex of kidney and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11569; FAT-like_BCAR1_C; 1.
DR CDD; cd11552; Serine_rich_BCAR1; 1.
DR CDD; cd12001; SH3_BCAR1; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046976; BCAR1_C.
DR InterPro; IPR035745; BCAR1_SH3.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654:SF15; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..63
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 68..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..97
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 93149 MW; DA51918D07A2016B CRC64;
MENVLAKALY DNVAESPDEL SFRKGDIMTV LEQDTQGLDG WWLCSLHGRQ GIVPGNRLKI
LVGMYDKKPA GPGPGPPATP AQPQPGLHAP APPASQYTPM LPNTYQPQPD SVYLVPTPSK
AQQGLYQVPG PSPQFQSPPA KQTSTFSKQT PHHPFPSPAT DLYQVPPGPG GPAQDIYQVP
PSAGMGHDIY QVPPSMDTRS WEGTKPPAKV VVPTRVGQGY VYEAAQPEQD EYDIPRHLLA
PGPQDIYDVP PVRGLLPSQY GQEVYDTPPM AVKGPNGRDP LLEVYDVPPS VEKGLPPSNH
HAVYDVPPSV SKDVPDGPLL REETYDVPPA FAKTKPFDPA RTPLVLAAPP PDSPPAEDVY
DVPPPAPDLY DVPPGLRRPG PGTLYDVPRE RVLPPEVADG GVVDSGVYAV PPPAEREAPA
EGKRLSASST GSTRSSQSAS SLEVAGPGRE PLELEVAVEA LARLQQGVSA TVAHLLDLAG
SAGGTGSWRS PSEPQEPLVQ DLQAAVAAVQ SAVHELLEFA RSAVGNAAHT SDRALHAKLS
RQLQKMEDVH QTLVAHGQAL DAGRGGSGAT LEDLDRLVAC SRAVPEDAKQ LASFLHGNAS
LLFRRTKAPA PGPEGGGTLH PNPTDKTSSI QSRPLPSPPK FTSQDSPDGQ YENSEGGWME
DYDYVHLQGK EEFEKTQKEL LEKGSITRQG KSQLELQQLK QFERLEQEVS RPIDHDLANW
TPAQPLAPGR TGGLGPSDRQ LLLFYLEQCE ANLTTLTNAV DAFFTAVATN QPPKIFVAHS
KFVILSAHKL VFIGDTLSRQ AKAADVRSQV THYSNLLCDL LRGIVATTKA AALQYPSPSA
AQDMVERVKE LGHSTQQFRR VLGQLAAA
//
