GenomeNet

Database: UniProt
Entry: A0A2I3S461_PANTR
LinkDB: A0A2I3S461_PANTR
Original site: A0A2I3S461_PANTR 
ID   A0A2I3S461_PANTR        Unreviewed;      5001 AA.
AC   A0A2I3S461;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSPTRP00000071365};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSPTRP00000071365,
GN   ECO:0000313|VGNC:VGNC:7491};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000071365, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000071365, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000071365}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC193038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC193210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000080398; ENSPTRP00000071365; ENSPTRG00000010931.
DR   VGNC; VGNC:7491; RYR1.
DR   GeneTree; ENSGT00940000155288; -.
DR   Proteomes; UP000002277; Chromosome 19.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4311   4333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4524   4544       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4612   4635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4801   4823       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4882   4905       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    141       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      148    193       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      259    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      324    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      570    786       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1002   1197       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1345   1559       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1859   1914       {ECO:0000256|SAM:Coils}.
FT   COILED     2903   2923       {ECO:0000256|SAM:Coils}.
FT   COILED     3635   3655       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5001 AA;  561390 MW;  7E1E75AED5B7ADD6 CRC64;
     LGPSDDEVVL QCSATVLKEQ LKLCLAAEGF GNRLCFLEPT SNAQNVPPDL AICCFVLEQS
     LSVRALQEML ANTVEAGVES SQGGGHRTLL YGHAILLRHA HSRMYLSCLT TSRSMTDKLA
     FDVGLQEDAT GEACWWTMHP ASKQRSEGEK VRVGDDIILV SVSSERYLHL STASGELQVD
     ASFMQTLWNM NPICSRCEEG FVTGGHVLRL FHGHMDECLT ISPADSDDQR RLVYYEGGAV
     CTHARSLWRL EPLRISWSGS HLRWGQPLRV RHVTTGRYLA LTEDQGLVVV DASKAHTKAT
     SFCFRISKEK LDVAPKRDVE GMGPPEIKYG ESLCFVQHVA SGLWLTYAAP DPKALRLGVL
     KKKAMLHQEG HMDDALSLTR CQQEESQAAR MIHSTNGLYN QFIKSLDSFS GKPRGSGPPA
     GTALPIEGVI LSLQDLIIYF EPPSEDLQHE EKQSKLRSLR NRQSLFQEEG MLSMVLNCID
     RLNVYTTAAH FAEFAGEEAA ESWKEIVNLL YELLASLIRG NRSNCALFST NLDWLVSKLD
     RLEASSGILE VLYCVLIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV LCSLCVCNGV
