ID A0A2I3RZV1_PANTR Unreviewed; 970 AA.
AC A0A2I3RZV1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rho guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00017262};
DE AltName: Full=Guanine nucleotide exchange factor H1 {ECO:0000256|ARBA:ARBA00031760};
GN Name=ARHGEF2 {ECO:0000313|Ensembl:ENSPTRP00000070264.1,
GN ECO:0000313|VGNC:VGNC:6721};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000070264.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000070264.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000070264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; AC190157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3RZV1; -.
DR Ensembl; ENSPTRT00000086053.1; ENSPTRP00000070264.1; ENSPTRG00000001441.6.
DR VGNC; VGNC:6721; ARHGEF2.
DR GeneTree; ENSGT00940000158341; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000001441; Expressed in lymph node and 21 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd20877; C1_ARHGEF2; 1.
DR CDD; cd13393; PH_ARHGEF2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037806; ARHGEF2_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF20; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 37..84
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 226..423
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 463..562
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 109501 MW; 3298E7413A26C531 CRC64;
RQQSETLSQK KKEKKKSLDT REKEKMKEAK DARYTNGHLF TTISVSGMTM CYACNKSITA
KEALICPTCN VTIHNRCKDT LANCTKVKQK GGQRAGGEGS ECAVPSSTIR ERPSSAIYPS
DSFRQSLLGS RRGRSSLSLA KSVSTTNIAG HFNDESPLGL RRILSQSTDS LNMRNRTLSG
LGDERLVIYN ELMSDFEMDE KDFAADSWSL AVDSSFLQQH KKEVMKQQDV IYELIQTELR
HVRTLKIMTR LFRTGMLEEL HLEPGVVQGL FPCVDELSDI HTRFLSQLLE RRRQALCPGS
TRNFVIHRLG DLLISQFSGP SAEQMCKTYS EFCSRHTKAL KLYKELYARD KRFQQFIRKV
TRPAVLKRHG VQECIMLVTQ RITKYPLLIS RILQHSHGIE EERQDLTTAL GLVKELLSNV
DEGIYQLEKG ARLQEIYNRM DPRAQTPVPG KGPFGREELL RRKLIHDGCL LWKTATGRFK
DVLVLLMTDV LVFLQEKDQK YIFPTLDKPS VVSLQNLIVR DIANQEKGMF LISAAPPEMY
EVHTASRDDR STWIRVIQHS VRTCPSREDF PLIETEDEAY LRRIKMELQQ KDRALVELLR
EKVGLFAEMT HFQAEEDGGS GMALPTLPRG LFRSESLESP RGERLLQDAI REVEGLKDLL
VGPGVELLLT PREPALPLEP DSGGNTSPGV TANGEARTFN GSIELCRADS DSSQRVGPQE
EALQRLVNLY GLLHGLQAAV AQQDTLMEAR FPEGPERREK LCRANSRDGE AGRAGAAPVA
PEKQATELAL LQRQHALLQE ELRRCRRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEA
RRQLAALGQT EPLPSEAPWA RRPVDPRRRS LPAGDALYLS FNPPQPSRGT DRLDLPVTTR
SVHRHFEDRE RQELGSPEER LQDSSDPDTG SEEEGSSRLS PPHSPRDFTR MQDIPEETES
RDGEAVASES
//
