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Database: UniProt
Entry: A0A2I3RZA1_PANTR
LinkDB: A0A2I3RZA1_PANTR
Original site: A0A2I3RZA1_PANTR 
ID   A0A2I3RZA1_PANTR        Unreviewed;      4904 AA.
AC   A0A2I3RZA1;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000069647};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSPTRP00000069647,
GN   ECO:0000313|VGNC:VGNC:6990};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000069647, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000069647, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000069647}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AACZ04026659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000098647; ENSPTRP00000069647; ENSPTRG00000002149.
DR   VGNC; VGNC:6990; RYR2.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4217   4236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4437   4457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4511   4530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4647   4668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4705   4726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4781   4804       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       85    140       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      147    192       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      200    255       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      261    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      574    784       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1000   1197       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1312   1537       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3960   3995       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      447    467       {ECO:0000256|SAM:Coils}.
FT   COILED     3031   3051       {ECO:0000256|SAM:Coils}.
FT   COILED     3296   3316       {ECO:0000256|SAM:Coils}.
FT   COILED     4349   4382       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4904 AA;  556729 MW;  42AA3946FCCD6440 CRC64;
     EAEDDEVVLQ CTATIHKEQQ KLCLAAEGFG NRLCFLESTS NSKNVPPDLS ICTFVLEQSL
     SVRALQEMLA NTVEKSEGTA QGGGHRTLLY GHAILLRHSY SGMYLCCLST SRSSTDKLAF
     DVGLQEDTTG EACWWTIHPA SKQRSEGEKV RVGDDLILVS VSSERYLHLS YGNGSLHVDA
     AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR LLHGHMDECL TVPSGEHGEE QRRTVHYEGG
     AVSVHARSLW RLETLRVAWS GSHIRWGQPF RLRHVTTGKY LSLMEDKNLL LMDKEKADVK
     STAFTFRSSK EKLDVGVRKE VDGMGTSEIK YGDSVCYIQH VDTGLWLTYQ SVDVKSVRMG
     SIQRKAIMHH EGHMDDGISL SRSQHEESRT ARVIRSTVFL FNRFIRGLDA LSKKAKASTV
     DLPIESVSLS LQDLIGYFHP PDEHLEHEDK QNRLRALKNR QNLFQEEGMI NLVLECIDRL
