ID A0A2I3RXE4_PANTR Unreviewed; 1074 AA.
AC A0A2I3RXE4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=LIM and calponin homology domains 1 {ECO:0000313|Ensembl:ENSPTRP00000069381.1};
GN Name=LIMCH1 {ECO:0000313|Ensembl:ENSPTRP00000069381.1,
GN ECO:0000313|VGNC:VGNC:627};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000069381.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000069381.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000069381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04033792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RXE4; -.
DR PaxDb; 9598-ENSPTRP00000045652; -.
DR Ensembl; ENSPTRT00000105343.1; ENSPTRP00000069381.1; ENSPTRG00000016010.7.
DR VGNC; VGNC:627; LIMCH1.
DR GeneTree; ENSGT00950000183159; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016010; Expressed in spleen and 21 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR031865; DUF4757.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15551:SF3; LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR15551; LIM DOMAIN ONLY 7; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF15949; DUF4757; 1.
DR Pfam; PF00412; LIM; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 6..114
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1002..1068
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 174..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 343..428
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 770..811
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 174..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 121127 MW; 009F095952E8BC67 CRC64;
TALKPFNPEK TYVLFFFSFL QQVTGRSFGD KDFRTGLENG ILLCELLNAI KPGLVKKINR
LPTPIAGLDN IILFLRGCKE LGLKESQLFD PSDLQDTSNR VTVKSLDYSR KLKNVLVTIY
WLGKAANSCT SYSGTTLNLK EFEGLLAQMR KETDDIESPK RSIRDSGYID CWDSERSDSL
SPPRHGRDDS FDSLDSFGSR SRQTPSPDVV LRGSSDGRGS DSESDLPHRK LPDVKKDDMS
ARRTSHGEPK SAVPFNQYLP NKSNQTAYVP APLRKKKAER EEYRKSWSTA TSPLGGERPF
RYGPRTPVSD DAESTSMFDM RCEEEAAVQP HSRARQEQLQ LINNQLREED DKWQDDLARW
KSRRRSVSQD LIKKEEERKK MEKLLAGEDG TSERRKSIKT YREIVQEKER RERELHEAYK
NARSQEEAEG ILQQYIERFT ISEAVLERLE MPKILERSHS TEPNLSSFLN DPNPMKYLRQ
QSLPPPKFTA TVETTIARAS VLDTSMSAGS GSPSKTVTPK AVPMLTPKPY SQPKNSQDVL
KTFKVDGKVS VNGETVHREE EKERECPTVA PAHSLTKSQM FEGVARVHGS PLELKQDNGS
IEINIKKPNS VPQELAATTE KTEPNSQGDK NDGGKPRKGN IELASSEPQH FTTTVTRCSP
TVAFVEFPSS PQLKNDVSEE KDQKKPENEM SGKVELVLSQ KVVKPKSPEP EATLTFPFLD
KMPEANQLHL PNLNSQVDSP SSEKSPVTTP FKFWAWDPEE ERRRQEKWQQ EQERLLQERY
QKEQDKLKEE WEKAQKEVEE EERRYYEEER KIIEDTVVPF TVSSSSADQL STSSSMTEGS
GTMNKIDLGN CQDEKQDRRW KKSFQGDDSD LLLKTRESDR LEEKGSLTEG ALAHSGNPVS
KGVHEDHQLD AEAGAPHCGT NPQLAQDPSQ NQQTSNPTHS SEDVKPKTLP LDKSINHQIE
SPSERRKKSP REHFQAGPFS PCSPTPPGQS PNRYKRSISG KKLCSSCGLP LGKGAAMIIE
TLNLYFHIQC FRCGICKGQL GDAVSGTDVR IRNGLLNCND CYMRSRSAGQ PTTL
//