     AVRSNQDLIT ENLLPGRELL LQTNLINYVT SIRPNIFVGR AEGTTQYSKW YFEVMVDEVT
     PFLTAQATHL RVGWALTEGY TPYPGAGEGW GGNGVGDDLY SYGFDGLHLW TGHVARPVTS
     PGQHLLAPED VISCCLDLSV PSISFRINGC PVQGVFESFN LDGLFFPVVS FSAGVRVRFL
     LGGRHGEFKF LPPPGYAPCH EAVLPRERLH LEPIKEYRRE GPRGPHLVGP SRCLSHTDFV
     PCPVDTVQIV LPPHLERIRE KLAENIHELW ALTRIEQGWT YGPVRDDNKR LHPCLVDFHS
     LPEPERNYNL QMSGETLKTL LALGCHVGMA DEKAEDNLKK TKLPKTYMMS NGYKPAPLDL
     SHVRLTPAQT TLVDRLAENG HNVWARDRVG QGWSYSAVQD IPARRNPRLV PYRLLDEATK
     RSNRDSLCQA VRTLLGYGYN IEPPDQEPSQ VENQSRCDRV RIFRAEKSYT VQSGRWYFEF
     EAVTTGEMRV GWARPELRPD VELGADELAY VFNGHRGQRW HLGSEPFGRP WQPGDVVGCM
     IDLTENTIIF TLNGEVLMSD SGSETAFREI EIGDGFLPVC SLGPGQVGHL NLGQDVSSLR
     FFAICGLQEG FEPFAINMQR PVTTWFSKGL PQFEPVPLEH PHYEVSRVDG TVDTPPCLRL
     THRTWGSQNS LVEMLFLRLS LPVQFHQHFR CTAGATPLAP PGLQPPAEDE ARAAEPDPDY
     ENLRRSAGGR GEAENGKEGT AKEGAPGGTP QAGGEAQPAR AENEKDATTE KNKKRGFLFK
     AKKVAMMTQP PATPTLPRLP HDVVPADNRD DPEIILNTTT YYYSVRVFAG QEPSCVWAGW
     VTPDYHQHDM SFDLSKVRVV TVTMGDEQGN VHSSLKCSNC YMVWGGDFVS PGQQGRISHT
     DLVIGCLVDL ATGLMTFTAN GKESNTFFQV EPNTKLFPAV FVLPTHQNVI QFELGKQKNI
     MPLSAAMFQS ERKNPAPQCP PRLEMQMLMP VSWSRMPNHF LQVETRRAGE RLGWAVQCQE
     PLTMMALHIP EENRCMDILE LSERLDLQRF HSHTLRLYRA VCALGNNRVA HALCSHVDQA
     QLLHALEDAH LPGPLRAGYY DLLISIHLES ACRSRRSMLS EYIVPLTPET RAITLFPPGR
     STENGHPRHG LPGVGVTTSL RPPHHFSPPC FVAALPAAGA AEAPARLSPA IPLEALRDKA
     LRMLGEAVRD GGQHARDPVG GSVEFQFVPV LKLVSTLLVM GIFGDEDVKQ ILKMIEPEVF
     TEEEEEEDEE EEEDEEEDEE EKEEDEEETA QEKEDEEKEE EEAAEGEKEE GLEEGLLQMK
     LPESVKLQMC HLLEYFCDQE LQHRVESLAA FAERYVDKLQ ANQRSRYGLL IKAFSMTAAE
     TARRTREFRS PPQEQINMLL QFKDGTDEED CPLPEEIRQD LLDFHQDLLA HCGIQLDGEE
     EEPEEETTLG SRLMSLLEKV RLVKKKEEKP EEERSAEESK PRSLQELVSH MVVRWAQEDF
     VQSPELVRAM FSLLHRQYDG LGELLRALPR AYTISPSSVE DTMSLLECLG QIRSLLIVQM
     GPQEENLMIQ SIGNIMNNKV FYQHPNLMRA LGMHETVMEV MVNVLGGGES KEIRFPKMVT
     SCCRFLCYFC RISRQNQRSM FDHLSYLLEN SGIGLGMQGS TPLDVAAASV IDNNELALAL
     QEQDLEKVVS YLAGCGLQSC PMLVAKGYPD IGWNPCGGER YLDFLRFAVF VNGESVEENA
     NVVVRLLIRK PECFGPALRG EGGSGLLAAI EEAIRISEDP ARDGPGIRRD RRREHFGEEP
     PEENRVHLGH AIMSFYAALI DLLGRCAPEM HLIQAGKGEA LRIRAILRSL VPLEDLVGII
     SLPLQIPTLG KDGALVQPKM SASFVPDHKA SMVLFLDRVY GIENQDFLLH VLDVGFLPDM
     RAAASLDTAT FSTTEMALAL NRYLCLAVLP LITKCAPLFA GTEHRAIMVD SMLHTVYRLS
     RGRSLTKAQR DVIEDCLMSL CRYIRPSMLQ HLLRRLVFDV PILNEFAKMP LKLLTNHYER
     CWKYYCLPTG WANFGVTSEE ELHLTRKLFW GIFDSLAHKK YDPELYRMAM PCLCAIAGAL
     PPDYVDASYS SKAEKKATVD AEGNFDPRPV ETLNVIIPEK LDSFINKFAE YTHEKWAFNK
     IQNNWSYGEN IDEELKTHPM LRPYKTFSEK DKEIYRWPIK ESLKAMIAWE WTIEKAREGE
