ID A0A2I3RX84_PANTR Unreviewed; 524 AA.
AC A0A2I3RX84;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Thymocyte selection associated high mobility group box {ECO:0000313|Ensembl:ENSPTRP00000069311.1};
GN Name=TOX {ECO:0000313|Ensembl:ENSPTRP00000069311.1,
GN ECO:0000313|VGNC:VGNC:2452};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000069311.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000069311.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000069311.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04016030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RX84; -.
DR Ensembl; ENSPTRT00000103463.1; ENSPTRP00000069311.1; ENSPTRG00000020281.3.
DR VGNC; VGNC:2452; TOX.
DR GeneTree; ENSGT00940000159497; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020281; Expressed in thymus and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21995; HMG-box_TOX-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45781; AGAP000281-PA; 1.
DR PANTHER; PTHR45781:SF4; THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 256..324
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 256..324
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 134..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57389 MW; 34967C9F4240DEB4 CRC64;
SQSSGINPPT KPALKQRAIA ECLLLFHSQF DGENMYMSMT EPSQDYVPAS QSYPGPSLES
EDFNIPPITP PSLPDHSLVH LNEVESGYHS LCHPMNHNGL LPFHPQNMDL PEITVSNMLG
QDGTLLSNSI SVMPDIRNPE GTQYSSHPQM AAMRPRGQPA DIRQQPGMMP HGQLTTINQS
QLSAQLGLNM GGSNVPHNSP SPPGSKSATP SPSSSVHEDE GDDTSKINGG EKRPASDMGK
KPKTPKKKKK KDPNEPQKPV SAYALFFRDT QAAIKGQNPN ATFGEVSKIV ASMWDGLGEE
QKQVYKKKTE AAKKEYLKQL AAYRATSYLE STLIYSEPVD VKTSQPPQLI NSKPSVFHGP
SQAHSALYLS SHYHQQPGMN PHLTAMHPSL PRNIAPKPNN QMPVTVSIAN MAVSPPPPLQ
ISPPLHQHLN MQQHQPLTMQ QPLGNQLPMQ VQSALHSPTM QQGFTLQPDY QTIINPTSTA
AQVVTQAMEY VRSGCRNPPP QPVDWNNDYC SSGGMQRDKA LYLT
//