     HVYSSAAHFA DVAGREAGES WKSILNSLYE LLAALIRGNR KNCAQFSGSL DWLISRLERL
     EASSGILEVL HCVLVESPEA LNIIKEGHIK SIISLLDKHG RNHKVLDVLC SLCVCHGVAV
     RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM RPNIFLGVSE GSAQYKKWYY ELMVDHTEPF
     VTAEATHLRV GWASTEGYSP YPGGGEEWGG NGVGDDLFSY GFDGLHLWSG CIARTVSSPN
     QHLLRTDDVI SCCLDLSAPS ISFRINGQPV QGMFENFNID GLFFPVVSFS AGIKVRFLLG
     GRHGEFKFLP PPGYAPCYEA VLPKEKLKVE HSREYKQERT YTRDLLGPTV SLTQAAFTPI
     PVDTSQIVLP PHLERIREKL AENIHELWVM NKIELGWQYG PVRDDNKRQH PCLVEFCKLP
     EQERNYNLQM SLETLKTLLA LGCHVGISDE HAEDKVKKMK LPKNYQLTSG YKPAPMDLSF
     IKLTPSQEAM VDKLAENAHN VWARDRIRQG WTYGIQQDVK NRRNPRLVPY TLLDDRTKKS
     NKDSLREAVR TLLGYGYNLE APDQDHAARA EVCSGTGERF RIFRAEKTYA VKAGRWYFEF
     ETVTAGDMRV GWSRPGCQPD QELGSDERAF AFDGFKAQRW HQGNEHYGRS WQAGDVVGCM
     VDMNEHTMMF TLNGEILLDD SGSELAFKDF DVGDGFIPVC SLGVAQVGRM NFGKDVSTLK
     YFTICGLQEG YEPFAVNTNR DITMWLSKRL PQFLQVPSNH EHIEVTRIDG TIDSSPCLKV
     TQKSFGSQNS NTDIMFYRLS MPIECAEVFS KTVAGGLPGA GLFGPKNDLE DYDADSDFEV
     LMKTAHGHLV PDRVDKDKEA TKPEFNNHKD YAQEKPSRLK QRFLLRRTKP DYSTSHSARL
     TEDVLADDRD DYDFLMQTST YYYSVRIFPG QEPANVWVGW ITSDFHQYDT GFDLDRVRTV
     TVTLGDEKGK VHESIKRSNC YMVCAGESMS PGQGRNNNGL EIGCVVDAAS GLLTFIANGK
     ELSTYYQVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP LSAGLFKSEH KNPVPQCPPR
     LHVQFLSHVL WSRMPNQFLK VDVSRISERQ GWLVQCLDPL QFMSLHIPEE NRSVDILELT
     EQEELLKFHY HTLRLYSAVC ALGNHRVAHA LCSHVDEPQL LYAIENKYMP GLLRAGYYDL
     LIDIHLSSYA TARLMMNNEY IVPMTEETKS ITLFPDENKK HGLPGIGLST SLRPRMQFSS
     PSFVSISNEC YQYSPEFPLD ILKSKTIQML TEAVKEGSLH ARDPVGGTTE FLFVPLIKLF
     YTLLIMGIFH NEDLKHILQL IEPSVFKEAA TPEEESDTLE KELSVDDAKL QGAGEEEAKG
     GKRPKEGLLQ MKLPEPVKLQ MCLLLQYLCD CQVRHRIEAI VAFSDDFVAK LQDNQRFRYN
     EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSE CPCPEEIRDQ LLDFHEDLMT
     HCGIELDEDG SLDGNSDLTI RGRLLSLVEK VTYLKKKQAE KPVESDSKKS STLQQLISET
     MVRWAQESVI EDPELVRAMF VLLHRQYDGI GGLVRALPKT YTINGVSVED TINLLASLGQ
     IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
     EITFPKMVAN CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLASPAMR GSTPLDVAAA
     SVMDNNELAL ALREPDLEKV VRYLAGCGLQ SCQMLVSKGY PDIGWNPVEG ERYLDFLRFA
     VFCNGESVEE NANVVVRLLI RRPECFGPAL RGEGGNGLLA AMEEAIKIAE DPSRDGPSPN
     SGSSKTLDTE EEEDDTIHMG NAIMTFYSAL IDLLGRCAPE MHLIHAGKGE AIRIRSILRS
     LIPLGDLVGV ISIAFQMPTI AKDGNVVEPD MSAGFCPDHK AAMVLFLDRV YGIEVQDFLL
     HLLEVGFLPD LRAAASLDTA ALSATDMALA LNRYLCTAVL PLLTRCAPLF AGTEHHASLI
     DSLLHTVYRL SKGCSLTKAQ RDSIEVCLLS ICGQLRPSMM QHLLRRLVFD VPLLNEHAKM
     PLKLLTNHYE RCWKYYCLPG GWGNFGAASE EELHLSRKLF WGIFDALSQK KYEQELFKLA
     LPCLSAVAGA LPPDYMESNY VSMMEKQSSM DSEGNFNPQP VDTSNITIPE KLEYFINKYA
