ID A0A2I3S346_PANTR Unreviewed; 357 AA.
AC A0A2I3S346;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Acetylserotonin O-methyltransferase {ECO:0000256|ARBA:ARBA00040730};
DE EC=2.1.1.4 {ECO:0000256|ARBA:ARBA00039116};
DE AltName: Full=Hydroxyindole O-methyltransferase {ECO:0000256|ARBA:ARBA00043054};
GN Name=ASMT {ECO:0000313|Ensembl:ENSPTRP00000071004.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000071004.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000071004.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000071004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a methyl group onto N-
CC acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
CC {ECO:0000256|ARBA:ARBA00037645}.
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000256|ARBA:ARBA00037926}.
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DR EMBL; AACZ04059747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3S346; -.
DR Ensembl; ENSPTRT00000078146.1; ENSPTRP00000071004.1; ENSPTRG00000045230.1.
DR GeneTree; ENSGT00940000161561; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000045230; Expressed in hindlimb stylopod muscle and 8 other cell types or tissues.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Melatonin biosynthesis {ECO:0000256|ARBA:ARBA00043260};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 12..111
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 129..339
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 267
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 357 AA; 39587 MW; 2B8812A620B521E5 CRC64;
MGSSEDHAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVGASAHGT
ELLLDICVSL KLLKVETRGG KGKDTGAFYI DTLSSYRNTE LSSDYLTTVS PTSQCSMLKY
MGRTSYRCWG HLADAVREGR NQYLETFGVP AEELFTAIYR SDGERLQFMQ ALQEVWSVNG
RSVLTAFDLS VFPLMCDLGG GAGALAKECM SLYPGCKITV FDIPEVVWTA KQHFSFQEEE
HIDFQEGDFF KDPLPEADLY ILARVLHDWA DGKCSHLLER IYHTCKPGGG ILVIESLLDE
DRRGPLLTQL YSLNMLVQTE GQERTPTQYH MLLSSAGFRD FQFKKTGAIY DAILARK
//
