ID   A0A2I3S9K0_PANTR        Unreviewed;       836 AA.
AC   A0A2I3S9K0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSPTRP00000073664.1,
GN   ECO:0000313|VGNC:VGNC:2742};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000073664.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000073664.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000073664.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   EMBL; AACZ04058557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04058558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3S9K0; -.
DR   Ensembl; ENSPTRT00000084549.1; ENSPTRP00000073664.1; ENSPTRG00000012687.6.
DR   VGNC; VGNC:2742; OSBPL6.
DR   GeneTree; ENSGT00940000156791; -.
DR   Proteomes; UP000002277; Chromosome 2B.
DR   Bgee; ENSPTRG00000012687; Expressed in skeletal muscle tissue and 17 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          1..89
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   836 AA;  95697 MW;  D00E6BC74452F3FD CRC64;
     MLKKRKWPLK GWHKRFFVLD NGMLKYSKAP LDIQKGKVHG SIDVGLSVMS IKKKARRIDL
     DTEEHIYHLK VKSQDWFDAW VCKLRHHRLY RQNEIVRSPR DASFHIFPST STAESSPAAN
     VSVMDGKMQP NSFPWQSPLP CSNSLPATCT SGQSKVAAWL QDSEEMDRCA EDLAHCQSNL
     VELSKLLQNL EILQRTQSAP NFTDMQANCV DISKKDKRVT RRWRTKSVSK DTKIQLGLFC
     VGECETMHCC SLIICIFPFQ VPFSATMSPV RLHSSNPNLC ADIEFQTPPS HLTDPLESST
     DYTKLQEEFC LIAQKVHSLL KSAFNSIAIE KEKLKQMVSE QDHSKGHSTQ MARLRQSLSQ
     AGEQIHVSLP LSQQVANESR LSMSESVSEF FDAQEVLLSA SSSENEASDD ESYISDVSDN
     ISEDNTSVAD NISRQILNGE LTGGAFRNGR RACLPAPCPD TSNINLWNIL RNNIGKDLSK
     VSMPVELNEP LNTLQHLCEE MEYSELLDKA SETDDPYERM VLVAAFAVSG YCSTYFRAGS
     KPFNPVLGET YECIREDKGF RFFSEQVSHH PPISACHCES KNFVFWQDIR WKNKFWGKSM
     EILPVGTLNV MLPKYGDYYV WNKVTTCIHN ILSGRRWIEH YGEVTIRNTK SSVCICKLTF
     VKVNYWNSNM NEVQGVVIDQ EGKAVYRLFG KWHEGLYCGV APSAKCIWRP GSMPTNYELY
     YGFTRFAIEL NELDPVLKDL LPPTDARFRP DQRFLEEGNL EAAASEKQRV EELQRSRRRY
     MEENNLEHIP KFFKKVIDAN QREAWVSNDT YWELRKDPGF SKVDNWECRA SQHITF
//