ID A0A2I3S5B2_PANTR Unreviewed; 142 AA.
AC A0A2I3S5B2; A0A2J8QCW9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
GN Name=FKBP2 {ECO:0000313|EMBL:JAA01883.1,
GN ECO:0000313|Ensembl:ENSPTRP00000072213.1,
GN ECO:0000313|VGNC:VGNC:11771};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000072213.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000072213.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA01883.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01883.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA40948.1}, Skin {ECO:0000313|EMBL:JAA23909.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA17602.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000072213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00277};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC175468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01009455; JAA01883.1; -; mRNA.
DR EMBL; GABC01009454; JAA01884.1; -; mRNA.
DR EMBL; GABC01009453; JAA01885.1; -; mRNA.
DR EMBL; GABF01004543; JAA17602.1; -; mRNA.
DR EMBL; GABF01004542; JAA17603.1; -; mRNA.
DR EMBL; GABD01009191; JAA23909.1; -; mRNA.
DR EMBL; GABD01009190; JAA23910.1; -; mRNA.
DR EMBL; GABE01003791; JAA40948.1; -; mRNA.
DR EMBL; GABE01003790; JAA40949.1; -; mRNA.
DR EMBL; GABE01003789; JAA40950.1; -; mRNA.
DR RefSeq; XP_001164246.2; XM_001164246.4.
DR RefSeq; XP_003313100.1; XM_003313052.3.
DR RefSeq; XP_003313101.1; XM_003313053.3.
DR RefSeq; XP_003313102.1; XM_003313054.4.
DR RefSeq; XP_003339245.1; XM_003339197.3.
DR RefSeq; XP_009421628.1; XM_009423353.2.
DR RefSeq; XP_016776641.1; XM_016921152.1.
DR STRING; 9598.ENSPTRP00000072213; -.
DR PaxDb; 9598-ENSPTRP00000006572; -.
DR Ensembl; ENSPTRT00000086720.1; ENSPTRP00000072213.1; ENSPTRG00000003826.5.
DR GeneID; 743135; -.
DR KEGG; ptr:743135; -.
DR CTD; 2286; -.
DR VGNC; VGNC:11771; FKBP2.
DR GeneTree; ENSGT00940000157074; -.
DR OMA; EQFDASW; -.
DR OrthoDB; 25281at2759; -.
DR TreeFam; TF105292; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003826; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central.
DR GO; GO:0061077; P:chaperone-mediated protein folding; IEA:InterPro.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR044609; FKBP2/11.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR45779:SF3; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2; 1.
DR PANTHER; PTHR45779; PEPTIDYLPROLYL ISOMERASE; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 2: Evidence at transcript level;
KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..142
FT /note="peptidylprolyl isomerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015081426"
FT DOMAIN 49..137
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
SQ SEQUENCE 142 AA; 15601 MW; 08E55BD69BA7A18A CRC64;
MRLSWVRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL
EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK
IPGGATLVFE VELLKIERRT EL
//