     EHSHDKWSMD KLANGWIYGE IYSDSSKVQP LMKPYKLLSE KEKEIYRWPI KESLKTMLAW
     GWRIERTREG DSMALYNRTR RISQTSQVSV DAAHGYSPRA IDMSNVTLSR DLHAMAEMMA
     ENYHNIWAKK KKMELESKGG GNHPLLVPYD TLTAKEKAKD REKAQDILKF LQINGYAVSR
     GFKDLELDTP SIEKRFAYSF LQQLIRYVDE AHQYILEFDG GSRGKGEHFP YEQEIKFFAK
     VVLPLIDQYF KNHRLYFLSA ASRPLCSGGH ASNKEKEMNI EKFSGQFIQH FVSSLGNDAT
     SIVNCLHILG QTLDARTVMK TGLESVKSAL RAFLDNAAED LEKTMENLKQ GQFTHTRNQP
     KGVTQIINYT TVALLPMLSS LFEHIGQHQF GEDLILEDVQ VSCYRILTSL YALGTSKSIY
     VERQRSALGE CLAAFAGAFP IAFLETHLDK HNIYSIYNTK SSRERAALSL PTNVEDVCPN
     IPSLEKLMEE IVELAESGIR YTQMPHVMEV ILPMLCSYMS RWWEHGPENN PERAEMCCTA
     LNSEHMNTLL GNILKIIYNN LGIDEGAWMK RLAVFSQPII NKVKPQLLKT HFLPLMEKLK
     KKAATVVSEE DHLKAEARGD MSEAELLILD EFTTLARDLY KYLYPFLIIL IYQINTYLCK
     NLQVLLVLTE ISFATSQNFK REEQNFVVQN EINNMSFLIT DTKSKMSKAA VSDQERKKMK
     RKGDRYSMQT SLIVAALKRL LPIGLNICAP GDQELIALAK NRFSLKDTED EVRDIIRSNI
     HLQGKLEDPA IRWQMALYKD LPNRTDDTSD PEKTVERVLD IANVLFHLEQ VEHPQRSKKA
     VWHKLLSKQR KRAVVACFRM APLYNLPRHR AVNLFLQGYE KSWIETEEHY FEDKLIEDLA
     KPGAEPPEED EGTKRVDPLH QLILLFSRTA LTEKCCHDEE DDDGEEEVKS FEEKEMEKQK
     LLYQQARLHD RGAAEMVLQT ISASKGETGP MVAATLKLGI AILNGGNSTV QQKMLDYLKE
     KKDVGFFQSL AGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSGEKVLQDD EFTCDLFRFL
     QLLCEGHNSD FQNYLRTQTG NNTTVNIIIS TVDYLLRVQE SISDFYWYYS GKDVIDEQGQ
     RNFSKAIQVA KQVFNTLTEY IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS
     QIELLKELMD LQKDMVVMLL SMLEGNVVNG TIGKQMVDML VESSNNVEMI LKFFDMFLKL
     KDLTSSDTFK EYDPDGKGVI SKRDFHKAME SHKHYTQSET EFLLSCAETD ENETLDYEEF
     VKRFHEPAKD IGFNVAVLLT NLSEHMPNDT RLQTFLELAE SVLNYFQPFL GRIEIMGSAK
     RIERVYFEIS ESSRTQWEKP QVKESKRQFI FDVVNEGGEK EKMELFVNFC EDTIFEMQLA
     AQISESDLNG RSANKEESEK ERPEEQGPRM AFFSILTVKS ALFALRYNIL TLMRMLSLKS
     LKKQMKKVKK MTVKDMVTAF FSSYWSIFMT LLHFVASVFR GFSRIICSLL LGGSLVEGAK
     KIKVAELLAN MPDPTQDEVR GDGEEGERKP LEAALPSEDL TDLKELTEES DLLSDIFGLD
     LKREGGQYKL IPHNPNAGLS DLMSNPVPMP EVQEKFQEQK AKEEEKEEKE ETKSEPEKAE
     GEDGEKEEKA KEDKGKQKLR QLHTHRYGEP EVPESAFWKK IIAYQQKLLN YFARNFYNMR
     MLALFVAFAI NFILLFYKVS TSSVVEGKEL PTRSSSENAK VTSLDSSSHR IIAVHYVLEE
     SSGYMEPTLR ILAILHTVIS FFCIIGYYCL KVPLVIFKRE KEVARKLEFD GLYITEQPSE
     DDIKGQWDRL VINTQSFPNN YWDKFVKRKV MDKYGEFYGR DRISELLGMD KAALDFSDAR
     EKKKPKKDSS LSAVLNSIDV KYQMWKLGVV FTDNSFLYLA WYMTMSVLGH YNNFFFAAHL
     LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDGDTPD
     MKCDDMLTCY MFHMYVGVRA GGGIGDEIED PAGDEYEIYR IIFDITFFFF VIVILLAIIQ
     GLIIDAFGEL RDQQEQVKED METKCFICGI GNDYFDTVPH GFETHTLQEH NLANYLFFLM
     YLINKDETEH TGQESYVWKM YQERCWEFFP AGDCFRKQYE DQLN
//
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