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Database: UniProt
Entry: A0A2I3S9P0_PANTR
LinkDB: A0A2I3S9P0_PANTR
Original site: A0A2I3S9P0_PANTR 
ID   A0A2I3S9P0_PANTR        Unreviewed;       445 AA.
AC   A0A2I3S9P0; A0A2J8LNR4;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   16-OCT-2019, entry version 15.
DE   SubName: Full=KCNJ4 isoform 1 {ECO:0000313|EMBL:PNI48908.1};
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 4 {ECO:0000313|Ensembl:ENSPTRP00000073546};
GN   Name=KCNJ4 {ECO:0000313|Ensembl:ENSPTRP00000073546,
GN   ECO:0000313|VGNC:VGNC:12883};
GN   ORFNames=CK820_G0027637 {ECO:0000313|EMBL:PNI48908.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000073546, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000073546, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164055; DOI=10.1038/nature02564;
RA   Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A.,
RA   Kuroki Y., Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M.,
RA   Taenzer S., Galgoczy P., Platzer M., Scharfe M., Nordsiek G.,
RA   Bloecker H., Hellmann I., Khaitovich P., Paabo S., Reinhardt R.,
RA   Zheng H.-J., Zhang X.-L., Zhu G.-F., Wang B.-F., Fu G., Ren S.-X.,
RA   Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E., Choi S.-H., Wu K.-M.,
RA   Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G., Oota S., Kitano T.,
RA   Kohara Y., Saitou N., Park H.-S., Wang S.-Y., Yaspo M.-L., Sakaki Y.;
RT   "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL   Nature 429:382-388(2004).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000073546, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [3] {ECO:0000313|EMBL:PNI48908.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI48908.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:PNI48908.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSPTRP00000073546}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AACZ04068047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NBAG03000283; PNI48908.1; -; Genomic_DNA.
DR   RefSeq; XP_016794662.1; XM_016939173.1.
DR   RefSeq; XP_525593.2; XM_525593.5.
DR   SMR; A0A2I3S9P0; -.
DR   Ensembl; ENSPTRT00000094285; ENSPTRP00000073546; ENSPTRG00000050908.
DR   GeneID; 470209; -.
DR   KEGG; ptr:470209; -.
DR   CTD; 3761; -.
DR   VGNC; VGNC:12883; KCNJ4.
DR   GeneTree; ENSGT00960000186595; -.
DR   KO; K04998; -.
DR   OMA; GHNRNGQ; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000002277; Chromosome 22.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003273; K_chnl_inward-rec_Kir2.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF53; PTHR11767:SF53; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01326; KIR23CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     57     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    173       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    178       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      185    357       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   COILED      370    393       {ECO:0000256|SAM:Coils}.
FT   SITE        164    164       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   445 AA;  49500 MW;  893F03365273E8BE CRC64;
     MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM
     IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG
     FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK
     RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR
     DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT
     TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV
     LPAPPPPPSA FCYENELALM SQEEEEMEEE AAAAAAVAAG LGLEAGSKEE AGIIRMLEFG
     SHLDLERMQA SLPLDNISYR RESAI
//
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