ID A0A2I3S9H1_PANTR Unreviewed; 1427 AA.
AC A0A2I3S9H1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
GN Name=TONSL {ECO:0000313|Ensembl:ENSPTRP00000073471.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000073471.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000073471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR Ensembl; ENSPTRT00000080219.1; ENSPTRP00000073471.1; ENSPTRG00000047977.1.
DR GeneTree; ENSGT00940000160188; -.
DR InParanoid; A0A2I3S9H1; -.
DR OMA; FLESECC; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000047977; Expressed in cerebellar cortex and 17 other cell types or tissues.
DR GO; GO:0043596; C:nuclear replication fork; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0031297; P:replication fork processing; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT REPEAT 577..609
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 610..642
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 646..678
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..526
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..554
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1427 AA; 155747 MW; D2B2DF20F9EF9DB9 CRC64;
MPRAGRPYFP ECPAPAAAVE GRGLRVGGEG RGRGAAAQRG KSGSRGDPSM NLERELRQLS
KAKAKAQRAG QRREEAALCH QLGELLAGHG RYAEALEQHW QELQLRERAD DPLGCAVAHR
KIGERLAEME DYPAALQHQH QYLELAHSLR NHTELQRAWA TIGRTHLDIY DHCQSRDALL
QAQAAFEKSL AIVDEELEGT LAQGELNEMR TRLYLNLGLT FESLQQTALC NDYFRKSIFL
AEQNHLYEDL FRARYNLGTI HWRAGKHSQA MRCLEGAREC AHTMRKRFME SECCVAIAQV
LQDLGDFLAA KRALKKAYRL GSQKPVQRAA ICQNLQHVLA VVRLQQQLEE AEGRDPQGAM
VICEQLGDLF SKAGDFPRAA EAYQKQLRFA ELLDRPGAER AIIHVSLATT LGDMKDHHGA
VRHYEEELRL RSGNVLEEAK TWLNIALSRE EAGDAYELLA PCFQKALSCA QQAQRPQLQR
QVLQHLHTVQ LRLQPQEAPE TETRLRELSV AEDEDEEEEA EEAAATAESE ALEAGEVELS
ESEDDADGLT PQLEEDEELQ GHLGRRKGSK WNRRNDMGET LLHRACIEGQ LRRVQDLVRQ
GHPLNPRDYC GWTPLHEACN YGHLEIVRFL LDHGAAVDDP GGQGCEGITP LHDALNCGHF
EVAELLLERG ASVTLRTRKG LSPLETLQQW VKLYRRDLDL ETRQKARAVE MLLQAAASGQ
DPHSSQAFHT PSSLLFDPET SPPLSPCPEP PSNSTRLPEA SQAHVRVSPG QAAPAMARPR
RSRHGPASSS SSSEGEDSAG PARPSQKRPR CSATAQRVAA WTPGPASNRE AATASTSRAA
YQAAIRGVGS AQSRLGPGPP RGHSKALAPQ AALIPEEECL AGDWLELDMP LTRSRRPRPR
GTGDNRRPSS TSGSDSEESR PRARAKQVRL TCMQSCSAPV NAGPGSLASE PPGSPSTPRV
SEPSGDSSAA GQPLGPALPP PIRVRVQVQD HLFLIPVPHS SDTHSVAWLA EQAAQRYYQT
CGLLPRLTLR KEGALLAPQD LIPDVLQSND EVLAEVTSWD LPPLTDRYRR ACQSLGQGEH
QQVLQAVELQ GLGLSFSACS LALDQAQLTP LLRALKLHTA LRELRLAGNR LGDKCVAELV
AALGTMPSLA LLDLSSNHLG PEGLRQLAMG LPGQATLQSL EELDLSMNPL GDGCGQSLAS
LLRACPLLST LRLQACGFGP SFFPSHQTAL GSAFQDAEHL KTLSLSYNAL GAPALARTLQ
SLPAGTLLHL ELSSVAAGKG DADLMEPVFR YLAKEGCALA HLTLSANHLG DKAVRDLCRC
LSLCPSLISL DLSANPEISC ASLEELLSTL QKRPQGLSFL GLSGCAVQGP LGLGLWDKIA
AQLRELQLCS RRLCAEDRDA LRQLQPSRPG AGECTLDHGS KLFFRRL
//