     EEKTEKKKTR KISQSAQTYD PREGYNPQPP DLSAVTLSRE LQAMAEQLAE NYHNTWGRKK
     KQELEAKGGG THPLLVPYDT LTAKEKARDR EKAQELLKFL QMNGYAVTRG LKDMELDSSS
     IEKRFAFGFL QQLLRWMDIS QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILLPLINQYF
     TNHCLYFLST PAKVLGSGGH ASNKEKEMIT RWALMFPRCP SRTVMKSGPE IVKAGLRSFF
     ESASEDIEKM VENLRLGKVS QARTQVKGVG QNLTYTTVAL LPVLTTLFQH IAQHQFGDDV
     ILDDVQVSCY RTLCSIYSLG TTKNTYVEKL RPALGECLAR LAAAMPVAFL EPQLNEYNAC
     SVYTTKSPRE RAILGLPNSV EEMCPDIPVL ERLMADIGGL AESGARYTEM PHVIEITLPM
     LCSYLPRWWE RGPEAPPPAL PAGAPPPCTA VTSDHLNSLL GNILRIIVNN LGIDEASWMK
     RLAVFAQPIV SRARPELLQS HFIPTIGRLR KRAGKVVSEE EQLRLEAKAE AQEGELLVRD
     EFSVLCRDLY ALYPLLIRYV DNNRAQWLTE PNPSAEELFR MVGEIFIYWS KSHNFKREEQ
     NFVVQNEINN MSFLTADNKS KMAKVGSGGS DQERTKKKRR GDRYSVQTSL IVATLKKMLP
     IGLNMCAPTD QDLITLAKTR YALKDTDEEV REFLHNNLHL QGKVEGSPSL RWQMALYRGV
     PGREEDADDP EKIVRRVQEV SAVLYYLDQT EHPYKSKKAV WHKLLSKQRR RAVVACFRMT
     PLYNLPTHRA CNMFLESYKA VWILTEDHSF EDRMIDDLSK AGEQEEEEEE VEEKKPDPLH
     QLVLHFSRTA LTEKSKLDED YLYMAYADIM AKSCHLEEGG ENGEAEEEVE VSFEEKEMEK
     QRLLYQQARL HTRGAAEMVL QMISACKGET GAMVSSTLKL GISILNGGNA EVQQKMLDYL
     KDKKEVGFFQ SIQALMQTCS VLDLNAFERQ NKAEGLGMVN EDGTVINRQN GNSPREKVMA
     DDEFTQDLFR FLQLLCEGHN NDFQNYLRTQ TGNTTTINII ICTVDYLLRL QESISDFYWY
     YSGKDVIEEQ GKRNFSKAMS VAKQVFNSLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF
     AHMMMKLAQD SSQIELLKEL LDLQKDMVVM LLSLLEGNVV NGMIARQMVD MLVESSSNVE
     MILKFFDMFL KLKDIVGSEA FQDYVTDPRG LISKKDFQKA MDSQKQFSGP EIQFLLSCSE
     ADENEMINCE EFANRFQEPA RDIGFNVAVL LTNLSEHVPH DPRLHNFLEL AESILEYFRP
     YLGRIEIMGA SRRIERIYFE ISETNRAQWE MPQVKESKRQ FIFDVVNEGG EAEKMELFVS
     FCEDTIFEMQ IAAQISEPEG EPETDEDEGA GAAEAGAEGA EEGAAGLEGT AATAAAGATA
     RVVAAAGRAL RGLSYRSLRR RVRRLRRLTA REAATAVAAL LWAAVTRAGA AAAGAAAGAL
     GLLWGSLFGG GLVEGAKKVT VTELLAGMPD PTSDEVHGEQ PAGPGGDADG EGASEGAGDA
     AEGAGDEEEA VHEAGPGGAD GAVAVTDGGP FRPEGAGGLG DMGDTTPAEP PTPEGSPILK
     RKLGVREQAG FWGFGKMGDW REEESPAGAE NGEKEEVPEP PPEPPKKQAP PSPPPKKEEA
     GGEFWGELEV QRVKFLNYLS RNFYTLRFLA LFLAFAINFI LLFYKVSDSP PGEDDMEGSA
     AGDVSGAGSG GGSGWGLGAG EEAEGDEDEN MVYYFLEEST GYMEPALRCL SLLHTLVAFL
     CIIGYNCLKV PLVIFKREKE LARKLEFDGL YITEQPEDDD VKGQWDRLVL NTPSFPSNYW
     DKFVKRKVLD KHGDIYGRER IAELLGMDLA TLEITAHNER KPNPPPGLLT WLMSIDVKYQ
     IWKFGVIFTD NSFLYLGWYM VMSLLGHYNN FFFAAHLLDI AMGVKTLRTI LSSVTHNGKQ
     LVMTVGLLAV VVYLYTVVAF NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH MYVGVRAGGG
     IGDEIEDPAG DEYELYRVVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
     KCFICGIGSD YFDTTPHGFE THTLEEHNLA NYMFFLMYLI NKDETEHTGQ ESYVWKMYQE
     RCWDFFPAGD CFRKQYEDQL S
//
DBGET integrated database retrieval system